Fluconazole

氟康唑,UK 49858,UK-49858,UK49858

Fluconazole是抗真菌化合物,可用于表面和全身性的真菌感染。

目录号
EY1300
EY1300
纯度
99.56%
99.56%
规格
100 mg
500 mg
原价
620
1400
售价
620
1400
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Uppuluri P, et al. Antimicrob Agents Chemother, 2008, 52(3), 1127-1132.

    分子式
    C13H12F2N6O
    分子量
    306.27
    CAS号
    86386-73-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    61 mg/mL
    Water
    <1 mg/mL
    Ethanol
    61 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01511757 Healthy Drug: Fluconazole|Drug: Fluconazole Dr. Reddy's Laboratories Limited Phase 1 2002-06-01 2012-01-18
    NCT01511770 Healthy Drug: Fluconazole|Drug: Fluconazole Dr. Reddy's Laboratories Limited Phase 1 2002-08-01 2012-01-18
    NCT00797420 Candidiasis Drug: Fluconazole Loading Dose|Drug: Fluconazole Loading Dose & High Dose Daniel Benjamin|Pediatric Pharmacology Research Units Network|Duke University Phase 1 2008-11-01 2013-03-18
    NCT00721487 Fungal Infection by Site Drug: Fluconazole CPL Associates|Astellas Pharma US, Inc. 2008-07-01 2014-07-21
    NCT01562132 Cryptococcal Infection Disseminated Drug: Flucytosine and fluconazole|Drug: Fluconazole Yale University|National Institute of Neurological Disorders and Stroke (NINDS)|Kenya Medical Research Institute|Valeant Pharmaceuticals International, Inc.|University of Nairobi Phase 2 2013-09-01 2015-07-31
    NCT00936182 Autism Spectrum Disorder Drug: Fluconazole The Center for Autism and Related Disorders|The International Child Development Resource Center|Thoughtful House 2009-07-01 2009-07-08
    NCT01680458 Deep Mycosis Drug: Fluconazole Pfizer 2012-11-01 2015-11-04
    NCT01169402 Cardiopulmonary Arrest|Fungal Infection Drug: Fluconazole Michael Cohen-Wolkowiez|Duke University Phase 1 2010-07-01 2016-11-23
    NCT00075803 Lymphoma|Infection|Leukemia Drug: Fluconazole|Drug: Voriconazole Medical College of Wisconsin|National Heart, Lung, and Blood Institute (NHLBI)|Blood and Marrow Transplant Clinical Trials Network|National Cancer Institute (NCI)|National Marrow Donor Program Phase 3 2003-11-01 2016-08-01
    NCT01806623 Vulvovaginal Candidiasis Drug: Fluconazole Pfizer Phase 3 2013-03-01 2017-01-18
    NCT01953744 Cutaneous Leishmaniasis Drug: Fluconazole|Drug: Meglumine Antimoniate Hospital Universitrio Professor Edgard Santos|Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico|Federal University of Bahia Phase 3 2014-02-01 2015-12-01
    NCT02180100 Vulvovaginal Candidiasis Drug: Terconazole Vaginal Suppository|Drug: Fluconazole Peking University Shenzhen Hospital|Shanghai Shyndec Pharmaceutical Co.,Ltd. Phase 4 2013-08-01 2015-04-27
    NCT02180828 Candidiasis, Vulvovaginal Drug: Clotrimazole vaginal tablet|Drug: Fluconazole Peking University Shenzhen Hospital|Bayer Phase 4 2014-07-01 2016-08-08
    NCT02666716 Candidiasis Drug: fluconazole Radboud University 2015-05-01 2016-04-06
    NCT00734539 Candidiasis Drug: fluconazole|Drug: placebo Daniel Benjamin|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Thrasher Research Fund|Food and Drug Administration (FDA)|Duke University Phase 3 2008-11-01 2014-07-27
    NCT01683760 Very Low Birth Weight Infant Drug: Fluconazole Seoul National University Hospital Phase 2 2012-09-01 2014-11-17
    NCT00885703 Cryptococcal Meningitis|HIV Infections Drug: Fluconazole|Drug: Amphotericin B National Institute of Allergy and Infectious Diseases (NIAID) Phase 1|Phase 2 2010-02-01 2017-03-06
    NCT00911235 Overactive Bladder With Symptoms of Frequency, Urgency, and Urge Urinary Incontinence Drug: Fesoterodine|Drug: fesoterodine plus fluconazole Pfizer Phase 1 2009-05-01 2011-05-31
    NCT00145249 Cryptococcal Meningitis Drug: Amphotericin B|Drug: Fluconazole National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2005-05-01 2012-05-10
    NCT02663674 Coccidioidomycosis Drug: Fluconazole|Other: Placebo National Institute of Allergy and Infectious Diseases (NIAID) Phase 4 2015-12-29 2017-02-09
    NCT00841971 Mycoses|Fungemia|Central Nervous System Fungal Infections|Lung Diseases, Fungal Drug: Anidulafungin|Drug: Fluconazole University of Pittsburgh Phase 4 2010-02-01 2014-12-15

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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