Zolmitriptan

佐米曲普坦

Zolmitriptan (佐米曲普坦) 是五羟色胺受体1B和1D亚型激动剂。

目录号
EY1302
EY1302
EY1302
纯度
99.36%
99.36%
99.36%
规格
50 mg
100 mg
500 mg
原价
290
380
1100
售价
290
380
1100
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Zolmitriptan is a novel and highly selective 5-HT(1B/1D) receptor agonist, used in the treatment of acute migraines.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Martin GR, et al. Br J Pharmacol,?997, 121(2), 157-164.

    分子式
    C16H21N3O2
    分子量
    287.36
    CAS号
    139264-17-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    58 mg/mL
    Water
    <1 mg/mL
    Ethanol
    58 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02609945 Migraine Drug: zolmitriptan|Drug: CVT-427 (zolmitriptan inhalation powder), Acorda Therapeutics Phase 1 2015-11-01 2016-06-03
    NCT01085123 Migraine Drug: Rapimelt|Drug: [11C]AZ10419369 AstraZeneca Phase 1 2010-05-01 2010-11-02
    NCT00637286 Migraine Drug: Zolmitriptan AstraZeneca Phase 4 2004-07-01 2009-04-03
    NCT02745392 Acute Migraine Drug: ZP-Zolmitriptan|Drug: Placebo Zosano Pharma Inc. Phase 2|Phase 3 2016-06-01 2017-01-06
    NCT00617747 Migraine Drug: Zolmitriptan|Drug: Placebo AstraZeneca Phase 3 2002-09-01 2009-04-03
    NCT00617695 Migraine Drug: Zolmitriptan|Drug: Placebo AstraZeneca Phase 3 2003-09-01 2009-04-03
    NCT01276977 Acute Migraine|Migraine Headache|Headache Disorders Drug: Zolmitriptan 5 mg Nasal Spray|Drug: Eletriptan 40 mg tablet California Medical Clinic for Headache 2008-04-01 2011-01-13
    NCT02905227 Migraine Drug: CVT-427 (zolmitriptan inhalation powder)|Other: Placebo Acorda Therapeutics Phase 1 2016-09-01 2017-01-27
    NCT01211145 Migraine Headache Drug: Placebo|Drug: Zolmitriptan|Drug: Zolmitriptan|Drug: Zolmitriptan AstraZeneca Phase 4 2010-09-01 2016-04-18
    NCT01587170 Spinal Cord Injuries|Muscle Spasticity University of Alberta 2012-01-01 2012-11-30
    NCT00442936 Migraine Drug: Telcagepant potassium 150 mg|Drug: Telcagepant potassium 300 mg|Drug: Zolmitriptan 5 mg|Drug: Placebo to telcagepant 150 mg|Drug: Placebo to tecagepant 300 mg|Drug: Placebo to zolmitriptan 5 mg|Drug: Rescue medication Merck Sharp & Dohme Corp. Phase 3 2007-02-01 2015-06-11
    NCT01435941 Migraine Disorders Drug: Non-steroidal anti-inflammatory drug (NSAID)|Drug: Triptan GlaxoSmithKline 2009-09-01 2011-09-21
    NCT02670161 Brain Tumors|Epilepsy|Migraine|Mild Cognitive Impairment|Concussion|Multiple Sclerosis|Neuropathy|Parkinson's|Restless Legs Syndrome|Stroke Drug: Listed for each disorder below, up to three drugs per disorder (too many characters to list in this field; see Intervention Description) NorthShore University HealthSystem Research Institute Phase 4 2016-05-01 2017-01-14
    NCT01381497 Migraine Disorders Drug: Combination therapy of sumatriptan and naproxen sodium (SumaRT/Nap)|Drug: Triptan monotherapy GlaxoSmithKline 2010-03-01 2012-08-23
    NCT01381523 Migraine Disorders Drug: Combination therapy with sumatriptan and naproxen sodium (SumaRT/Nap)|Drug: Single-entity oral triptans GlaxoSmithKline 2010-11-01 2013-02-21
    NCT01086358 Workplace Migraine Treatment Drug: Usual prescribed triptan|Drug: Treximet for migraine treatment The Cleveland Clinic|Pernix Theraputics LLC Phase 4 2009-09-01 2016-08-10
    NCT01332500 Migraine Disorders Drug: Sumatriptan/Naproxen combination|Drug: other oral triptans GlaxoSmithKline 2009-07-01 2011-04-19

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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