Fidaxomicin是选择性的梭状芽孢杆菌抗生素。
Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Venugopal AA, et al. Clin Infect Dis, 2012, 54(4), 568-574.
分子式 C52H74Cl2O18 |
分子量 1058.04 |
CAS号 873857-62-6 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mM |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02395848 | Clostridium Difficile Infection | Drug: Fidaxomicin | McMaster University | Phase 3 | 2015-07-01 | 2016-04-12 |
NCT01552668 | Clostridium Difficile Infection | Drug: Fidaxomicin|Drug: Placebo | Washington University School of Medicine|Centers for Disease Control and Prevention | Phase 4 | 2012-09-01 | 2014-05-27 |
NCT02214771 | Clostridium Difficile Infection | Drug: Fidaxomicin|Drug: Treatment for CDI other than fidaxomicin Type | Astellas Pharma S.A.S.|Astellas Pharma Inc | 2014-09-01 | 2016-09-14 | |
NCT02083627 | Drug-Drug Interaction (DDI)|Intestinal Absorption|Healthy Subjects|Pharmacokinetics of Rosuvastatin|Pharmacokinetics of Fidaxomicin | Drug: rosuvastatin|Drug: fidaxomicin | Astellas Pharma Europe B.V.|Cubist Pharmaceuticals LLC|Astellas Pharma Inc | Phase 1 | 2013-02-01 | 2014-05-19 |
NCT01813448 | Pharmacokinetics of Fidaxomicin|Healthy Subjects | Drug: Fidaxomicin|Drug: Placebo | Astellas Pharma Global Development, Inc.|Cubist Pharmaceuticals LLC|Astellas Pharma Inc | Phase 1 | 2013-02-01 | 2014-05-19 |
NCT01591863 | Clostridium Difficile-associated Diarrhea | Drug: fidaxomicin | Optimer Pharmaceuticals LLC | Phase 2 | 2012-06-01 | 2016-04-06 |
NCT01818141 | Clostridium Difficile Infection | Drug: Vancomycin|Drug: Fidaxomicin | Hartford Hospital|Optimer Pharmaceuticals LLC | Phase 4 | 2012-08-01 | 2013-03-21 |
NCT02692651 | Clostridium Difficile Infection (CDI) | Drug: Fidaxomicin|Drug: Vancomycin | University of Michigan|Merck Sharp & Dohme Corp. | Phase 4 | 2017-04-01 | 2017-03-21 |
NCT02437591 | Inflammatory Bowel Disease (IBD)|Clostridium Difficile Infection (CDI) | Drug: fidaxomicin | Astellas Pharma Europe Ltd.|Merck Sharp & Dohme Corp.|Astellas Pharma Inc | Phase 4 | 2015-06-01 | 2017-03-17 |
NCT01691248 | Clostridium Difficile-Associated Diarrhea (CDAD) | Drug: fidaxomicin|Drug: Placebo | Optimer Pharmaceuticals LLC | Phase 3 | 2012-10-01 | 2016-03-11 |
NCT02461901 | Clostridium Difficile Infection | Other: Environmental sampling|Other: Skin swab sampling|Other: Fecal sampling | Professor Mark Wilcox|Astellas Pharma Europe Ltd.|The Leeds Teaching Hospitals NHS Trust|St George's Healthcare NHS Trust|University of Leeds | 2015-01-01 | 2016-05-13 | |
NCT02218372 | Clostridium Difficile-associated Diarrhea (CDAD) | Drug: Fidaxomicin|Drug: Vancomycin | Astellas Pharma Europe B.V.|Merck Sharp & Dohme Corp.|Astellas Pharma Inc | Phase 3 | 2014-10-01 | 2017-02-01 |
NCT00314951 | Clostridium Infections|Diarrhea | Drug: Fidaxomicin|Drug: Vancomycin|Drug: Matching Placebo to Fidaxomicin | Optimer Pharmaceuticals LLC | Phase 3 | 2006-05-01 | 2016-06-07 |
NCT02464306 | Clostridium Difficile Infection|Solid Organ Transplant | Drug: fidaxomicin | University of Colorado, Denver | Phase 4 | 2016-12-01 | 2016-06-15 |
NCT02355938 | Clostridium Difficile|Spinal Cord Injury | Drug: Fidaxomicin 200 mg|Drug: Placebo|Drug: Vancomycin | Baylor College of Medicine|Cubist Pharmaceuticals LLC | Phase 4 | 2014-02-01 | 2016-10-12 |
NCT02254967 | Clostridium Difficile | Drug: Fidaxomicin|Drug: Vancomycin | Astellas Pharma Europe Ltd.|Merck Sharp & Dohme Corp.|Astellas Pharma Inc | Phase 4 | 2014-10-01 | 2016-11-01 |
NCT01775397 | Clostridium Difficile | Drug: Fidaxomicin|Drug: Vancomycin|Drug: Placebo | Astellas Pharma Europe Ltd.|Cubist Pharmaceuticals LLC|Astellas Pharma Inc | Phase 4 | 2012-11-01 | 2014-06-02 |
NCT02784002 | Clostridium Difficile Infection | Drug: Ridinilazole|Drug: Fidaxomicin | Summit Therapeutics | Phase 2 | 2014-12-01 | 2016-08-02 |
NCT01533844 | Clostridium Difficile | Astellas Pharma Europe B.V.|Astellas Pharma Inc | 2012-03-01 | 2015-03-03 | ||
NCT02057198 | C. Difficile|Diarrhea|Enterocolitis | Drug: Fidaxomicin|Drug: Metronidazole|Drug: Vancomycin | Duke University | Phase 4 | 2014-02-01 | 2016-08-31 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们