Home > Topoisomerase & > Levofloxacin

Levofloxacin

左氧氟沙星,Fluoroquinolone

Levofloxacin是合成的氟喹诺酮类抗生素,能抑制细菌DNA旋转酶的超螺旋活性,可阻止DNA复制。

目录号
EY1318
EY1318
纯度
99.35%
99.35%
规格
100 mg
500 mg
原价
420
620
售价
420
620
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Davis R, et al. Drugs,?994, 47(4), 677-700.

    分子式
    C18H20FN3O4
    分子量
    361.37
    CAS号
    100986-85-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    25 mg/mL
    Water
    10 mg/mL
    Ethanol
    7 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00176306 Obesity|Critical Illness Drug: Levofloxacin 750 mg IV University of Kentucky|Ortho-McNeil Pharmaceutical Phase 4 2005-01-01 2012-09-12
    NCT02018081 Intensive Care Unit Syndrome|Community-acquired Pneumonia Drug: Levofloxacin University Hospital, Toulouse Phase 4 2012-03-01 2015-03-04
    NCT01055145 TB Drug: levofloxacin, moxifloxacin Seoul National University Hospital Phase 3 2010-03-01 2012-11-22
    NCT00645437 Renal Diseases Drug: Levofloxacin Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Phase 1 2004-10-01 2011-06-06
    NCT01371656 Acute Leukemias of Ambiguous Lineage|Bacterial Infection|Diarrhea|Fungal Infection|Musculoskeletal Complications|Neutropenia|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies Drug: levofloxacin Children's Oncology Group|National Cancer Institute (NCI) Phase 3 2011-06-01 2017-02-13
    NCT01761201 Latent Tuberculosis Infection|Infection in Solid Organ Transplant Recipients Drug: Levofloxacin|Drug: Isoniazid Fundacin Pblica Andaluza para la gestin de la Investigacin en Sevilla|Spanish Network for Research in Infectious Diseases Phase 3 2012-01-01 2014-08-05
    NCT01575899 Helicobacter Pylori Infection Drug: Levofloxacin-Amox/clav.|Drug: Clarithromycin-Amoxicillin Buddhist Tzu Chi General Hospital Phase 4 2007-12-01 2012-07-28
    NCT00764582 Corneal Transplantation Drug: 1.5% levofloxacin ophthalmic solution|Drug: 0.5% moxifloxacin ophthalmic solution Santen Inc.|Vistakon Pharmaceuticals Phase 4 2008-09-01 2009-08-24
    NCT02884713 GASTRITIS Drug: Levofloxacin|Drug: Doxycycline|Drug: Esomeprazole King Faisal Specialist Hospital & Research Center 2013-06-01 2016-08-25
    NCT01168713 Community-Acquired Bacterial Pneumonia Drug: Levofloxacin|Drug: CEM-101 Cempra Inc Phase 2 2010-08-01 2017-03-01
    NCT01537055 Eradication Rate for Helicobacter Drug: levofloxacin-based sequential therapy|Drug: levofloxacin-based triple therapy for 10 days National Taiwan University Hospital|E-DA Hospital Phase 4 2012-02-01 2015-01-30
    NCT01710488 COPD Exacerbation Drug: Levofloxacin 1 tablet 500 mg once a day|Drug: Prulifloxacin 1 tablet 600 mg once a day Fadoi Foundation, Italy Phase 4 2009-05-01 2017-01-11
    NCT01529476 Pneumonia Drug: Levofloxacin|Drug: Nemonoxacin TaiGen Biotechnology Co., Ltd.|Qualitix Clinical Research Co., Ltd.|Parexel|PPD Phase 3 2011-04-01 2013-06-17
    NCT01978938 Complicated Urinary Tract Infections (cUTI) Drug: Eravacycline|Drug: Levofloxacin Tetraphase Pharmaceuticals, Inc. Phase 3 2013-12-01 2016-05-24
    NCT01524302 Pneumonia, Bacterial|Community-acquired Drug: Ceftaroline|Drug: Levofloxacin Gary E. Stein, Pharm.D.|Forest Laboratories|Michigan State University Phase 4 2012-02-01 2016-03-14
    NCT01467297 COPD Exacerbation Drug: ceftidoren|Drug: levofloxacin University of Milan Phase 4 2012-01-01 2012-06-02
    NCT00035347 Community-Acquired Pneumonia (CAP) Drug: IV azithromycin|Drug: ceftriaxone|Drug: oral azithromycin|Drug: IV levofloxacin|Drug: oral levofloxacin Pfizer Phase 4 2001-01-01 2017-03-07
    NCT00376376 Healthy Volunteers Drug: levofloxacin at 250, 500, 750, and 1000 mg doses Michigan State University|PriCara, Unit of Ortho-McNeil, Inc. 2006-09-01 2008-11-25
    NCT02699658 Healthy Volunteers Drug: Levofloxacin Prince of Songkla University Phase 2 2013-10-01 2016-03-03
    NCT01345929 Complicated Urinary Tract Infection|Pyelonephritis Drug: CXA-201|Drug: Levofloxacin Cubist Pharmaceuticals LLC Phase 3 2011-06-01 2016-01-06
    NCT00565123 Bacterial Conjunctivitis Drug: 0.5% levofloxacin eye drops|Drug: 0.5% levofloxacin eye drops Laser Microsurgery Centre, Poland|Katedra I Klinika Okulistyki II Wydz. Lek. AM w Warszawie,|University Hospital No 1 Wroclaw|MedSource Polska Phase 2|Phase 3 2004-09-01 2007-11-28
    NCT03038321 Non-Muscle-invasive Bladder Cancer (NMIBC)|Bacillus Calmette-Guerin (BCG) Cystitis|Intra-vesical Instillation Drug: sofenacin|Drug: Tavanic|Drug: Xefo Mansoura University Phase 4 2017-02-01 2017-03-20
    NCT00906048 Infection Drug: Levofloxacin (HR355) and Rifampicin Therapy Sanofi Phase 3 2009-04-01 2011-02-04
    NCT00495339 Tuberculosis, Pulmonary Drug: Levofloxacin Sanofi Phase 4 2007-06-01 2009-03-03
    NCT00453349 Pelvic Inflammatory Disease Drug: Moxifloxacin (Avelox, BAY12-8039)|Drug: Levofloxacin & Metronidazole Bayer Phase 3 2007-01-01 2014-09-02

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :