Yohimbine HCl

盐酸育亨宾,Antagonil

Yohimbine hydrochloride 是α-2肾上腺素能受体抑制剂,阻断突触前或突触后的α-2肾上腺素能受体,引起去甲肾上腺素和多巴胺的释放。

目录号
EY1341
EY1341
EY1341
纯度
99.67%
99.67%
99.67%
规格
50 mg
100 mg
500 mg
原价
120
200
380
售价
120
200
380
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Ernst E, et al. J Urol, 1998, 159(2), 433-436.

    分子式
    C21H27ClN2O3
    分子量
    390.9
    CAS号
    65-19-0
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    30 mM
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00975325 Erectile Dysfunction Drug: Yohimbine|Drug: Yohimbine Walter Ritter GmbH & Co Phase 4 2009-10-01 2015-06-25
    NCT01593215 Type 2 Diabetes Drug: Yohimbine Anders Rosengren, MD PhD|Region Skane|Lund University Phase 2 2012-05-01 2015-01-07
    NCT00078715 Depression, Involutional|Major Depresssion Drug: Yohimbine hydrochloride|Drug: Placebo National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) Phase 2 2004-03-01 2012-08-16
    NCT00958880 Social Anxiety Disorder Behavioral: Group Cognitive Behavioral Therapy|Drug: Yohimbine Hydrochloride|Drug: Sugar Pill Southern Methodist University Phase 3 2009-03-01 2013-09-06
    NCT00734422 Phobic Disorders Behavioral: Virtual Reality Exposure Therapy VU University of Amsterdam Phase 2|Phase 3 2008-07-01 2011-08-03
    NCT00217048 Healthy Volunteers Drug: Yohimbine, oral Mayo Clinic|National Institutes of Health (NIH) Phase 1|Phase 2 2005-06-01 2009-04-27
    NCT01031979 Post-Traumatic Stress Disorder Drug: Yohimbine|Drug: Placebo VA Office of Research and Development Phase 2 2010-12-01 2017-01-03
    NCT00042536 Erectile Dysfunction Drug: Naltrexone HCL/ Yohimbine HCL National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) 2002-07-01 2008-03-03
    NCT00814047 Blood Flow Velocity|Autoregulation|Ocular Physiology Drug: Yohimbine hydrochloride Medical University of Vienna Phase 4 2008-12-22
    NCT00535002 Cocaine Related Disorders Drug: Yohimbine|Drug: Placebo Medical University of South Carolina|National Institute on Drug Abuse (NIDA)|Office of Research on Women's Health (ORWH) 2007-09-01 2013-03-27
    NCT01536925 Heroin Dependence|Opioid-Related Disorders Wayne State University|National Institute on Drug Abuse (NIDA) 2011-12-01 2016-11-01
    NCT00605904 Alcoholism Drug: Acamprosate|Drug: Yohimbine|Drug: mCPP|Drug: Saline National Institute on Alcohol Abuse and Alcoholism (NIAAA)|National Institutes of Health Clinical Center (CC) Phase 2 2008-01-01 2012-05-23
    NCT02963181 Hypotension, Orthostatic|Hypertension|Autonomic Nervous System Diseases Drug: Yohimbine|Drug: Melatonin Lawson Health Research Institute Early Phase 1 2017-01-01 2016-11-14
    NCT02578849 Parkinsons Disease Drug: L-DOPA Aarhus University Hospital|University of Copenhagen 2012-01-01 2015-10-15
    NCT00032838 Healthy Drug: Yohimbine National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) 2002-03-01 2008-03-03
    NCT02470026 Major Depressive Disorder|Early Life Trauma Drug: yohimbine|Drug: placebo Charite University, Berlin, Germany 2014-06-01 2016-01-27
    NCT00029627 Healthy Drug: Yohimbine National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) 2002-01-01 2008-03-03
    NCT00709956 Pulmonary Arterial Hypertension Drug: iloprost (5 g)|Drug: placebo Actelion Phase 3 2008-07-01 2015-09-10
    NCT00709098 Pulmonary Arterial Hypertension Drug: iloprost|Drug: iloprost Actelion Phase 3 2008-09-01 2015-09-10
    NCT02007694 Phobic Disorders Behavioral: Virtual Reality Exposure Therapy (VRET) VU University of Amsterdam Phase 2|Phase 3 2013-03-01 2015-07-06

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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