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Naratriptan

那拉曲坦,纳拉曲坦,那拉曲普坦,诺拉替坦

Naratriptan盐酸盐是5-HT1受体激动剂，可作用于偏头疼。

目录号
EY1380
EY1380
EY1380
纯度
99.66%
99.66%
99.66%
规格
5 mg
10 mg
50 mg
原价
420
680
2100
售价
420
680
2100
库存
现货
现货
现货
订购
订购
订购
订购
订购
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  • 生物活性

    Naratriptan is a triptan agent that is used for the treatment of migraine headaches.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Demet Akin, et al. Agonist-directed trafficking explaining the difference between response pattern of naratriptan and sumatriptan in rabbit common carotid artery. Br J Pharmacol. 2002 May; 136(2): 171–176. doi: 10.1038/sj.bjp.0704710
    [2] Peter J Goadsby,et al. Inhibition of trigeminal neurones after intravenous administration of naratriptan through an action at 5-hydroxy-tryptamine (5-HT1B/1D) receptors. Br J Pharmacol. 1997 Nov; 122(5): 918–922. doi: 10.1038/sj.bjp.0701456.

    分子式
    C17H26ClN3O2S    		 分子量
    371.93    		 CAS号
    143388-64-1    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    60 mg/mL    		 Water
    15 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00487578 Post Traumatic Headache Drug: naratriptan HCl Cady, Roger, M.D.|GlaxoSmithKline|Clinvest Phase 4 2006-10-01 2013-02-04
    NCT01726920 Migraine|Headache Drug: naratriptan + naproxen|Drug: naratriptan|Drug: naproxen Ache Laboratorios Farmaceuticos S.A. Phase 3 2014-07-01 2016-03-15
    NCT01376193 Migraine Disorders Drug: Naratriptan GlaxoSmithKline 2009-04-01 2013-05-16
    NCT01390324 Migraine|Headache Drug: Fixed-dose combination of naratriptan+naproxen|Drug: Naratriptan|Drug: Naproxen Ache Laboratorios Farmaceuticos S.A. Phase 3 2011-12-01 2016-10-18
    NCT01161654 Migraine Drug: naratriptan hydrochoride Roxane Laboratories 2007-08-01 2010-07-12
    NCT01161667 Migraine Drug: naratriptan hydrochloride Roxane Laboratories 2007-09-01 2010-07-12
    NCT01059604 Migraine Disorders Drug: Sumatriptan|Drug: Naratriptan|Drug: Sumatriptan-naproxen combination GlaxoSmithKline 2001-12-01 2014-10-30
    NCT01332383 Migraine Disorders Drug: Naratriptan GlaxoSmithKline 2009-05-01 2015-08-10
    NCT00282165 Psychotic Disorders|Antisocial Personality Disorder|Impulse Regulation Disorder|Intermittent Explosive Disorder Drug: naratriptan|Drug: placebo UMC Utrecht|FPC De Kijvelanden, Poortugaal Phase 4 2006-11-01 2015-01-23
    NCT03066544 Migraine Drug: Bupivacaine|Drug: Naratriptan Pill|Drug: Dexamethasone|Drug: Ketorolac Hartford HealthCare 2016-11-30 2017-02-27
    NCT01435941 Migraine Disorders Drug: Non-steroidal anti-inflammatory drug (NSAID)|Drug: Triptan GlaxoSmithKline 2009-09-01 2011-09-21
    NCT01381497 Migraine Disorders Drug: Combination therapy of sumatriptan and naproxen sodium (SumaRT/Nap)|Drug: Triptan monotherapy GlaxoSmithKline 2010-03-01 2012-08-23
    NCT01381523 Migraine Disorders Drug: Combination therapy with sumatriptan and naproxen sodium (SumaRT/Nap)|Drug: Single-entity oral triptans GlaxoSmithKline 2010-11-01 2013-02-21
    NCT01086358 Workplace Migraine Treatment Drug: Usual prescribed triptan|Drug: Treximet for migraine treatment The Cleveland Clinic|Pernix Theraputics LLC Phase 4 2009-09-01 2016-08-10
    NCT01332500 Migraine Disorders Drug: Sumatriptan/Naproxen combination|Drug: other oral triptans GlaxoSmithKline 2009-07-01 2011-04-19

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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