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Droperidol

氟哌利多,NSC 169874,NSC-169874,NSC169874

Droperidol是一种丁酰苯类的Dopamine-2受体拮抗剂。

目录号
EY1313
纯度
99.24%
规格
100 mg
原价
380
售价
380
库存
现货
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  • 生物活性

    Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Kao LW, et al. Ann Emerg Med, 2003, 41(4), 546-558.

    分子式
    C22H22FN3O2
    分子量
    379.43
    CAS号
    548-73-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    200 mM
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00445055 Nausea|Vomiting Drug: Droperidol University Hospital, Bordeaux|Prostrakan Pharmaceuticals Phase 4 2007-04-01 2011-12-12
    NCT00702442 Vomiting Drug: Droperidol|Drug: Saline solution Aristotle University Of Thessaloniki|AHEPA University Hospital Phase 4 2008-06-01 2011-07-25
    NCT01406860 Primary Headaches (Includes Migraines, Tension, Cluster Headaches) Drug: Droperidol|Drug: Metoclopramide|Drug: Diphenhydramine University of Iowa 2011-07-01 2017-03-16
    NCT00624208 Myocardial Repolarization Drug: droperidol and saline|Drug: ondansetron and saline|Drug: droperidol and ondansetron|Drug: saline and saline University of British Columbia|British Columbia Childrens Hospital Foundation 2008-02-01 2009-08-17
    NCT01819857 Cardiac Repolarization Drug: Xomolix 0.625 mg intravenously|Drug: Xomolix 1.25 mg|Drug: Zofran 8 mg Medical University of Gdansk Phase 4 2011-06-01 2013-08-05
    NCT01739985 Postoperative Vomiting Drug: Dexamethasone + ondansetron + Placebo|Drug: Dexamethasone + ondansetron + Droperidol Assistance Publique - H么pitaux de Paris 2010-12-01 2014-07-25
    NCT01942343 Akathisia Drug: Droperidol 1,25 mg administration, Droperidol 0,625 mg administration, Odansetron 4 mg administration University Hospital, Strasbourg, France Phase 3 2013-10-01 2013-09-12
    NCT02744495 Postoperative Vomiting|Postoperative Nausea|Postoperative Emesis Drug: Betamethasone|Drug: Droperidol H么pital Priv de Parly II - Le Chesnay Phase 3 2016-02-01 2016-12-13
    NCT01679093 Interaction Between Antiemetic Drugs and Paracetamol Drug: ondansetron|Drug: Droperidol|Drug: Dexamethasone University Hospital, Lille Phase 3 2009-06-01 2016-10-26
    NCT01434017 Postoperative Nausea and Vomiting Drug: Dexamethasone|Drug: Dexamethasone and droperidol|Drug: Dexamethasone and Ondansetron Centre Hospitalier Universitaire Vaudois Phase 4 2008-11-01 2014-02-26
    NCT01432977 Pain Drug: paracetamol /droperidol|Drug: paracetamol / ondansetron University Hospital, Limoges Phase 3 2011-09-01 2012-10-30
    NCT02282956 Hallux Valgus Drug: Ropivacaine 0,75%|Procedure: posterior tibial nerve block|Drug: morphine and droperidol Dr.med. Sabine Schoenfeld|Spitalregion Rheintal, Werdenberg, Sarganserland Phase 4 2014-10-01 2016-04-29
    NCT03023462 Inguinal Hernia|Pain, Postoperative Drug: Oksykodonhydroklorid|Drug: Ketobemidone Hydrochloride|Drug: Ondansetron and Droperidol|Drug: Ropivacaine Ostfold Hospital Trust Phase 4 2017-02-01 2017-01-23
    NCT02078336 Dental Care for Disabled Drug: Midazolam Mylan|Drug: Lorazepam Mylan|Drug: Valium + Akineton + Dehydrobenzperidol + Atropine sulfate Universitaire Ziekenhuizen Leuven Phase 4 2013-12-01 2014-02-28
    NCT01592708 Post-operative Nausea|Post-operative Vomiting|Nausea Persistent Other: Antiemetic anesthesia protocol University of North Carolina, Chapel Hill|National Institute of Dental and Craniofacial Research (NIDCR) 2012-06-01 2014-08-15
