Spironolactone是雄激素受体拮抗剂, IC50为77 nM.
Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.
0-1毫克/天腹腔注射
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Fagart J, et al. J Biol Chem, 2010, 285(39), 29932-29940.
分子式 C24H32O4S |
分子量 416.57 |
CAS号 52-01-7 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 83 mg/mL |
Water <1 mg/mL |
Ethanol 20 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02417896 | Acute Kidney Injuries|Kidney Injuries, Acute|Kidney Injury, Acute|Acute Renal Injury|Acute Renal Injuries | Drug: Spironolactone | Instituto Nacional de Cardiologia Ignacio Chavez|Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 2013-04-01 | 2015-04-15 | |
NCT01468571 | Pulmonary Hypertension | Drug: Spironolactone|Drug: Placebo | Baylor College of Medicine|National Heart, Lung, and Blood Institute (NHLBI) | Phase 4 | 2011-07-01 | 2015-05-06 |
NCT01422759 | Obesity|Hyperandrogenemia|Polycystic Ovary Syndrome | Drug: Spironolactone | University of Virginia | 2016-11-01 | 2016-12-16 | |
NCT02053974 | Anthracycline Induced Cardiotoxicity | Drug: Spironolactone|Other: Placebo | TC Erciyes University | Phase 4 | 2011-09-01 | 2014-02-01 |
NCT02429388 | Heart Failure | Drug: Spironolactone | The University of Texas Health Science Center at San Antonio | Phase 4 | 2014-05-01 | 2016-04-19 |
NCT01128101 | Renal Failure | Drug: Spironolactone | UPECLIN HC FM Botucatu Unesp | Phase 4 | 2011-03-01 | 2011-09-02 |
NCT00689598 | Atrial Fibrillation | Drug: Spironolactone|Drug: Placebo | Taichung Veterans General Hospital | 2008-03-01 | 2008-06-04 | |
NCT02046668 | Osteoarthritis, Knee | Drug: spironolactone | University of Dundee|Arthritis Research UK | Phase 4 | 2013-11-01 | 2014-01-28 |
NCT02253394 | Pulmonary Arterial Hypertension | Drug: Ambrisentan plus Spironolactone|Drug: Ambrisentan plus Placebo | Brigham and Women's Hospital|Gilead Sciences | Phase 4 | 2015-09-01 | 2016-03-01 |
NCT01526616 | Polycystic Ovary Syndrome | Drug: Metformin|Drug: Metformin plus Spironolactone | University Magna Graecia | 2010-05-01 | 2012-02-03 | |
NCT02531412 | Critically Ill|Cancer | Drug: Spironolactone|Drug: Placebo | Instituto Nacional de Cancerologia de Mexico | Phase 2|Phase 3 | 2015-10-01 | 2017-01-02 |
NCT02673463 | Atrial Fibrillation | Drug: Spironolactone|Drug: Placebo | University of Birmingham | Phase 4 | 2015-01-01 | 2016-10-24 |
NCT02883400 | Transplant, Liver | Drug: Spironolactone | Carolinas Healthcare System | Phase 4 | 2014-12-01 | 2016-08-25 |
NCT01721655 | Chronic Lung Disease|Bronchopulmonary Dysplasia | Drug: Spironolactone|Drug: Placebo | West Virginia University Healthcare | Phase 2|Phase 3 | 2012-10-01 | 2016-11-28 |
NCT00188045 | Alcoholic Cirrhosis | Drug: Propranolol - Spironolactone | University Hospital, Angers | Phase 4 | 1995-04-01 | 2005-12-28 |
NCT00709137 | Hypertension | Drug: spironolactone|Drug: amiloride | VA Salt Lake City Health Care System | 2008-10-01 | 2014-05-27 | |
NCT02948998 | Hypertrophic Cardiomyopathy|Fibrosis | Drug: Spironolactone | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine|Ruijin Hospital|RenJi Hospital|Shanghai Jiao Tong University Affiliated Sixth People Hospital | Phase 4 | 2016-11-01 | 2016-11-07 |
NCT01552044 | Central Serous Chorioretinitis | Drug: Spironolactone|Drug: Placebo | Institut National de la Sant Et de la Recherche Mdicale, France | Phase 1|Phase 2 | 2012-01-01 | 2016-02-24 |
NCT01021943 | Kidney Transplant | Drug: spironolactone|Drug: Placebo | Instituto Nacional de Cardiologia Ignacio Chavez | Phase 2 | 2009-11-01 | 2014-07-23 |
NCT00524615 | Hypertension | Drug: spironolactone | Jan Vaclavk|Czech Society of Hypertension|Prostejov Hospital|Brno University Hospital|Olomouc Military Hospital|Gedeon Richter Ltd.|University Hospital Olomouc | Phase 4 | 2007-09-01 | 2012-06-19 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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