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Fidaxomicin

非达霉素,OPT-80,PAR-101,Dificid,Dificlir,OPT80,OPT 80,PAR101,Clostomicin B1,Tiacumicin B

Fidaxomicin是选择性的梭状芽孢杆菌抗生素。

目录号
EY1304
EY1304
EY1304
EY1304
纯度
99.67%
99.67%
99.67%
99.67%
规格
1 mg
5 mg
10 mg
50 mg
原价
220
485
625.00
718.00
售价
220
485
628.00
718.00
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Venugopal AA, et al. Clin Infect Dis, 2012, 54(4), 568-574.

    分子式
    C52H74Cl2O18
    分子量
    1058.04
    CAS号
    873857-62-6
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mM
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02395848 Clostridium Difficile Infection Drug: Fidaxomicin McMaster University Phase 3 2015-07-01 2016-04-12
    NCT01552668 Clostridium Difficile Infection Drug: Fidaxomicin|Drug: Placebo Washington University School of Medicine|Centers for Disease Control and Prevention Phase 4 2012-09-01 2014-05-27
    NCT02214771 Clostridium Difficile Infection Drug: Fidaxomicin|Drug: Treatment for CDI other than fidaxomicin Type Astellas Pharma S.A.S.|Astellas Pharma Inc 2014-09-01 2016-09-14
    NCT02083627 Drug-Drug Interaction (DDI)|Intestinal Absorption|Healthy Subjects|Pharmacokinetics of Rosuvastatin|Pharmacokinetics of Fidaxomicin Drug: rosuvastatin|Drug: fidaxomicin Astellas Pharma Europe B.V.|Cubist Pharmaceuticals LLC|Astellas Pharma Inc Phase 1 2013-02-01 2014-05-19
    NCT01813448 Pharmacokinetics of Fidaxomicin|Healthy Subjects Drug: Fidaxomicin|Drug: Placebo Astellas Pharma Global Development, Inc.|Cubist Pharmaceuticals LLC|Astellas Pharma Inc Phase 1 2013-02-01 2014-05-19
    NCT01591863 Clostridium Difficile-associated Diarrhea Drug: fidaxomicin Optimer Pharmaceuticals LLC Phase 2 2012-06-01 2016-04-06
    NCT01818141 Clostridium Difficile Infection Drug: Vancomycin|Drug: Fidaxomicin Hartford Hospital|Optimer Pharmaceuticals LLC Phase 4 2012-08-01 2013-03-21
    NCT02692651 Clostridium Difficile Infection (CDI) Drug: Fidaxomicin|Drug: Vancomycin University of Michigan|Merck Sharp & Dohme Corp. Phase 4 2017-04-01 2017-03-21
    NCT02437591 Inflammatory Bowel Disease (IBD)|Clostridium Difficile Infection (CDI) Drug: fidaxomicin Astellas Pharma Europe Ltd.|Merck Sharp & Dohme Corp.|Astellas Pharma Inc Phase 4 2015-06-01 2017-03-17
    NCT01691248 Clostridium Difficile-Associated Diarrhea (CDAD) Drug: fidaxomicin|Drug: Placebo Optimer Pharmaceuticals LLC Phase 3 2012-10-01 2016-03-11
    NCT02461901 Clostridium Difficile Infection Other: Environmental sampling|Other: Skin swab sampling|Other: Fecal sampling Professor Mark Wilcox|Astellas Pharma Europe Ltd.|The Leeds Teaching Hospitals NHS Trust|St George's Healthcare NHS Trust|University of Leeds 2015-01-01 2016-05-13
    NCT02218372 Clostridium Difficile-associated Diarrhea (CDAD) Drug: Fidaxomicin|Drug: Vancomycin Astellas Pharma Europe B.V.|Merck Sharp & Dohme Corp.|Astellas Pharma Inc Phase 3 2014-10-01 2017-02-01
    NCT00314951 Clostridium Infections|Diarrhea Drug: Fidaxomicin|Drug: Vancomycin|Drug: Matching Placebo to Fidaxomicin Optimer Pharmaceuticals LLC Phase 3 2006-05-01 2016-06-07
    NCT02464306 Clostridium Difficile Infection|Solid Organ Transplant Drug: fidaxomicin University of Colorado, Denver Phase 4 2016-12-01 2016-06-15
    NCT02355938 Clostridium Difficile|Spinal Cord Injury Drug: Fidaxomicin 200 mg|Drug: Placebo|Drug: Vancomycin Baylor College of Medicine|Cubist Pharmaceuticals LLC Phase 4 2014-02-01 2016-10-12
    NCT02254967 Clostridium Difficile Drug: Fidaxomicin|Drug: Vancomycin Astellas Pharma Europe Ltd.|Merck Sharp & Dohme Corp.|Astellas Pharma Inc Phase 4 2014-10-01 2016-11-01
    NCT01775397 Clostridium Difficile Drug: Fidaxomicin|Drug: Vancomycin|Drug: Placebo Astellas Pharma Europe Ltd.|Cubist Pharmaceuticals LLC|Astellas Pharma Inc Phase 4 2012-11-01 2014-06-02
    NCT02784002 Clostridium Difficile Infection Drug: Ridinilazole|Drug: Fidaxomicin Summit Therapeutics Phase 2 2014-12-01 2016-08-02
    NCT01533844 Clostridium Difficile Astellas Pharma Europe B.V.|Astellas Pharma Inc 2012-03-01 2015-03-03
    NCT02057198 C. Difficile|Diarrhea|Enterocolitis Drug: Fidaxomicin|Drug: Metronidazole|Drug: Vancomycin Duke University Phase 4 2014-02-01 2016-08-31

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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