Ellagic Acid是可通透细胞的酪蛋白激酶2(CK2)抑制剂,Ki为20 nM,是抗氧化剂和抗突变剂。
Ellagic acid has antiproliferative and antioxidant property.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] H Hayatsu et. Al. Dietary inhibitors of mutagenesis and carcinogenesis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 202(2), 429-446 (1988).
[2] A Castonguay et. Al. Biodistribution of, antimutagenic efficacies in Salmonella typhimurium of, and inhibition of P450 activities by ellagic acid and one analogue. Chemical Research in Toxicology, 11(11), 1258-1264 (1998).
[3] Cassandra L Quave et. Al. PLoS ONE, 10(8), e0136486 (2015).
[4] Shosuke Ito and Kazumasa Wakamatsu. Journal of Dermatological Science, 80(1), 18-24 (2015).
分子式 C14H6O8 |
分子量 302.19 |
CAS号 476-66-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 10 mM |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02263378 | HPV Infection | Drug: ellagic acid + annona muricata | University of Messina | 2014-09-01 | 2016-05-23 | |
NCT02056496 | Healthy | Dietary Supplement: Pomegranate extract|Dietary Supplement: Pomegranate extract | National Research Council, Spain|Universidad Catlica San Antonio de Murcia | Phase 1 | 2014-01-01 | 2015-04-13 |
NCT01916239 | Colorectal Cancer | Dietary Supplement: Standard pomegranate extract formulation|Dietary Supplement: Pomegranate extract formulation-1|Dietary Supplement: Pomegranate extract formulation-2 | National Research Council, Spain|Hospital Universitario Reina Sofia | Phase 1|Phase 2 | 2012-06-01 | 2015-04-13 |
NCT01249469 | Solar Lentigines | Other: skin whitening cosmetic product | National Taiwan University Hospital|L'Oreal | 2010-06-01 | 2010-11-25 | |
NCT01705093 | Childhood Obesity|Cardiovascular Disease | Dietary Supplement: flavonoid-rich freeze-dried strawberry powder|Dietary Supplement: macronutrient-matched control powder | University of California, Davis | Phase 2 | 2013-02-01 | 2012-10-10 |
NCT02370641 | Urolith | Dietary Supplement: PomX | University of California, Los Angeles | 2012-10-01 | 2017-02-27 | |
NCT01961869 | Healthy Volunteers | Other: Fast release BRB confection|Other: Intermed release BRBconfect|Other: Prolong release BRB confect | Ohio State University Comprehensive Cancer Center | Phase 1 | 2013-07-01 | 2017-03-14 |
NCT02935777 | Mental Processes | Dietary Supplement: Pomegranate Extract|Dietary Supplement: Placebo capsule | Angela Stockton|Northumbria University|Queen Margaret University | Phase 1 | 2014-04-01 | 2016-10-13 |
NCT00455416 | Follicular Lymphoma | Drug: Omega 3 fatty acids (EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid))|Drug: Selenium (L-Selenomethionine),|Drug: Garlic extract (Allicin)|Drug: Pomegranate juice (ellagic acid)|Drug: Grape juice (resveratrol, quercetin)|Drug: Green Tea (Epigallocathechin gallate) | Oslo University Hospital|University of Oslo | Phase 2 | 2007-04-01 | 2008-05-20 |
NCT02333461 | Overweight|Obesity | Dietary Supplement: Placebo|Dietary Supplement: Apple|Dietary Supplement: Grape|Dietary Supplement: Raspberry|Dietary Supplement: Apricot/Nectarine | Access Business Group|Radiant Research | 2012-05-01 | 2015-01-06 | |
NCT00788866 | Intrauterine Growth Restriction | Dietary Supplement: Pomegranate Juice|Dietary Supplement: Placebo | Washington University School of Medicine|POM Wonderful LLC|University of California, Los Angeles | 2008-12-01 | 2014-10-16 | |
NCT02005939 | Cardiovascular Risk Factors | Dietary Supplement: Pomegranate extract | Queen Margaret University|PomeGreat | 2012-04-01 | 2013-12-04 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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