Home > Calcium Channel & > Felodipine

Felodipine

非洛地平,CGH-869,CGH 869,CGH869

Felodipine是长效的钙离子通道阻断剂。

目录号
EY1376
EY1376
EY1376
纯度
99.37%
99.37%
99.37%
规格
5 mg
10 mg
50 mg
原价
398
640
2100
售价
398
640
2100
库存
现货
现货
现货
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  • 生物活性

    Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    1 g/kg/day口服处理

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Johnson JD, et al. J Pharmacol Exp Ther, 1983, 226(2), 330-334.

    分子式
    C18H19Cl2NO4    		 分子量
    384.25    		 CAS号
    72509-76-3    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    >25 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    >25 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02232269 Food-Drug Interactions Other: Black Coffee|Other: Grapefruit Juice|Other: Water|Drug: Felodipine Lawson Health Research Institute Phase 1 2012-02-01 2014-09-02
    NCT01136863 Hypertension Drug: Felodipine|Drug: Placebo Chinese Academy of Medical Sciences|Shanxi Kangbao Pharmaceutical company|Beijing Hypertension League Insititute 1998-04-01 2010-06-23
    NCT02311530 Healthy Drug: Felodipine|Drug: Felodipine (Plendil) Ranbaxy Laboratories Limited|Ranbaxy Inc. 2008-10-01 2014-12-05
    NCT02327247 Healthy Drug: Felodipine|Drug: PLENDIL庐 Ranbaxy Laboratories Limited|Ranbaxy Inc. 2008-09-01 2014-12-23
    NCT02336607 Hypertension Drug: Felodipine tablet (Plendil) alone|Drug: Felodipine tablet (Plendil)+Hydrochlorothiazide|Drug: Felodipine tablet (Plendil)+Metoprolol tablet (Betaloc ZOK)|Drug: Felodipine tablets (Plendil)+Lisinopril (Zestril) AstraZeneca 2005-12-01 2015-03-13
    NCT00507845 Hypertension Drug: Ramipril-Felodipine Sanofi Phase 4 2007-06-01 2009-04-16
    NCT01520285 Hypertension Drug: Zanidip|Drug: Felodipine sustained-release tablet Lee's Pharmaceutical Limited Phase 4 2011-12-01 2014-10-14
    NCT00905333 Healthy Drug: Candesartan (test)|Drug: Felodipine (test)|Drug: Candesartan Cilexetil|Drug: Felodipine AstraZeneca|Scentryphar Clinical Research|Cori Analyticals|Clnica So Lucas, Hospital Srio Libans de Itatiba S/C|LabClin Laboratrio Clnico|Laborat贸rio de Patologia Clnica Dr. Franceschi Ltda.|Faculdade de Cincias Farmacuticas de Ribeiro Preto - Centro de Bioequivalncia Phase 1 2008-10-01 2010-12-06
    NCT01630902 Healthy Drug: Torrent's Felodipine Extended-Release Tablets Torrent Pharmaceuticals Limited Phase 1 2012-06-27
    NCT01630655 Healthy Drug: Torrent's Felodipine Extended-Release Tablets Torrent Pharmaceuticals Limited Phase 1 2012-06-27
    NCT01238705 Hypertension|Sexual Dysfunction Drug: Felodipine add Irbesartan|Drug: Felodipine add Metoprolol LanZhou University Phase 4 2008-04-01 2010-11-10
    NCT00841880 Hypertension Drug: Ramipril + Felodipine|Drug: Ramipril|Drug: Ramipril Sanofi Phase 4 2009-01-01 2010-08-26
    NCT02744872 Disorder Related to Lung Transplantation Drug: Felodipine|Drug: Placebo Rigshospitalet, Denmark Phase 4 2013-09-01 2016-10-05
    NCT00367939 Hypertension Drug: valsartan + amlodipine Novartis Phase 3 2005-12-01 2011-11-07
    NCT00861016 Hypertension Drug: metoprolol succinate prolonged-release tablet and felodipine AstraZeneca Phase 4 2005-10-01 2009-03-12
    NCT00392262 Hypertension Drug: valsartan + amlodipine Novartis Phase 3 2006-08-01 2016-11-16
    NCT00742066 Hypertension|Insulin Resistance|Microcirculation Drug: Irbesartan|Drug: Felodipine|Drug: Placebo Maastricht University Medical Center 2008-03-01 2011-03-16
    NCT00348686 Hypertension|Left Ventricular Hypertrophy Drug: Candesartan|Drug: Candesartan|Drug: Felodipine|Drug: Felodipine AstraZeneca Phase 4 2006-06-01 2012-03-05
    NCT00679653 Obesity|Hypertension Drug: sibutramine|Drug: sibutramine|Drug: verapamil/trandolapril|Drug: metoprolol/HCT|Drug: felodipine/ramipril Abbott Phase 3 2002-02-01 2008-05-16
    NCT00684489 Hypertension Drug: clinical hypertension specialist-no specific med. Any anti-hypertension meds.|Drug: renin guided therapeutics-no specific med. Any anti-hypertensive med. Medical University of South Carolina|New York Presbyterian Hospital 2003-09-01 2008-05-22
    NCT00582114 Hemodialysis|Hypertension|Left Ventricular Hypertrophy Drug: Lisinopril|Drug: Atenolol Indiana University|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 3 2005-08-01 2015-12-14
    NCT02988102 Biomarkers Other: Following S100B and NSE in head trauma University Clinical Centre of Kosova 2016-12-01 2016-12-08
    NCT00000620 Atherosclerosis|Cardiovascular Diseases|Hypercholesterolemia|Hypertension|Diabetes Mellitus, Type 2|Diabetes Mellitus|Coronary Disease Drug: Anti-hyperglycemic Agents|Drug: Anti-hypertensive Agents|Drug: Blinded fenofibrate or placebo plus simvastatin National Heart, Lung, and Blood Institute (NHLBI)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institute on Aging (NIA)|National Eye Institute (NEI)|Centers for Disease Control and Prevention Phase 3 1999-09-01 2016-11-21

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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