Droperidol是一种丁酰苯类的Dopamine-2受体拮抗剂。
Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Kao LW, et al. Ann Emerg Med, 2003, 41(4), 546-558.
分子式 C22H22FN3O2 |
分子量 379.43 |
CAS号 548-73-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 200 mM |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00445055 | Nausea|Vomiting | Drug: Droperidol | University Hospital, Bordeaux|Prostrakan Pharmaceuticals | Phase 4 | 2007-04-01 | 2011-12-12 |
NCT00702442 | Vomiting | Drug: Droperidol|Drug: Saline solution | Aristotle University Of Thessaloniki|AHEPA University Hospital | Phase 4 | 2008-06-01 | 2011-07-25 |
NCT01406860 | Primary Headaches (Includes Migraines, Tension, Cluster Headaches) | Drug: Droperidol|Drug: Metoclopramide|Drug: Diphenhydramine | University of Iowa | 2011-07-01 | 2017-03-16 | |
NCT00624208 | Myocardial Repolarization | Drug: droperidol and saline|Drug: ondansetron and saline|Drug: droperidol and ondansetron|Drug: saline and saline | University of British Columbia|British Columbia Childrens Hospital Foundation | 2008-02-01 | 2009-08-17 | |
NCT01819857 | Cardiac Repolarization | Drug: Xomolix 0.625 mg intravenously|Drug: Xomolix 1.25 mg|Drug: Zofran 8 mg | Medical University of Gdansk | Phase 4 | 2011-06-01 | 2013-08-05 |
NCT01739985 | Postoperative Vomiting | Drug: Dexamethasone + ondansetron + Placebo|Drug: Dexamethasone + ondansetron + Droperidol | Assistance Publique - H么pitaux de Paris | 2010-12-01 | 2014-07-25 | |
NCT01942343 | Akathisia | Drug: Droperidol 1,25 mg administration, Droperidol 0,625 mg administration, Odansetron 4 mg administration | University Hospital, Strasbourg, France | Phase 3 | 2013-10-01 | 2013-09-12 |
NCT02744495 | Postoperative Vomiting|Postoperative Nausea|Postoperative Emesis | Drug: Betamethasone|Drug: Droperidol | H么pital Priv de Parly II - Le Chesnay | Phase 3 | 2016-02-01 | 2016-12-13 |
NCT01679093 | Interaction Between Antiemetic Drugs and Paracetamol | Drug: ondansetron|Drug: Droperidol|Drug: Dexamethasone | University Hospital, Lille | Phase 3 | 2009-06-01 | 2016-10-26 |
NCT01434017 | Postoperative Nausea and Vomiting | Drug: Dexamethasone|Drug: Dexamethasone and droperidol|Drug: Dexamethasone and Ondansetron | Centre Hospitalier Universitaire Vaudois | Phase 4 | 2008-11-01 | 2014-02-26 |
NCT01432977 | Pain | Drug: paracetamol /droperidol|Drug: paracetamol / ondansetron | University Hospital, Limoges | Phase 3 | 2011-09-01 | 2012-10-30 |
NCT02282956 | Hallux Valgus | Drug: Ropivacaine 0,75%|Procedure: posterior tibial nerve block|Drug: morphine and droperidol | Dr.med. Sabine Schoenfeld|Spitalregion Rheintal, Werdenberg, Sarganserland | Phase 4 | 2014-10-01 | 2016-04-29 |
NCT03023462 | Inguinal Hernia|Pain, Postoperative | Drug: Oksykodonhydroklorid|Drug: Ketobemidone Hydrochloride|Drug: Ondansetron and Droperidol|Drug: Ropivacaine | Ostfold Hospital Trust | Phase 4 | 2017-02-01 | 2017-01-23 |
NCT02078336 | Dental Care for Disabled | Drug: Midazolam Mylan|Drug: Lorazepam Mylan|Drug: Valium + Akineton + Dehydrobenzperidol + Atropine sulfate | Universitaire Ziekenhuizen Leuven | Phase 4 | 2013-12-01 | 2014-02-28 |
NCT01592708 | Post-operative Nausea|Post-operative Vomiting|Nausea Persistent | Other: Antiemetic anesthesia protocol | University of North Carolina, Chapel Hill|National Institute of Dental and Craniofacial Research (NIDCR) | 2012-06-01 | 2014-08-15 | |
NCT00209885 | Cholecystolithiasis | Drug: Gabapentin|Drug: S-ketamine|Drug: Lidocaine|Drug: Droperidol | Hvidovre University Hospital | Phase 4 | 2005-10-01 | 2005-09-14 |