    NCT00209885 Cholecystolithiasis Drug: Gabapentin|Drug: S-ketamine|Drug: Lidocaine|Drug: Droperidol Hvidovre University Hospital Phase 4 2005-10-01 2005-09-14
    NCT01765829 Psychosis Nos/Other Drug: Discontinuation antipsychotic treatment|Drug: Antipsychotic treatment Fundacin Pblica Andaluza Progreso y Salud|Instituto de Salud Carlos III|Andalusian Initiative for Advanced Therapies - Fundacin Pblica Andaluza Progreso y Salud Phase 3 2012-11-01 2014-12-04
    NCT01594749 Chemotherapy-Induced Nausea and Vomiting (CINV) Drug: Fosaprepitant dimeglumine|Drug: Fosaprepitant Placebo|Drug: Dexamethasone|Drug: Ondansetron|Drug: Dexamethasone Placebo|Drug: Ondansetron Placebo|Drug: Rescue Therapy Merck Sharp & Dohme Corp. Phase 3 2012-09-01 2017-02-17
    NCT01470846 Extended Ileal Resection Under Laparotomy|Total Proctocolectomy Under Laparotomy|Colectomy Left/Right/Total Under Laparotomy|Rectosigmoidal Resection Under Laparotomy|Anterior Resection of Rectum Under Laparotomy|Abdomino-perineal Amputation Under Laparotomy Procedure: epidural analgesia|Procedure: PCA University Hospital, Limoges Phase 4 2011-11-01 2014-08-13
    NCT01303809 Morbid Obesity Other: Enhanced Recovery After Surgey for Sleeve Gastrectomy University of Auckland, New Zealand|Auckland Medical Research Foundation 2011-05-01 2012-05-24
    NCT02600741 Schizophrenia Other: Caregiver psycho-education and skills training|Other: Caregiver support available at the study site|Drug: Paliperidone palmitate|Drug: Chlorpromazine|Drug: Droperidol|Drug: Fluphenazine|Drug: Haloperidol|Drug: Loxapine|Drug: Perphenazine|Drug: Pimozide|Drug: Prochlorperazine|Drug: Thiothixene|Drug: Thioridazine|Drug: Trifluoperazine|Drug: Aripiprazole|Drug: Asenapine|Drug: Clozapine|Drug: Iloperidone|Drug: Olanzapine|Drug: Paliperidone|Drug: Quetiapine|Drug: Risperidone|Drug: Ziprasidone Janssen Scientific Affairs, LLC 2015-07-24 2017-03-17
    NCT02625181 Postoperative Nausea and Vomiting Procedure: Automated recommendation at the start of the case|Procedure: Automated notification at the start of surgery|Procedure: Preoperative recommendations: by email|Procedure: Automated notification at the end of surgery|Device: Anesthesia Information Management System (AIMS)|Device: Perioperative Data Warehouse (PDW)|Procedure: General anesthesia|Procedure: Elective surgery|Drug: Propofol|Drug: Sevoflurane|Drug: Isoflurane|Drug: Desflurane|Drug: Scopolamine|Drug: Droperidol|Drug: Haloperidol|Drug: Dexamethasone|Drug: Promethazine|Drug: Meclizine|Drug: Aprepitant|Drug: Metoclopramide|Drug: Fentanyl|Drug: Sufentanil|Drug: Alfentanil|Drug: Remifentanil|Drug: Morphine|Drug: Meperidine|Drug: Hydromorphone|Drug: Methadone|Drug: Oxycodone|Drug: Oxymorphone|Drug: Hydrocodone|Drug: Ketamine|Drug: Ondansetron|Drug: Granisetron|Drug: Dolasetron mesylate|Drug: Palonosetron|Drug: Tropisetron|Drug: Ramosetron Vanderbilt University|University of Washington|Vanderbilt University Medical Center 2016-07-01 2017-03-23
    NCT03036514 Pain, Postoperative Drug: Sublingual sufentanil tablet system|Drug: Patient-controlled intravenous analgesia University Hospital, Antwerp|Universiteit Antwerpen 2017-04-01 2017-03-21
    NCT03064165 Obturator Nerve Block|Total Hip Replacement Drug: Bupivacaine-epinephrine|Procedure: Sham block|Procedure: Obturator nerve block|Drug: Sodium Chloride 9mg/mL University of Aarhus|Elective Surgery Centre, Silkeborg Regional Hospital Phase 4 2017-05-01 2017-02-23

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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