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Daclatasvir

达卡他韦,EBP883,BMS-790052,EBP 883,EBP-883,BMS 790052,BMS790052,

Daclatasvir (BMS-790052; EBP 883)是首创的高选择性口服HCV NS5A抑制剂。

目录号
EY1326
EY1326
EY1326
EY1326
纯度
99.16%
99.16%
99.16%
99.16%
规格
1 mg
5 mg
10 mg
50 mg
原价
270
610
890
3500
售价
270
610
890
3500
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Daclatasvir (BMS-790052) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. Phase 3.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    0.1 pM-50 µM, 最终DMSO浓度0.5%

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Gao M, et al. Nature, 2010, 465(7294), 96-100.

    分子式
    C40H50N8O6
    分子量
    738.88
    CAS号
    1009119-64-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    200 mM
    Water
    <1 mg/mL
    Ethanol
    200 mM

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02865369 Chronic Hepatitis C Drug: Daclatasvir and Asunaprevir Sang Gyune Kim|Seoul National University Boramae Hospital|Severance Hospital|Inha University Hospital|Korea University|Gachon University Gil Medical Center|Hanyang University Seoul Hospital|Ewha Womans University Mokdong Hospital|Bristol-Myers Squibb|Soonchunhyang University Hospital 2016-09-01 2017-03-04
    NCT01830205 Hepatitis C Drug: Daclatasvir Bristol-Myers Squibb Phase 1 2012-09-01 2015-11-13
    NCT02032901 Hepatitis C Drug: Daclatasvir|Drug: Sofosbuvir Bristol-Myers Squibb Phase 3 2014-01-01 2015-09-29
    NCT03004625 Hepatitis C Drug: daclatasvir|Drug: asunaprevir|Drug: Ribavirin Kaohsiung Medical University Chung-Ho Memorial Hospital|Chang Gung Memorial Hospital|National Taiwan University Hospital|Taipei Veterans General Hospital, Taiwan|China Medical University Hospital|National Cheng-Kung University Hospital Phase 3 2016-11-01 2017-02-28
    NCT02159352 Hepatitis C Drug: Daclatasvir|Drug: Darunavir|Drug: Ritonavir|Drug: Lopinavir/Ritonavir Bristol-Myers Squibb Phase 1 2014-06-01 2015-10-29
    NCT02268864 Hepatitis C, Chronic Drug: Simeprevir|Drug: Daclatasvir Janssen-Cilag International NV Phase 2 2015-01-01 2017-02-07
    NCT02624063 Hepatitis C, Chronic Drug: Daclatasvir + Sofosbuvir|Drug: Simeprevir + Sofosbuvir Federal University of So Paulo Phase 4 2015-12-01 2017-02-17
    NCT02756936 Healthy Drug: Daclatasvir Zeta|Drug: Clatazev Genuine Research Center, Egypt|Zeta Pharma Pharmaceutical Industries Phase 1 2016-02-01 2017-02-27
    NCT02032888 Hepatitis C Drug: Daclatasvir|Drug: Sofosbuvir Bristol-Myers Squibb Phase 3 2014-02-01 2015-09-24
    NCT02551861 Hepatitis C Drug: Daclatasvir|Drug: Sofosbuvir|Drug: Ribavirin Bristol-Myers Squibb Phase 2 2015-12-01 2016-01-14
    NCT02565862 Hepatitis C|Diabetes Mellitus|Insulin Resistance Drug: Daclatasvir|Drug: Metformin Radboud University Phase 1 2016-01-01 2016-04-06
    NCT02675127 Healthy Drug: Daktavira|Drug: Daklinza Genuine Research Center, Egypt|European Egyptian Pharmaceutical Industries Phase 1 2015-12-01 2016-02-03
    NCT01492504 Hepatitis C Drug: Asunaprevir (BMS-650032) and/or Daclatasvir (BMS-790052) Bristol-Myers Squibb 2012-02-01 2017-03-03
    NCT03063879 Hepatitis C, Chronic|Chronic Renal Failure Drug: Sofosbuvir 400 mg and daclatasvir 60 mg Tehran University of Medical Sciences|Ahvaz Jundishapur University of Medical Sciences|Shiraz University of Medical Sciences|Isfahan University of Medical Sciences|Tabriz University of Medical Sciences Phase 4 2017-03-01 2017-02-23
    NCT02262728 Hepatitis C, Chronic Drug: Simeprevir|Drug: Daclatasvir|Drug: Sofosbuvir Janssen Research & Development, LLC Phase 2 2014-09-01 2016-12-19
    NCT02309450 Hepatitis C Virus Genotype 4 Infection Drug: .Asunaprevir, Daclatasvir and BMS - 791325 French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb Phase 2 2014-12-01 2016-02-01
    NCT02640157 Chronic Hepatitis C|Hepatitis C Virus|Genotype 3 Hepatitis C Virus Drug: ABT-493/ABT-530|Drug: sofosbuvir|Drug: daclatasvir|Drug: daclatasvir AbbVie Phase 3 2015-12-01 2017-02-08
    NCT02556086 Hepatitis C Drug: Daclatasvir|Drug: Sofosbuvir Bristol-Myers Squibb Phase 2 2015-12-01 2016-01-19
    NCT02580474 Hepatitis C Drug: Daclatasvir plus Asunaprevir Myeong Jun Song|Bristol-Myers Squibb|Soonchunhyang University Hospital|Dankook University|Chungnam National University Hospital|Konyang University Hospital|Eulji University Hospital|Saint Vincent's Hospital, Korea|Konkuk University Hospital|Cheongju St. Mary's Hospital, Cheongju, Korea|Severance Hospital|Korea University Guro Hospital|Eulji General Hospital|The Catholic University of Korea Phase 4 2016-02-01 2016-02-24
    NCT02496078 Hepatitis C Drug: Daclatasvir|Drug: Asunaprevir Bristol-Myers Squibb Phase 3 2015-08-01 2017-03-03

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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