NCT01765829 | Psychosis Nos/Other | Drug: Discontinuation antipsychotic treatment|Drug: Antipsychotic treatment | Fundacin Pblica Andaluza Progreso y Salud|Instituto de Salud Carlos III|Andalusian Initiative for Advanced Therapies - Fundacin Pblica Andaluza Progreso y Salud | Phase 3 | 2012-11-01 | 2014-12-04 |
NCT01594749 | Chemotherapy-Induced Nausea and Vomiting (CINV) | Drug: Fosaprepitant dimeglumine|Drug: Fosaprepitant Placebo|Drug: Dexamethasone|Drug: Ondansetron|Drug: Dexamethasone Placebo|Drug: Ondansetron Placebo|Drug: Rescue Therapy | Merck Sharp & Dohme Corp. | Phase 3 | 2012-09-01 | 2017-02-17 |
NCT01470846 | Extended Ileal Resection Under Laparotomy|Total Proctocolectomy Under Laparotomy|Colectomy Left/Right/Total Under Laparotomy|Rectosigmoidal Resection Under Laparotomy|Anterior Resection of Rectum Under Laparotomy|Abdomino-perineal Amputation Under Laparotomy | Procedure: epidural analgesia|Procedure: PCA | University Hospital, Limoges | Phase 4 | 2011-11-01 | 2014-08-13 |
NCT01303809 | Morbid Obesity | Other: Enhanced Recovery After Surgey for Sleeve Gastrectomy | University of Auckland, New Zealand|Auckland Medical Research Foundation | 2011-05-01 | 2012-05-24 | |
NCT02600741 | Schizophrenia | Other: Caregiver psycho-education and skills training|Other: Caregiver support available at the study site|Drug: Paliperidone palmitate|Drug: Chlorpromazine|Drug: Droperidol|Drug: Fluphenazine|Drug: Haloperidol|Drug: Loxapine|Drug: Perphenazine|Drug: Pimozide|Drug: Prochlorperazine|Drug: Thiothixene|Drug: Thioridazine|Drug: Trifluoperazine|Drug: Aripiprazole|Drug: Asenapine|Drug: Clozapine|Drug: Iloperidone|Drug: Olanzapine|Drug: Paliperidone|Drug: Quetiapine|Drug: Risperidone|Drug: Ziprasidone | Janssen Scientific Affairs, LLC | 2015-07-24 | 2017-03-17 | |
NCT02625181 | Postoperative Nausea and Vomiting | Procedure: Automated recommendation at the start of the case|Procedure: Automated notification at the start of surgery|Procedure: Preoperative recommendations: by email|Procedure: Automated notification at the end of surgery|Device: Anesthesia Information Management System (AIMS)|Device: Perioperative Data Warehouse (PDW)|Procedure: General anesthesia|Procedure: Elective surgery|Drug: Propofol|Drug: Sevoflurane|Drug: Isoflurane|Drug: Desflurane|Drug: Scopolamine|Drug: Droperidol|Drug: Haloperidol|Drug: Dexamethasone|Drug: Promethazine|Drug: Meclizine|Drug: Aprepitant|Drug: Metoclopramide|Drug: Fentanyl|Drug: Sufentanil|Drug: Alfentanil|Drug: Remifentanil|Drug: Morphine|Drug: Meperidine|Drug: Hydromorphone|Drug: Methadone|Drug: Oxycodone|Drug: Oxymorphone|Drug: Hydrocodone|Drug: Ketamine|Drug: Ondansetron|Drug: Granisetron|Drug: Dolasetron mesylate|Drug: Palonosetron|Drug: Tropisetron|Drug: Ramosetron | Vanderbilt University|University of Washington|Vanderbilt University Medical Center | 2016-07-01 | 2017-03-23 | |
NCT03036514 | Pain, Postoperative | Drug: Sublingual sufentanil tablet system|Drug: Patient-controlled intravenous analgesia | University Hospital, Antwerp|Universiteit Antwerpen | 2017-04-01 | 2017-03-21 | |
NCT03064165 | Obturator Nerve Block|Total Hip Replacement | Drug: Bupivacaine-epinephrine|Procedure: Sham block|Procedure: Obturator nerve block|Drug: Sodium Chloride 9mg/mL | University of Aarhus|Elective Surgery Centre, Silkeborg Regional Hospital | Phase 4 | 2017-05-01 | 2017-02-23 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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