Atropine sulfate monohydrate是毒蕈碱乙酰胆碱受体拮抗剂。
Atropine is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Schwahn HN, et al. Vis Neurosci,?000, 17(2), 165-176.
分子式 C34H50N2O11S |
分子量 694.83 |
CAS号 5908-99-6 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 200 mM |
Water 200 mM |
Ethanol 200 mM |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01819064 | Bradycardia|Arrhythmias | Drug: Atropine|Drug: Atropine | State University of New York at Buffalo | 2013-02-01 | 2013-08-01 | |
NCT02186132 | Bradycardia|Neostigmine Adverse Reaction|Adverse Reaction to Belladonna or Atropine | Drug: Atropine 0.6 mg|Drug: Atropine 1.2 mg | Mahidol University | Phase 4 | 2012-03-01 | 2014-07-07 |
NCT00834470 | Conscious Sedation | Drug: Atropine | Seoul National University Hospital | Phase 4 | 2008-08-01 | 2012-08-03 |
NCT02870478 | Myopia | Drug: Atropine | University of California, Berkeley | Phase 3 | 2016-07-01 | 2016-08-16 |
NCT00947596 | Organophosphorus Poisoning | Drug: atropine sulfate|Drug: atropine sulfate | MicroDose Defense Products L.L.C.|University of Pittsburgh|U.S. Army Space and Missile Defense Command | Phase 1 | 2009-08-01 | 2010-08-10 |
NCT02055378 | Myopia | Drug: Atropine|Device: auricular acupoint stimulation | Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation | 2011-01-01 | 2014-02-03 | |
NCT02130167 | Myopia Progression | Drug: Atropine | Chang Gung Memorial Hospital | 2012-08-01 | 2014-05-01 | |
NCT01595399 | Bradycardia|Hypoxemia | Drug: atropine|Drug: Placebo | University of Manitoba | Phase 4 | 2012-04-01 | 2013-09-23 |
NCT00315302 | Amblyopia | Drug: Atropine|Device: Plano Lens | Jaeb Center for Health Research|National Eye Institute (NEI) | Phase 3 | 2005-02-01 | 2016-07-15 |
NCT02704923 | Ventilator-Associated Pneumonia | Drug: Atropine|Drug: Placebo | Universidade de Passo Fundo | Phase 2 | 2015-02-01 | 2016-03-09 |
NCT00623207 | Chest Pain | Drug: Atropine | HaEmek Medical Center, Israel | Phase 3 | 2007-12-01 | 2015-07-24 |
NCT00944710 | Amblyopia | Drug: Atropine|Device: Plano lens|Drug: Atropine | Jaeb Center for Health Research|National Eye Institute (NEI) | Phase 3 | 2009-08-01 | 2016-07-07 |
NCT00575523 | Arrhythmia|Respiratory Arrest | Drug: Atropine|Drug: Placebo | Medical University of Vienna | Phase 4 | 2003-10-01 | 2008-01-23 |
NCT01464489 | Intubation; Difficult | Drug: Atropine|Drug: Normal saline | Gachon University Gil Medical Center | 2011-05-01 | 2011-11-01 | |
NCT02955927 | Myopia | Drug: 0.01% atropine eye drops|Device: ortho-k | The Hong Kong Polytechnic University|The University of Hong Kong | 2016-11-01 | 2016-11-03 | |
NCT00315328 | Amblyopia | Drug: Atropine|Device: Patching|Procedure: Near activities | Jaeb Center for Health Research|National Eye Institute (NEI) | Phase 3 | 2005-08-01 | 2016-05-19 |
NCT02228473 | Catheter Site Discomfort|Complications|Anesthesia|Urinary Bladder Neoplasms | Drug: Glycopyrrolate|Drug: Atropine | Seoul National University Hospital | 2014-09-01 | 2014-10-27 | |
NCT01191398 | Sialorrhea | Drug: Atropine (0.01mg/kg)|Drug: Glycopyrrolate (0.01mg/kg)|Drug: Normal saline 0.9% | Craig J. Huang|University of Texas Southwestern Medical Center | 2010-06-01 | 2014-03-20 | |
NCT01871922 | Anesthesia-induced Negative Hemodynamic Effects | Drug: Placebo|Drug: Atropine | University Medical Center Groningen | 2012-10-01 | 2014-01-30 | |
NCT00921102 | Cesarean Section|Anesthesia,Spinal|Postoperative Nausea and Vomiting | Drug: Bupivacaine|Drug: Morphine|Drug: Isotonic saline solution|Drug: Atropine | University of Parma | Phase 4 | 2007-05-01 | 2009-06-15 |
NCT00815048 | Endotracheal Intubation | Drug: Atropine/Remifentanil|Drug: Fentanyl/Atropine/Succinylcholine | King Saud University|McMaster University | Phase 4 | 2006-01-01 | 2008-12-26 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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