Granisetron Hydrochloride是5-HT3受体拮抗剂,可作为化疗后止吐剂。
Granisetron is a serotonin 5-HT3 receptor antagonist,used to treat chemotherapy-induced nausea and vomiting.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] de Lorenzi FG, et al. Br J Pharmacol,?994, 113(2), 527-535.
分子式 C18H24N4O.HCl |
分子量 348.87 |
CAS号 107007-99-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 1 mg/mL |
Water 70 mg/mL |
Ethanol 1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00873197 | Healthy | Drug: granisetron | Prostrakan Pharmaceuticals | Phase 1 | 2009-04-01 | 2009-05-01 |
NCT00868764 | Pharmacokinetics | Drug: granisetron | Prostrakan Pharmaceuticals | Phase 1 | 2009-04-01 | 2009-10-05 |
NCT02457195 | Postoperative Nausea and Vomiting | Drug: granisetron | Milton S. Hershey Medical Center | Phase 2 | 2016-02-01 | 2016-09-12 |
NCT00450853 | Vomiting | Drug: granisetron | Clinica Universidad de Navarra, Universidad de Navarra | Phase 2 | 2005-04-01 | 2015-01-26 |
NCT01073696 | Healthy | Drug: granisetron IV|Drug: granisetron patch | Prostrakan Pharmaceuticals | Phase 1 | 2010-03-01 | 2010-09-24 |
NCT00954291 | Cancer|Vomiting | Taipei Medical University WanFang Hospital | 2009-07-01 | 2010-09-03 | ||
NCT02230371 | Myofascial Pain|Temporomandibular Disorders | Drug: Granisetron|Drug: Control (placebo) | Karolinska Institutet|Folktandvrden Stockholms ln AB | Phase 4 | 2007-03-01 | 2015-09-03 |
NCT01352130 | Prolonged QTc Interval | Drug: Ondansetron|Drug: Granisetron | Tata Memorial Hospital | Phase 4 | 2007-03-01 | 2011-05-10 |
NCT00890565 | Healthy | Drug: granisetron | Prostrakan Pharmaceuticals | Phase 1 | 2009-05-01 | 2010-09-24 |
NCT03091881 | Spinal-induced Hypotension | Drug: Granisetron | Suez Canal University | Phase 4 | 2017-05-01 | 2017-03-21 |
NCT01952886 | Malignant Glioma | Drug: Granisetron|Drug: Ondansetron | Duke University|Prostrakan Pharmaceuticals | Phase 2 | null | 2014-09-19 |
NCT01989221 | Gastroparesis | Drug: Sancuso | Temple University | Phase 3 | 2012-11-01 | 2015-05-11 |
NCT00834522 | Healthy | Drug: Granisetron hydrochloride 1 mg tablets|Drug: Kytril 1 mg tablets | Teva Pharmaceuticals USA | Phase 1 | 2005-07-01 | 2009-09-01 |
NCT00231478 | Post-Operative Nausea and Vomiting | Drug: granisetron|Drug: granisetron | Hoffmann-La Roche | Phase 4 | 2007-04-01 | 2011-05-16 |
NCT00834717 | Healthy | Drug: Granisetron hydrochloride 1 mg tablets|Drug: Kytril 1 mg tablets | Teva Pharmaceuticals USA | Phase 1 | 2005-09-01 | 2009-09-01 |
NCT01662687 | Chemotherapy-induced Acute or Delayed Nausea and Vomiting (CINV) | Drug: Sancuso patch|Drug: Kytril inj.+Kytril tab. | LG Life Sciences | Phase 4 | 2012-02-01 | 2012-08-15 |
NCT01649258 | Breast Cancer|Nausea|Vomiting | Drug: granisetron transdermal system|Drug: fosaprepitant dimeglumine|Other: laboratory biomarker analysis | University of Southern California|National Cancer Institute (NCI) | 2012-09-01 | 2015-06-22 | |
NCT01596400 | Chemotherapy Induced Nausea and Vomiting | Drug: granisetron transdermal system|Drug: Granisetron IV | Kyowa Kirin Pharmaceutical Development Ltd | Phase 1 | 2012-05-01 | 2017-03-01 |
NCT01536392 | Cancer of the Cervix | Drug: Granisetron|Drug: Ondansetron|Behavioral: Questionnaires|Behavioral: Study Drug Diary | M.D. Anderson Cancer Center|Sancuso | Phase 3 | 2012-03-01 | 2016-06-22 |
NCT01183481 | Nausea|Vomiting | Drug: Aprepitant|Radiation: Palliative radiation therapy|Drug: Granisetron | Sunnybrook Health Sciences Centre|Merck Frosst Canada Ltd. | Phase 2 | 2011-01-01 | 2014-11-17 |
NCT01596426 | Chemotherapy Induced Nausea and Vomiting | Drug: Sancuso|Drug: IV granisetron | Kyowa Kirin Pharmaceutical Development Ltd | Phase 1 | 2018-07-01 | 2017-03-01 |
NCT01659775 | Chemotherapy-induced Acute or Delayed Nausea and Vomiting (CINV) | Drug: Sancuso patch|Drug: Zofran inj.+Zofran tab. | LG Life Sciences | Phase 4 | 2011-08-01 | 2013-07-23 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们