FPH2 (BRD-9424) 是一种小分子,可促进iPS衍生肝细胞的分化。
FPH2 (BRD-9424) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Shan J, et al. Nat Chem Biol. 2013, 9(8), 514-520.
分子式 |
分子量 |
CAS号 957485-64-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 70 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00001398 | Aplastic Anemia|Pancytopenia | Drug: Recombinant Methionyl Human Stem Cell Factor (r-metHuSCF) | National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) | Phase 1 | 1993-10-01 | 2008-03-03 |
NCT00005783 | Hemoglobin SC Disease|Sickle Cell Anemia | Drug: Recombinant-methionyl human stem cell factor | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) | Phase 1 | 2000-03-01 | 2008-03-03 |
NCT00058045 | Lymphoma | Biological: aldesleukin|Biological: recombinant human stem cell factor | Roswell Park Cancer Institute|National Cancer Institute (NCI) | Phase 1 | 2002-08-01 | 2013-01-30 |
NCT00434239 | Myelodysplasia | Drug: Lenalidomide + Ancestim | Peter MacCallum Cancer Centre, Australia|Celgene Corporation | Early Phase 1 | 2007-02-01 | 2013-01-08 |
NCT00005993 | Breast Cancer|Lymphoma | Drug: aldesleukin|Drug: filgrastim|Drug: recombinant human stem cell factor|Procedure: peripheral blood stem cell transplantation | Masonic Cancer Center, University of Minnesota|National Cancer Institute (NCI) | Phase 1 | 1999-05-01 | 2012-10-09 |
NCT01016795 | Malignant Lymphoma | Drug: r-metHuSCF and Filgrastim|Drug: r-metHuSCF and Filgrastim|Drug: Chemotherapy plus Filgrastim | Aalborg Universitetshospital|Herlev Hospital|Rigshospitalet, Denmark|Helsinki University Central Hospital|Turku University Hospital|University Hospital, Linkoeping|Ume University|Oslo University Hospital|Nordic Lymphoma Group|Amgen | Phase 2 | 1999-01-01 | 2015-06-24 |
NCT00001750 | Multiple Myeloma | Drug: Stemgen | National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) | Phase 2 | 1998-09-01 | 2008-03-03 |
NCT02553304 | Chronic Lymphocytic Leukemia (CLL) | National Health Research Institutes, Taiwan | 2015-09-01 | 2016-01-13 | ||
NCT00154466 | Myocardial Infarction | Behavioral: cardiac rehabilitation | National Taiwan University Hospital | 2004-07-01 | 2014-05-25 | |
NCT00001356 | Mastocytosis | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) | 1993-05-01 | 2008-03-03 | ||
NCT00216112 | Ovarian Cancer | Drug: Imatinib Mesylate|Drug: Docetaxel | Daniela Matei, MD|Novartis Pharmaceuticals|Sanofi|Walther Cancer Institute|Hoosier Cancer Research Network | Phase 2 | 2003-12-01 | 2016-02-17 |
NCT02461849 | Advanced, Refractory Cancer | Drug: Imatinib | Samsung Medical Center | Phase 2 | 2014-04-04 | 2017-02-15 |
NCT01440959 | Gastrointestinal Stromal Tumors | Drug: dovitinib | Asan Medical Center | Phase 2 | 2011-09-01 | 2014-01-13 |
NCT01563822 | Intra-cytoplasmic Sperm Injection Outcome | Biological: Follicular fluid | Nawara Mohamed Hashish|Kasr El Aini Hospital | Phase 1 | 2011-12-01 | 2012-10-06 |
NCT00731744 | Normal Full-Term Deliveries | Procedure: Normal full-term deliveries | National Taiwan University Hospital | 2007-01-01 | 2008-08-08 | |
NCT01222143 | Acute Myeloid Leukemia | Drug: NOVE-HiDAC|Drug: Nilotinib | University Health Network, Toronto|Novartis Pharmaceuticals | Phase 1|Phase 2 | 2010-10-01 | 2015-06-19 |
NCT02145897 | Critical Limb Ischemia | Biological: Autologous Stromal Vascular Fraction (SVF)|Biological: Autologous Adipose Derieved MSCs|Other: Control | Kasiak Research Pvt. Ltd. | Phase 1|Phase 2 | 2014-08-01 | 2014-05-20 |
NCT01172548 | Gastrointestinal Stromal Tumors | Drug: imatinib mesylate | Novartis Pharmaceuticals|Novartis | Phase 2 | 2008-08-01 | 2017-02-24 |
NCT01624701 | Acute Leukemia|Chronic Leukemia|Myelodysplastic Syndrome|Lymphoma|Myeloma | Other: Ex vivo expanded cord blood cells | Singapore General Hospital|Whitehead Institute for Biomedical Research|Blood Services Group, Health Sciences Authority of Singapore | Phase 1|Phase 2 | 2012-03-01 | 2015-11-26 |
NCT02148367 | Traumatic Brain Injury | Drug: Erythropoietin | Uniformed Services University of the Health Sciences|National Institutes of Health (NIH) | Phase 2 | 2014-09-01 | 2015-12-30 |
NCT00003957 | Lymphoma | Biological: filgrastim|Biological: recombinant human stem cell factor|Drug: cyclophosphamide|Drug: cytarabine|Drug: etoposide|Drug: melphalan|Drug: mitoxantrone hydrochloride|Drug: paclitaxel|Procedure: peripheral blood stem cell transplantation | Fox Chase Cancer Center|National Cancer Institute (NCI) | Phase 2 | 1998-12-01 | 2013-04-16 |
NCT03033953 | Healthy|Young|Elderly | Dietary Supplement: Native whey|Dietary Supplement: Milk|Other: Strength training | Norwegian School of Sport Sciences|Tine|The Research Council of Norway | 2014-08-01 | 2017-01-24 | |
NCT00001760 | Atopic Dermatitis|Healthy|Mastocytosis | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) | 1998-01-01 | 2007-12-12 | ||
NCT00457743 | Gastrointestinal Stromal Tumors | Drug: Sunitinib malate (SU011248) | Pfizer | Phase 1|Phase 2 | 2005-01-01 | 2009-10-02 |
NCT00569946 | Carcinoma, Renal Cell | Drug: AG-013736 | Pfizer | Phase 2 | 2007-12-01 | 2014-07-16 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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