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Ellagic acid

鞣花酸,Elagostasine,Gallogen

Ellagic Acid是可通透细胞的酪蛋白激酶2(CK2)抑制剂,Ki为20 nM,是抗氧化剂和抗突变剂。

目录号
EY1366
EY1366
EY1366
纯度
99.67%
99.67%
99.67%
规格
500 mg
1 g
5 g
原价
470
690
2000
售价
470
690
2000
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Ellagic acid has antiproliferative and antioxidant property.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] H Hayatsu et. Al. Dietary inhibitors of mutagenesis and carcinogenesis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 202(2), 429-446 (1988).
    [2] A Castonguay et. Al. Biodistribution of, antimutagenic efficacies in Salmonella typhimurium of, and inhibition of P450 activities by ellagic acid and one analogue. Chemical Research in Toxicology, 11(11), 1258-1264 (1998).
    [3] Cassandra L Quave et. Al. PLoS ONE, 10(8), e0136486 (2015).
    [4] Shosuke Ito and Kazumasa Wakamatsu. Journal of Dermatological Science, 80(1), 18-24 (2015).

    分子式
    C14H6O8
    分子量
    302.19
    CAS号
    476-66-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    10 mM
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02263378 HPV Infection Drug: ellagic acid + annona muricata University of Messina 2014-09-01 2016-05-23
    NCT02056496 Healthy Dietary Supplement: Pomegranate extract|Dietary Supplement: Pomegranate extract National Research Council, Spain|Universidad Catlica San Antonio de Murcia Phase 1 2014-01-01 2015-04-13
    NCT01916239 Colorectal Cancer Dietary Supplement: Standard pomegranate extract formulation|Dietary Supplement: Pomegranate extract formulation-1|Dietary Supplement: Pomegranate extract formulation-2 National Research Council, Spain|Hospital Universitario Reina Sofia Phase 1|Phase 2 2012-06-01 2015-04-13
    NCT01249469 Solar Lentigines Other: skin whitening cosmetic product National Taiwan University Hospital|L'Oreal 2010-06-01 2010-11-25
    NCT01705093 Childhood Obesity|Cardiovascular Disease Dietary Supplement: flavonoid-rich freeze-dried strawberry powder|Dietary Supplement: macronutrient-matched control powder University of California, Davis Phase 2 2013-02-01 2012-10-10
    NCT02370641 Urolith Dietary Supplement: PomX University of California, Los Angeles 2012-10-01 2017-02-27
    NCT01961869 Healthy Volunteers Other: Fast release BRB confection|Other: Intermed release BRBconfect|Other: Prolong release BRB confect Ohio State University Comprehensive Cancer Center Phase 1 2013-07-01 2017-03-14
    NCT02935777 Mental Processes Dietary Supplement: Pomegranate Extract|Dietary Supplement: Placebo capsule Angela Stockton|Northumbria University|Queen Margaret University Phase 1 2014-04-01 2016-10-13
    NCT00455416 Follicular Lymphoma Drug: Omega 3 fatty acids (EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid))|Drug: Selenium (L-Selenomethionine),|Drug: Garlic extract (Allicin)|Drug: Pomegranate juice (ellagic acid)|Drug: Grape juice (resveratrol, quercetin)|Drug: Green Tea (Epigallocathechin gallate) Oslo University Hospital|University of Oslo Phase 2 2007-04-01 2008-05-20
    NCT02333461 Overweight|Obesity Dietary Supplement: Placebo|Dietary Supplement: Apple|Dietary Supplement: Grape|Dietary Supplement: Raspberry|Dietary Supplement: Apricot/Nectarine Access Business Group|Radiant Research 2012-05-01 2015-01-06
    NCT00788866 Intrauterine Growth Restriction Dietary Supplement: Pomegranate Juice|Dietary Supplement: Placebo Washington University School of Medicine|POM Wonderful LLC|University of California, Los Angeles 2008-12-01 2014-10-16
    NCT02005939 Cardiovascular Risk Factors Dietary Supplement: Pomegranate extract Queen Margaret University|PomeGreat 2012-04-01 2013-12-04

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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