Home > DNA Methyltransferase & > Thioguanine

Thioguanine

6-硫鸟嘌呤,6-TG,2-Amino-6-mercaptopurine,2-Amino-6-purinethiol

Thioguanine是一种嘌呤类的抗代谢药物，广泛用于治疗急性淋巴细胞白血病，自身免疫性疾病（如克罗恩氏病，类风湿关节炎）和器官移植接受患者。

目录号
EY1340
EY1340
纯度
99.26%
99.26%
规格
100 mg
500 mg
原价
420
860
售价
420
860
库存
现货
现货
订购
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  • 生物活性

    Thioguanine, a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Krynetskaia NF, et al. FASEB J,2000, 14(14), 2339-2344.

    分子式
    C5H5N5S    		 分子量
    167.19    		 CAS号
    154-42-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    100 mM    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02141100 Non-Hodgkin Lymphoma Drug: 6-thioguanine Kjeld Schmiegelow|Aalborg Universitetshospital|Aarhus University Hospital Skejby|Odense University Hospital|Rigshospitalet, Denmark Phase 1|Phase 2 2014-07-01 2016-10-06
    NCT00588536 Langerhans Cell Histiocytosis Drug: Methotrexate|Drug: 6-Thioguanine|Drug: Leucovorin Calcium Memorial Sloan Kettering Cancer Center Phase 2 1995-01-01 2015-04-16
    NCT00587873 Hodgkin's Disease Drug: Methotrexate|Drug: Leucovorin calcium|Drug: 6-Thioguanine Memorial Sloan Kettering Cancer Center Phase 2 1994-03-01 2009-06-10
    NCT02912676 Acute Lymphoblastic Leukemia Drug: Thioguanine (oral) Kjeld Schmiegelow|Danish Child Cancer Foundation|Nordic Society for Pediatric Hematology and Oncology|Rigshospitalet, Denmark Phase 1|Phase 2 2016-10-01 2016-11-03
    NCT00504660 Anaplastic Glioma of Brain|Glioblastoma Multiforme|Brain Cancer Drug: Capecitabine|Drug: Celecoxib (Celebrex)|Drug: Temozolomide|Drug: Lomustine|Drug: 6-Thioguanine M.D. Anderson Cancer Center Phase 2 2003-09-01 2011-12-06
    NCT00549848 Acute Lymphoblastic Leukemia Drug: Prednisone, Vincristine, Daunorubicin, PEG-L-asparaginase, Erwinia L-asparaginase, Doxorubicin, Cyclophosphamide, Cytarabine, Thioguanine|Drug: Clofarabine, Methotrexate, Mercaptopurine, Dexamethasone, Etoposide, Dasatinib St. Jude Children's Research Hospital|National Cancer Institute (NCI)|Enzon Pharmaceuticals, Inc.|National Institute of General Medical Sciences (NIGMS) Phase 3 2007-10-01 2016-08-29
    NCT03022747 Lymphoblastic Leukemia, Acute, Childhood Drug: Allopurinol|Drug: Standard treatment Vastra Gotaland Region Phase 2 2017-01-01 2017-01-11
    NCT00002744 Leukemia Drug: asparaginase|Drug: cyclophosphamide|Drug: cytarabine|Drug: daunorubicin hydrochloride|Drug: dexamethasone|Drug: doxorubicin hydrochloride|Drug: mercaptopurine|Drug: methotrexate|Drug: pegaspargase|Drug: prednisone|Drug: therapeutic hydrocortisone|Drug: thioguanine|Drug: vincristine sulfate|Radiation: low-LET cobalt-60 gamma ray therapy|Radiation: low-LET photon therapy Children's Oncology Group|National Cancer Institute (NCI) Phase 3 1996-05-01 2017-02-07
    NCT00849368 Inflammatory Bowel Disease Drug: Azathioprine / Allopurinol University of Zurich Phase 1 2009-01-01 2012-02-06
    NCT00184041 Acute Lymphoblastic Leukemia Drug: Daunorubicin, Vincristine, Prednisone, Methotrexate, PEG-Asparaginase, 6-Mercaptopurine, Cytoxan, Cytosine Arabinoside, VM-26 and 6-Thioguanine University of Southern California Phase 2 2004-07-01 2014-05-20
    NCT00866749 Lymphoblastic Leukemia|Lymphoblastic Lymphoma Drug: Daunorubicin|Drug: Vincristine|Drug: PEG-asparaginase|Drug: Intrathecal Methotrexate|Drug: Cyclophosphamide|Drug: Cytarabine|Drug: Mercaptopurine|Drug: Methotrexate|Drug: Doxorubicin|Drug: Thioguanine M.D. Anderson Cancer Center Phase 2 2006-09-01 2016-11-07
    NCT02598908 External Quality Control|Thiopurine S-methyl Transferase (TPMT) Other: Quality control - enzyme activity Sandwell & West Birmingham Hospitals NHS Trust|Birmingham Quality 2017-04-01 2016-10-19
