Artesunate 是一种抗疟类药,作用于小细胞肺癌细胞系H69,IC50为< 5 μM。
Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Efferth, T., et al. 2003. Mol. Pharmacol. 64: 382-394. PMID: 12869643
[2] Efferth, T et al. 2001. Int. J. Oncol. 18: 767-773. PMID: 11251172
[3] Price, R.N. 2000. Expert Opin Investig Drugs. 9: 1815-1827. PMID: 11060779
分子式 C19H28O8 |
分子量 384.42 |
CAS号 88495-63-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO >50 mg/mL |
Water <1 mg/mL |
Ethanol >50 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02084602 | Malaria, Falciparum | Drug: Artesunate|Drug: Mefloquine | Instituto Nacional de Salud. Peru|Naval Medical Research Unit No 6 | Phase 4 | 2014-06-01 | 2014-06-04 |
NCT00298610 | Malaria | Drug: Artesunate and Malarone | U.S. Army Medical Research and Materiel Command|Military Infectious Diseases Research Program (MIDRP) | Phase 2 | 2006-03-01 | 2017-02-01 |
NCT01122134 | Severe Malaria | Drug: intravenous artesunate | Makerere University | 2010-05-01 | 2010-05-10 | |
NCT01805232 | Malaria | Drug: artesunate|Drug: Quinine | University of Khartoum|University of Kassala, Sudan|Kassala|Sudan | Phase 4 | 2013-03-01 | 2013-03-04 |
NCT02304289 | Hepatocellular Carcinoma | Drug: Artesunate | University Hospital, Ghent|University Ghent|Anticancer Fund, Belgium | Phase 1 | 2014-11-01 | 2017-01-03 |
NCT02353026 | Solid Tumors | Drug: Intravenous Artesunate | Georgetown University|United States Department of Defense | Phase 1 | 2015-01-01 | 2016-11-17 |
NCT02297477 | Malaria | Drug: atovaquone-proguanil|Drug: artesunate-atovaquone-proguanil | Armed Forces Research Institute of Medical Sciences, Thailand|National Centre for Parasitology, Entomology and Malaria Control, Cambodia|Naval Medical Research Center, Asia (NMRC-A) | Phase 4 | 2014-12-01 | 2016-01-10 |
NCT01144702 | Falciparum Malaria | Drug: artesunate & mefloquine combination | Oswaldo Cruz Foundation|Pan American Health Organization|Ministry of Health, Brazil|University of Sao Paulo | Phase 2|Phase 3 | 2010-11-01 | 2015-05-15 |
NCT01552330 | Healthy | Drug: Primaquine and Pyronaridine-artesunate|Drug: Primaquine and Pyronaridine-Artesunate | University of Oxford | Phase 1 | 2012-05-01 | 2013-08-27 |
NCT01023399 | Malaria | Drug: Artesunate + Amodiaquine | Sanofi|Medicines for Malaria Venture | Phase 4 | 2009-11-01 | 2015-02-20 |
NCT00538382 | Malaria | Drug: Artesunate | NICHD Global Network for Women's and Children's Health|Global Network for Women's and Children's Health Research|Bill and Melinda Gates Foundation|John E. Fogarty International Center (FIC)|National Center for Complementary and Integrative Health (NCCIH)|National Institute of Dental and Craniofacial Research (NIDCR)|National Cancer Institute (NCI)|RTI International|University of North Carolina|Kinshasa School of Public Health | Phase 1 | 2007-05-01 | 2014-07-29 |
NCT00894374 | Falciparum Malaria | Drug: Artesunate (Test)|Drug: Artesunate (Comparator) | Pfizer | Phase 1 | 2009-06-01 | 2010-06-24 |
NCT00331136 | Uncomplicated Plasmodium Falciparum Malaria | Drug: Pyronaridine-Artesunate | Medicines for Malaria Venture|Shin Poong Pharmaceuticals|Institute of Tropical Medicine, University of Tuebingen | Phase 2 | 2006-06-01 | 2008-05-19 |
NCT01594931 | Plasmodium Falciparum Malaria | Drug: pyronaridine/artesunate | Medicines for Malaria Venture|Shin Poong Pharmaceutical Co. Ltd. | Phase 2 | 2005-07-01 | 2012-05-08 |
NCT01204411 | Malaria, Falciparum|Malnutrition|Child | Drug: Artesunate-amodiaquine fixed-dose combination | Epicentre|Doctors Without Borders (Mdecins Sans Frontires OCBA, Barcelona, Spain) | Phase 4 | 2012-11-29 | |
NCT00875030 | Healthy Volunteers | Drug: artesunate sachets|Drug: Arsuamoon | Pfizer | Phase 4 | 2009-06-01 | 2010-06-07 |
NCT01868438 | Malaria | Drug: pyronaridine-artesunate granules|Drug: Pyronaridine-artesunate tablets | Medicines for Malaria Venture|Shin Poong Pharmaceutical Co. Ltd. | Phase 1 | 2013-05-01 | 2014-03-28 |
NCT02741024 | Malaria | Drug: Amodiaquine-Artesunate (ASAQ)|Drug: Artemether-Lumefantrine (AL) | Medecins Sans Frontieres, Netherlands | Phase 4 | 2013-10-01 | 2016-04-12 |
NCT02092766 | Anaemia | Drug: artesunate|Drug: quinine | University of Oxford|Kinshasa School of Public Health | Phase 4 | 2014-06-01 | 2015-05-29 |
NCT01082718 | Malaria|Pregnancy | Drug: Mefloquine Artesunate | Centers for Disease Control and Prevention | Phase 2|Phase 3 | 2010-03-01 | 2012-04-12 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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