Home > 5-HT Receptor & 5-HT Receptor & > Ondansetron HCl

Ondansetron HCl

盐酸恩丹西酮,盐酸昂丹司琼,盐酸昂旦司琼,GR 38032F,GR-38032F,GR38032F

Ondansetron盐酸盐是5-HT3受体拮抗剂，可作为化疗后止吐剂。

目录号
EY1381
EY1381
纯度
99.53%
99.53%
规格
5 mg
10 mg
原价
680
980
售价
680
980
库存
现货
现货
订购
订购
订购
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  • 生物活性

    Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Pinelli A, et al. Eur J Pharmacol,?997, 340(2-3), 111-119.

    分子式
    C18H19N3O.HCl    		 分子量
    329.82    		 CAS号
    99614-01-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    60 mg/mL    		 Water
    20 mg/mL    		 Ethanol
    10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01759420 Ondansetron Drug: Ondansetron C.R.Darnall Army Medical Center|Madigan Army Medical Center 2012-12-01 2014-06-24
    NCT00934180 Healthy Drug: Ondansetron|Drug: Zofran Teva Pharmaceuticals USA Phase 1 2002-12-01 2009-07-08
    NCT00934921 Healthy Drug: Ondansetron|Drug: Zofran Teva Pharmaceuticals USA Phase 1 2003-02-01 2009-07-08
    NCT00946387 Nausea|Vomiting Drug: Ondansetron HCl 24 mg Tablets (Sandoz, Inc.)|Drug: Zofran (Ondansetron HCl) 24 mg Tablets (GlaxoSmithKline) Sandoz Phase 1 2004-09-01 2009-07-24
    NCT00947128 Nausea|Vomiting Drug: Ondansetron HCl 24 mg Tablets (Sandoz, Inc.)|Drug: Zofran (Ondansetron HCl) 24 mg Tablets (GlaxoSmithKline) Sandoz Phase 1 2004-09-01 2009-07-24
    NCT02901054 Pain Drug: Ondansetron Washington University School of Medicine 2016-08-01 2016-10-13
    NCT02473887 Gastroenteritis Drug: Ondansetron with1:1 ORA - sweet. Hamad Medical Corporation Phase 1 2014-09-01 2015-06-14
    NCT00890149 Alcohol Abuse|Alcoholism Drug: Ondansetron + BASICS Plus|Drug: Placebo + BASICS Plus Bankole A. Johnson|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|University of Maryland Phase 2 2015-09-01 2015-12-03
    NCT03052361 Gastroenteritis Drug: Ondansetron|Drug: Placebos St. Justine's Hospital Phase 2|Phase 3 2017-06-01 2017-02-13
    NCT01896440 Malignant Childhood Neoplasm Drug: Ondansetron University of Oklahoma Phase 4 2013-10-01 2013-10-04
    NCT01801475 Postoperative Nausea Drug: Ondansetron Stanford University Phase 1|Phase 2 2013-01-01 2015-05-28
    NCT00796497 Obsessive Compulsive Disorder Drug: ondansetron Institute of Neuroscience, Florence, Italy Phase 4 2008-03-01 2011-02-23
    NCT02985840 Nausea|Abdominal Pain Drug: Ondansetron|Drug: Dexamethasone OhioHealth Phase 4 2013-10-01 2017-01-25
    NCT00678457 Alcohol Dependence Drug: Ondansetron|Drug: Olanzapine|Drug: Placebo University of Virginia Phase 2 2007-01-01 2009-01-29
    NCT01275248 Obsessive-compulsive Disorder Drug: Ondansetron|Drug: Placebo Transcept Pharmaceuticals Phase 2 2011-01-01 2013-01-16
    NCT00387556 Conscious Sedation Drug: Ondansetron University of Colorado, Denver 2002-12-01 2013-05-09
    NCT02296333 Postoperative Pain Drug: ondansetron|Drug: isotonic Mustafa Kemal University Phase 4 2014-05-01 2015-03-12
    NCT01815125 Traumatic Brain Injury|Brain Concussion Drug: Ondansetron|Drug: PLacebo St. Justine's Hospital Phase 1 2013-03-01 2015-09-28
    NCT02460341 Brain Function|Healthy Adults Drug: ondansetron|Drug: placebo Icahn School of Medicine at Mount Sinai Phase 4 2015-08-01 2016-09-12

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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