    NCT00369317 Childhood Acute Basophilic Leukemia|Childhood Acute Eosinophilic Leukemia|Childhood Acute Erythroleukemia (M6)|Childhood Acute Megakaryocytic Leukemia (M7)|Childhood Acute Minimally Differentiated Myeloid Leukemia (M0)|Childhood Acute Monoblastic Leukemia (M5a)|Childhood Acute Monocytic Leukemia (M5b)|Childhood Acute Myeloblastic Leukemia With Maturation (M2)|Childhood Acute Myeloblastic Leukemia Without Maturation (M1)|Childhood Acute Myelomonocytic Leukemia (M4)|Childhood Myelodysplastic Syndromes|de Novo Myelodysplastic Syndromes|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies Drug: asparaginase|Drug: daunorubicin hydrochloride|Drug: cytarabine|Drug: thioguanine|Drug: etoposide|Other: laboratory biomarker analysis Children's Oncology Group|National Cancer Institute (NCI) Phase 3 2007-03-01 2017-02-07
    NCT00002944 Brain Tumors|Central Nervous System Tumors Drug: carboplatin|Drug: lomustine|Drug: procarbazine hydrochloride|Drug: thioguanine|Drug: vincristine sulfate Children's Oncology Group|National Cancer Institute (NCI) Phase 3 1997-04-01 2013-09-06
    NCT02828358 Acute Leukemia of Ambiguous Lineage|Childhood B Acute Lymphoblastic Leukemia|Mixed Phenotype Acute Leukemia Drug: Azacitidine|Drug: Cyclophosphamide|Drug: Cytarabine|Drug: Daunorubicin Hydrochloride|Drug: Dexamethasone|Drug: Hydrocortisone Sodium Succinate|Other: Laboratory Biomarker Analysis|Drug: Leucovorin Calcium|Drug: Mercaptopurine|Drug: Methotrexate|Drug: Pegaspargase|Other: Pharmacological Study|Drug: Prednisolone|Drug: Thioguanine|Drug: Vincristine Sulfate National Cancer Institute (NCI) 2016-12-01 2017-01-31
    NCT02660762 Leukaemia,Lymphoblastic Drug: Vincristine|Drug: Daunorubicin|Drug: Pegaspargase|Drug: Prednisone|Drug: Intrathecal Methotrexate|Drug: Cyclophosphamide|Drug: Cytarabine|Drug: 6-Mercaptopurine|Drug: Methotrexate|Drug: Etoposide|Drug: dexamethasone|Drug: thioguanine|Drug: intrathecal cytarabine Sun Yat-sen University Phase 2 2010-01-01 2016-10-19
    NCT00866307 B-cell Adult Acute Lymphoblastic Leukemia|B-cell Childhood Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia Drug: pegaspargase|Drug: cytarabine|Drug: vincristine sulfate|Drug: doxorubicin hydrochloride|Drug: cyclophosphamide|Drug: prednisone|Drug: dexamethasone|Drug: methotrexate|Drug: daunorubicin hydrochloride|Drug: mercaptopurine|Drug: thioguanine|Radiation: prophylactic cranial irradiation|Other: laboratory biomarker analysis Children's Oncology Group|National Cancer Institute (NCI) 2009-02-01 2017-02-07
    NCT00003593 Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms Drug: asparaginase|Drug: cytarabine|Drug: daunorubicin hydrochloride|Drug: methotrexate|Drug: therapeutic hydrocortisone|Drug: thioguanine Children's Oncology Group|National Cancer Institute (NCI) Phase 3 1999-06-01 2013-06-26
    NCT00109837 Leukemia Biological: filgrastim|Drug: cyclophosphamide|Drug: cytarabine|Drug: daunorubicin|Drug: dexamethasone|Drug: doxorubicin|Drug: leucovorin|Drug: mercaptopurine|Drug: methotrexate|Drug: mitoxantrone|Drug: Asparaginase|Drug: prednisone|Drug: thioguanine|Drug: vincristine|Radiation: radiation therapy|Drug: allopurinol|Drug: bactrim Southwest Oncology Group|National Cancer Institute (NCI) Phase 2 2005-04-01 2015-03-05
    NCT01432145 Breast Cancer|Ovarian Cancer Drug: 6-Mercaptopurine|Drug: Methotrexate University of Oxford Phase 2 2011-05-01 2015-05-27
    NCT00002816 Leukemia Drug: cytarabine|Drug: dexamethasone|Drug: etoposide|Drug: idarubicin|Drug: ifosfamide|Drug: leucovorin calcium|Drug: mesna|Drug: pegaspargase|Drug: therapeutic hydrocortisone|Drug: thioguanine|Drug: vincristine sulfate|Radiation: low-LET cobalt-60 gamma ray therapy|Radiation: low-LET electron therapy|Radiation: low-LET photon therapy|Drug: Methotrexate Children's Oncology Group|National Cancer Institute (NCI) Phase 3 1996-12-01 2013-08-21

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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