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Spironolactone

螺内酯,SC9420,Aldactone,SC 9420,SC-9420,

Spironolactone是雄激素受体拮抗剂, IC50为77 nM.

目录号
EY1303
EY1303
EY1303
纯度
99.13%
99.13%
99.13%
规格
50 mg
100 mg
1 g
原价
270
442.00
620
售价
270
442.00
620
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    0-1毫克/天腹腔注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Fagart J, et al. J Biol Chem, 2010, 285(39), 29932-29940.

    分子式
    C24H32O4S
    分子量
    416.57
    CAS号
    52-01-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    83 mg/mL
    Water
    <1 mg/mL
    Ethanol
    20 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02417896 Acute Kidney Injuries|Kidney Injuries, Acute|Kidney Injury, Acute|Acute Renal Injury|Acute Renal Injuries Drug: Spironolactone Instituto Nacional de Cardiologia Ignacio Chavez|Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran 2013-04-01 2015-04-15
    NCT01468571 Pulmonary Hypertension Drug: Spironolactone|Drug: Placebo Baylor College of Medicine|National Heart, Lung, and Blood Institute (NHLBI) Phase 4 2011-07-01 2015-05-06
    NCT01422759 Obesity|Hyperandrogenemia|Polycystic Ovary Syndrome Drug: Spironolactone University of Virginia 2016-11-01 2016-12-16
    NCT02053974 Anthracycline Induced Cardiotoxicity Drug: Spironolactone|Other: Placebo TC Erciyes University Phase 4 2011-09-01 2014-02-01
    NCT02429388 Heart Failure Drug: Spironolactone The University of Texas Health Science Center at San Antonio Phase 4 2014-05-01 2016-04-19
    NCT01128101 Renal Failure Drug: Spironolactone UPECLIN HC FM Botucatu Unesp Phase 4 2011-03-01 2011-09-02
    NCT00689598 Atrial Fibrillation Drug: Spironolactone|Drug: Placebo Taichung Veterans General Hospital 2008-03-01 2008-06-04
    NCT02046668 Osteoarthritis, Knee Drug: spironolactone University of Dundee|Arthritis Research UK Phase 4 2013-11-01 2014-01-28
    NCT02253394 Pulmonary Arterial Hypertension Drug: Ambrisentan plus Spironolactone|Drug: Ambrisentan plus Placebo Brigham and Women's Hospital|Gilead Sciences Phase 4 2015-09-01 2016-03-01
    NCT01526616 Polycystic Ovary Syndrome Drug: Metformin|Drug: Metformin plus Spironolactone University Magna Graecia 2010-05-01 2012-02-03
    NCT02531412 Critically Ill|Cancer Drug: Spironolactone|Drug: Placebo Instituto Nacional de Cancerologia de Mexico Phase 2|Phase 3 2015-10-01 2017-01-02
    NCT02673463 Atrial Fibrillation Drug: Spironolactone|Drug: Placebo University of Birmingham Phase 4 2015-01-01 2016-10-24
    NCT02883400 Transplant, Liver Drug: Spironolactone Carolinas Healthcare System Phase 4 2014-12-01 2016-08-25
    NCT01721655 Chronic Lung Disease|Bronchopulmonary Dysplasia Drug: Spironolactone|Drug: Placebo West Virginia University Healthcare Phase 2|Phase 3 2012-10-01 2016-11-28
    NCT00188045 Alcoholic Cirrhosis Drug: Propranolol - Spironolactone University Hospital, Angers Phase 4 1995-04-01 2005-12-28
    NCT00709137 Hypertension Drug: spironolactone|Drug: amiloride VA Salt Lake City Health Care System 2008-10-01 2014-05-27
    NCT02948998 Hypertrophic Cardiomyopathy|Fibrosis Drug: Spironolactone Xinhua Hospital, Shanghai Jiao Tong University School of Medicine|Ruijin Hospital|RenJi Hospital|Shanghai Jiao Tong University Affiliated Sixth People Hospital Phase 4 2016-11-01 2016-11-07
    NCT01552044 Central Serous Chorioretinitis Drug: Spironolactone|Drug: Placebo Institut National de la Sant Et de la Recherche Mdicale, France Phase 1|Phase 2 2012-01-01 2016-02-24
    NCT01021943 Kidney Transplant Drug: spironolactone|Drug: Placebo Instituto Nacional de Cardiologia Ignacio Chavez Phase 2 2009-11-01 2014-07-23
    NCT00524615 Hypertension Drug: spironolactone Jan Vaclavk|Czech Society of Hypertension|Prostejov Hospital|Brno University Hospital|Olomouc Military Hospital|Gedeon Richter Ltd.|University Hospital Olomouc Phase 4 2007-09-01 2012-06-19

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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