Amfebutamone HCl

盐酸安非他酮,Bupropion HCl

Amfebutamone HCl是一种选择性去甲肾上腺素-多巴胺再摄取的抑制剂,IC50分别为6.5和3.4μM。

目录号
EY1308
EY1308
纯度
99.36%
99.36%
规格
50 mg
100 mg
原价
490
890
售价
490
890
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Henshall, D.C., et al. 2009. Neuropsychiatr Dis Treat. 5: 189-206. PMID: 19557114
    [2] Silverstone, P.H., et al. 2008. Ann Gen Psychiatry. 7: 11. PMID: 18706108
    [3] Cooper, B.R., et al. 1980. J. Pharmacol. Exp. Ther. 215: 127-134. PMID: 6778989
    [4] Papakostas, G.I., et al. 2008. J Clin Psychiatry. 69: 1287-1292. PMID: 18605812

    分子式
    C13H19Cl2NO
    分子量
    276.2
    CAS号
    31677-93-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    15 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02616315 Weight Regain Post Bariatric Surgery Drug: Naltrexone HCl/Bupropion HCl Placebo|Drug: Naltrexone HCl/Bupropion HCl Takeda Phase 4 2016-02-01 2016-04-07
    NCT01015170 Cigarette Smoking|Nicotine Addiction|Smoking Cessation Drug: bupropion HCl Centre for Addiction and Mental Health|Ontario Ministry of Health and Long Term Care Phase 4 2009-10-01 2017-02-07
    NCT02638129 Obesity|Cardiovascular Diseases Drug: Naltrexone HCl/Bupropion HCl ER|Drug: Placebo Orexigen Therapeutics, Inc Phase 4 2016-01-01 2017-02-21
    NCT02698553 Depressive Disorder, Major Drug: Bupropion HCl XL tablet 150mg|Drug: Bupropion HCl XL tablet 300mg GlaxoSmithKline Phase 1 2016-05-01 2016-07-15
    NCT01111149 Schizophrenia|Smoking Cessation Other: Sugar Pill|Drug: Varenicline|Drug: Bupropion HCl University of Minnesota - Clinical and Translational Science Institute|National Institutes of Health (NIH)|National Institute on Drug Abuse (NIDA) Phase 2 2009-12-01 2014-07-08
    NCT01046214 Depressive Disorder Drug: Bupropion HCl|Drug: Bupropion HCl Teva Pharmaceuticals USA Phase 1 2010-01-01 2015-11-19
    NCT00883155 Healthy Drug: Bupropion HCl 100 mg Tablets (Invamed Inc.)|Drug: Wellbutrin 100 mg Tablets (Glaxo Wellcome) Sandoz Phase 1 1998-10-01 2009-04-16
    NCT00689611 Acute Coronary Syndrome|Myocardial Infarction|Smoking Drug: Bupropion HCl ER|Drug: Placebo Mark Eisenberg|Canadian Institutes of Health Research (CIHR)|Heart and Stroke Foundation of Canada|McGill University Phase 3 2005-12-01 2015-04-10
    NCT02735603 Heart Repolarization Drug: Naltrexone HCl/bupropion HCl|Other: Placebo|Drug: Moxifloxacin Orexigen Therapeutics, Inc Phase 1 2016-04-01 2016-10-31
    NCT00865410 Healthy Drug: Abrika Bupropion 150 mg Extended-Released Tablet|Drug: Wellbutrin SR 150 mg Extended-Release Tablet, single dose Actavis Inc. Phase 1 2004-08-01 2010-08-13
    NCT00064467 Epilepsy|Major Depressive Disorder (MDD) Drug: Extended-release bupropion (HCl) GlaxoSmithKline Phase 3 2003-06-01 2017-01-18
    NCT02078180 Depression Drug: generic bupropion University of Michigan Phase 4 2014-04-01 2016-05-13
    NCT00861939 Depression Drug: Bupropion HCI 300 mg Extended-Release Tablets EON|Drug: WELLBUTRIN XL 300 mg Extended-Release Tablets GlaxoSmithKline Sandoz Phase 1 2004-03-01 2009-03-13
    NCT00248118 Tobacco Dependence Drug: Bupropion National Institute on Drug Abuse (NIDA)|National Institutes of Health Clinical Center (CC) Phase 2|Phase 3 2005-01-01 2016-09-22
    NCT01648283 Healthy Volunteers Drug: racemic methadone HC1|Drug: Oral deuterated racemic methadone HCl, Washington University School of Medicine 2012-05-01 2016-06-16
    NCT00322205 Smoking Cessation Drug: zyban National Institutes of Health (NIH)|National Institute on Drug Abuse (NIDA) Phase 4 1999-06-01 2017-01-10
    NCT01526005 Cigarette Smoking Drug: Transdermal Nicotine Patch|Drug: Transdermal Placebo Patch Brentwood Biomedical Research Institute Phase 3 2012-03-01 2015-01-26

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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