Fluconazole是抗真菌化合物,可用于表面和全身性的真菌感染。
Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Uppuluri P, et al. Antimicrob Agents Chemother, 2008, 52(3), 1127-1132.
分子式 C13H12F2N6O |
分子量 306.27 |
CAS号 86386-73-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 61 mg/mL |
Water <1 mg/mL |
Ethanol 61 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01511757 | Healthy | Drug: Fluconazole|Drug: Fluconazole | Dr. Reddy's Laboratories Limited | Phase 1 | 2002-06-01 | 2012-01-18 |
NCT01511770 | Healthy | Drug: Fluconazole|Drug: Fluconazole | Dr. Reddy's Laboratories Limited | Phase 1 | 2002-08-01 | 2012-01-18 |
NCT00797420 | Candidiasis | Drug: Fluconazole Loading Dose|Drug: Fluconazole Loading Dose & High Dose | Daniel Benjamin|Pediatric Pharmacology Research Units Network|Duke University | Phase 1 | 2008-11-01 | 2013-03-18 |
NCT00721487 | Fungal Infection by Site | Drug: Fluconazole | CPL Associates|Astellas Pharma US, Inc. | 2008-07-01 | 2014-07-21 | |
NCT01562132 | Cryptococcal Infection Disseminated | Drug: Flucytosine and fluconazole|Drug: Fluconazole | Yale University|National Institute of Neurological Disorders and Stroke (NINDS)|Kenya Medical Research Institute|Valeant Pharmaceuticals International, Inc.|University of Nairobi | Phase 2 | 2013-09-01 | 2015-07-31 |
NCT00936182 | Autism Spectrum Disorder | Drug: Fluconazole | The Center for Autism and Related Disorders|The International Child Development Resource Center|Thoughtful House | 2009-07-01 | 2009-07-08 | |
NCT01680458 | Deep Mycosis | Drug: Fluconazole | Pfizer | 2012-11-01 | 2015-11-04 | |
NCT01169402 | Cardiopulmonary Arrest|Fungal Infection | Drug: Fluconazole | Michael Cohen-Wolkowiez|Duke University | Phase 1 | 2010-07-01 | 2016-11-23 |
NCT00075803 | Lymphoma|Infection|Leukemia | Drug: Fluconazole|Drug: Voriconazole | Medical College of Wisconsin|National Heart, Lung, and Blood Institute (NHLBI)|Blood and Marrow Transplant Clinical Trials Network|National Cancer Institute (NCI)|National Marrow Donor Program | Phase 3 | 2003-11-01 | 2016-08-01 |
NCT01806623 | Vulvovaginal Candidiasis | Drug: Fluconazole | Pfizer | Phase 3 | 2013-03-01 | 2017-01-18 |
NCT01953744 | Cutaneous Leishmaniasis | Drug: Fluconazole|Drug: Meglumine Antimoniate | Hospital Universitrio Professor Edgard Santos|Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico|Federal University of Bahia | Phase 3 | 2014-02-01 | 2015-12-01 |
NCT02180100 | Vulvovaginal Candidiasis | Drug: Terconazole Vaginal Suppository|Drug: Fluconazole | Peking University Shenzhen Hospital|Shanghai Shyndec Pharmaceutical Co.,Ltd. | Phase 4 | 2013-08-01 | 2015-04-27 |
NCT02180828 | Candidiasis, Vulvovaginal | Drug: Clotrimazole vaginal tablet|Drug: Fluconazole | Peking University Shenzhen Hospital|Bayer | Phase 4 | 2014-07-01 | 2016-08-08 |
NCT02666716 | Candidiasis | Drug: fluconazole | Radboud University | 2015-05-01 | 2016-04-06 | |
NCT00734539 | Candidiasis | Drug: fluconazole|Drug: placebo | Daniel Benjamin|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Thrasher Research Fund|Food and Drug Administration (FDA)|Duke University | Phase 3 | 2008-11-01 | 2014-07-27 |
NCT01683760 | Very Low Birth Weight Infant | Drug: Fluconazole | Seoul National University Hospital | Phase 2 | 2012-09-01 | 2014-11-17 |
NCT00885703 | Cryptococcal Meningitis|HIV Infections | Drug: Fluconazole|Drug: Amphotericin B | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1|Phase 2 | 2010-02-01 | 2017-03-06 |
NCT00911235 | Overactive Bladder With Symptoms of Frequency, Urgency, and Urge Urinary Incontinence | Drug: Fesoterodine|Drug: fesoterodine plus fluconazole | Pfizer | Phase 1 | 2009-05-01 | 2011-05-31 |
NCT00145249 | Cryptococcal Meningitis | Drug: Amphotericin B|Drug: Fluconazole | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 | 2005-05-01 | 2012-05-10 |
NCT02663674 | Coccidioidomycosis | Drug: Fluconazole|Other: Placebo | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 4 | 2015-12-29 | 2017-02-09 |
NCT00841971 | Mycoses|Fungemia|Central Nervous System Fungal Infections|Lung Diseases, Fungal | Drug: Anidulafungin|Drug: Fluconazole | University of Pittsburgh | Phase 4 | 2010-02-01 | 2014-12-15 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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