Yohimbine hydrochloride 是α-2肾上腺素能受体抑制剂,阻断突触前或突触后的α-2肾上腺素能受体,引起去甲肾上腺素和多巴胺的释放。
Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Ernst E, et al. J Urol, 1998, 159(2), 433-436.
分子式 C21H27ClN2O3 |
分子量 390.9 |
CAS号 65-19-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 30 mM |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00975325 | Erectile Dysfunction | Drug: Yohimbine|Drug: Yohimbine | Walter Ritter GmbH & Co | Phase 4 | 2009-10-01 | 2015-06-25 |
NCT01593215 | Type 2 Diabetes | Drug: Yohimbine | Anders Rosengren, MD PhD|Region Skane|Lund University | Phase 2 | 2012-05-01 | 2015-01-07 |
NCT00078715 | Depression, Involutional|Major Depresssion | Drug: Yohimbine hydrochloride|Drug: Placebo | National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2004-03-01 | 2012-08-16 |
NCT00958880 | Social Anxiety Disorder | Behavioral: Group Cognitive Behavioral Therapy|Drug: Yohimbine Hydrochloride|Drug: Sugar Pill | Southern Methodist University | Phase 3 | 2009-03-01 | 2013-09-06 |
NCT00734422 | Phobic Disorders | Behavioral: Virtual Reality Exposure Therapy | VU University of Amsterdam | Phase 2|Phase 3 | 2008-07-01 | 2011-08-03 |
NCT00217048 | Healthy Volunteers | Drug: Yohimbine, oral | Mayo Clinic|National Institutes of Health (NIH) | Phase 1|Phase 2 | 2005-06-01 | 2009-04-27 |
NCT01031979 | Post-Traumatic Stress Disorder | Drug: Yohimbine|Drug: Placebo | VA Office of Research and Development | Phase 2 | 2010-12-01 | 2017-01-03 |
NCT00042536 | Erectile Dysfunction | Drug: Naltrexone HCL/ Yohimbine HCL | National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) | 2002-07-01 | 2008-03-03 | |
NCT00814047 | Blood Flow Velocity|Autoregulation|Ocular Physiology | Drug: Yohimbine hydrochloride | Medical University of Vienna | Phase 4 | 2008-12-22 | |
NCT00535002 | Cocaine Related Disorders | Drug: Yohimbine|Drug: Placebo | Medical University of South Carolina|National Institute on Drug Abuse (NIDA)|Office of Research on Women's Health (ORWH) | 2007-09-01 | 2013-03-27 | |
NCT01536925 | Heroin Dependence|Opioid-Related Disorders | Wayne State University|National Institute on Drug Abuse (NIDA) | 2011-12-01 | 2016-11-01 | ||
NCT00605904 | Alcoholism | Drug: Acamprosate|Drug: Yohimbine|Drug: mCPP|Drug: Saline | National Institute on Alcohol Abuse and Alcoholism (NIAAA)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2008-01-01 | 2012-05-23 |
NCT02963181 | Hypotension, Orthostatic|Hypertension|Autonomic Nervous System Diseases | Drug: Yohimbine|Drug: Melatonin | Lawson Health Research Institute | Early Phase 1 | 2017-01-01 | 2016-11-14 |
NCT02578849 | Parkinsons Disease | Drug: L-DOPA | Aarhus University Hospital|University of Copenhagen | 2012-01-01 | 2015-10-15 | |
NCT00032838 | Healthy | Drug: Yohimbine | National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) | 2002-03-01 | 2008-03-03 | |
NCT02470026 | Major Depressive Disorder|Early Life Trauma | Drug: yohimbine|Drug: placebo | Charite University, Berlin, Germany | 2014-06-01 | 2016-01-27 | |
NCT00029627 | Healthy | Drug: Yohimbine | National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) | 2002-01-01 | 2008-03-03 | |
NCT00709956 | Pulmonary Arterial Hypertension | Drug: iloprost (5 g)|Drug: placebo | Actelion | Phase 3 | 2008-07-01 | 2015-09-10 |
NCT00709098 | Pulmonary Arterial Hypertension | Drug: iloprost|Drug: iloprost | Actelion | Phase 3 | 2008-09-01 | 2015-09-10 |
NCT02007694 | Phobic Disorders | Behavioral: Virtual Reality Exposure Therapy (VRET) | VU University of Amsterdam | Phase 2|Phase 3 | 2013-03-01 | 2015-07-06 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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