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Granisetron HCl

盐酸格拉司琼

Granisetron Hydrochloride是5-HT3受体拮抗剂,可作为化疗后止吐剂。

目录号
EY1310
EY1310
EY1310
纯度
99.79%
99.79%
99.79%
规格
25 mg
50 mg
100 mg
原价
470
720
1100
售价
470
720
1100
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Granisetron is a serotonin 5-HT3 receptor antagonist,used to treat chemotherapy-induced nausea and vomiting.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] de Lorenzi FG, et al. Br J Pharmacol,?994, 113(2), 527-535.

    分子式
    C18H24N4O.HCl
    分子量
    348.87
    CAS号
    107007-99-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    1 mg/mL
    Water
    70 mg/mL
    Ethanol
    1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00873197 Healthy Drug: granisetron Prostrakan Pharmaceuticals Phase 1 2009-04-01 2009-05-01
    NCT00868764 Pharmacokinetics Drug: granisetron Prostrakan Pharmaceuticals Phase 1 2009-04-01 2009-10-05
    NCT02457195 Postoperative Nausea and Vomiting Drug: granisetron Milton S. Hershey Medical Center Phase 2 2016-02-01 2016-09-12
    NCT00450853 Vomiting Drug: granisetron Clinica Universidad de Navarra, Universidad de Navarra Phase 2 2005-04-01 2015-01-26
    NCT01073696 Healthy Drug: granisetron IV|Drug: granisetron patch Prostrakan Pharmaceuticals Phase 1 2010-03-01 2010-09-24
    NCT00954291 Cancer|Vomiting Taipei Medical University WanFang Hospital 2009-07-01 2010-09-03
    NCT02230371 Myofascial Pain|Temporomandibular Disorders Drug: Granisetron|Drug: Control (placebo) Karolinska Institutet|Folktandvrden Stockholms ln AB Phase 4 2007-03-01 2015-09-03
    NCT01352130 Prolonged QTc Interval Drug: Ondansetron|Drug: Granisetron Tata Memorial Hospital Phase 4 2007-03-01 2011-05-10
    NCT00890565 Healthy Drug: granisetron Prostrakan Pharmaceuticals Phase 1 2009-05-01 2010-09-24
    NCT03091881 Spinal-induced Hypotension Drug: Granisetron Suez Canal University Phase 4 2017-05-01 2017-03-21
    NCT01952886 Malignant Glioma Drug: Granisetron|Drug: Ondansetron Duke University|Prostrakan Pharmaceuticals Phase 2 null 2014-09-19
    NCT01989221 Gastroparesis Drug: Sancuso Temple University Phase 3 2012-11-01 2015-05-11
    NCT00834522 Healthy Drug: Granisetron hydrochloride 1 mg tablets|Drug: Kytril 1 mg tablets Teva Pharmaceuticals USA Phase 1 2005-07-01 2009-09-01
    NCT00231478 Post-Operative Nausea and Vomiting Drug: granisetron|Drug: granisetron Hoffmann-La Roche Phase 4 2007-04-01 2011-05-16
    NCT00834717 Healthy Drug: Granisetron hydrochloride 1 mg tablets|Drug: Kytril 1 mg tablets Teva Pharmaceuticals USA Phase 1 2005-09-01 2009-09-01
    NCT01662687 Chemotherapy-induced Acute or Delayed Nausea and Vomiting (CINV) Drug: Sancuso patch|Drug: Kytril inj.+Kytril tab. LG Life Sciences Phase 4 2012-02-01 2012-08-15
    NCT01649258 Breast Cancer|Nausea|Vomiting Drug: granisetron transdermal system|Drug: fosaprepitant dimeglumine|Other: laboratory biomarker analysis University of Southern California|National Cancer Institute (NCI) 2012-09-01 2015-06-22
    NCT01596400 Chemotherapy Induced Nausea and Vomiting Drug: granisetron transdermal system|Drug: Granisetron IV Kyowa Kirin Pharmaceutical Development Ltd Phase 1 2012-05-01 2017-03-01
    NCT01536392 Cancer of the Cervix Drug: Granisetron|Drug: Ondansetron|Behavioral: Questionnaires|Behavioral: Study Drug Diary M.D. Anderson Cancer Center|Sancuso Phase 3 2012-03-01 2016-06-22
    NCT01183481 Nausea|Vomiting Drug: Aprepitant|Radiation: Palliative radiation therapy|Drug: Granisetron Sunnybrook Health Sciences Centre|Merck Frosst Canada Ltd. Phase 2 2011-01-01 2014-11-17
    NCT01596426 Chemotherapy Induced Nausea and Vomiting Drug: Sancuso|Drug: IV granisetron Kyowa Kirin Pharmaceutical Development Ltd Phase 1 2018-07-01 2017-03-01
    NCT01659775 Chemotherapy-induced Acute or Delayed Nausea and Vomiting (CINV) Drug: Sancuso patch|Drug: Zofran inj.+Zofran tab. LG Life Sciences Phase 4 2011-08-01 2013-07-23

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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