Rosuvastatin Calcium是一种竞争性HMG-CoA还原酶抑制剂, with IC50为11 nM。
Rosuvastatin Calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Schneck DW, et al. Clin Pharmacol Ther, 2004, 75(5), 4554-63.
分子式 C44H54CaF2N6O12S2 |
分子量 500.57 |
CAS号 147098-20-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02569645 | Rectal Cancer | Drug: Rosuvastatin | AHS Cancer Control Alberta|Ozmosis Research Inc. | Phase 2 | 2015-11-01 | 2016-09-19 |
NCT01218347 | Organic Anion Transporting Polypeptide1B1 (OATP1B1)|Rosuvastatin | Drug: Rosuvastatin | Seoul National University Hospital | Phase 4 | 2010-10-01 | 2011-01-04 |
NCT00766025 | CYP2C19 Poor|Extensive Metabolizers | Drug: Rosuvastatin Calcium | AstraZeneca | Phase 1 | 2008-09-01 | 2009-02-27 |
NCT01524601 | Disorder Related to Renal Transplantation|Hypercholesterolemia | Drug: Rosuvastatin | University of Oslo School of Pharmacy|Oslo University Hospital | Phase 4 | 2012-02-01 | 2012-10-11 |
NCT02106767 | Healthy | Drug: Rosuvastatin|Drug: Rosuvastatin plus rifampin | University of California, San Francisco | Phase 1 | 2014-11-01 | 2015-12-01 |
NCT01466608 | Hypercholesterolemia | Drug: Rosuvastatin | Seoul National University Hospital | Phase 4 | 2011-11-01 | 2014-05-15 |
NCT01490398 | Hypertension|Cardiovascular Risk Factors | Drug: Rosuvastatin | Asan Medical Center|AstraZeneca | Phase 4 | 2011-12-01 | 2014-05-08 |
NCT02215174 | Statin Pharmacokinetics Pre and Post Gastric Bypass Surgery | Drug: Rosuvastatin | University of California, San Francisco|E-DA Hospital | Phase 1 | 2015-02-01 | 2015-04-24 |
NCT00463606 | Hypercholesterolemia|Dyslipidemia | Drug: ABT-335 and rosuvastatin calcium|Drug: ABT-335|Drug: rosuvastatin calcium | AstraZeneca | Phase 3 | 2007-04-01 | 2012-09-27 |
NCT02705547 | Friedreich Ataxia | Drug: Rosuvastatin | Children's Hospital of Philadelphia|Friedreich's Ataxia Research Alliance | Early Phase 1 | 2016-05-01 | 2017-03-15 |
NCT00986999 | HIV Infections|Cardiovascular Disease | Drug: rosuvastatin | University of Hawaii | Phase 2|Phase 3 | 2009-09-01 | 2015-01-20 |
NCT00660764 | Hypercholesterolemia|Coronary Heart Disease|Peripheral Vascular Disease|Cerebrovascular Accident|Diabetes | Drug: Rosuvastatin | AstraZeneca | 2003-05-01 | 2009-03-13 | |
NCT02284503 | Non-ST-elevation Acute Coronary Syndromes | Drug: Rosuvastatin | Shanghai Zhongshan Hospital | Phase 4 | 2014-11-01 | 2014-11-03 |
NCT00240318 | Coronary Arteriosclerosis | Drug: Rosuvastatin calcium | AstraZeneca | Phase 3 | 2002-11-01 | 2010-11-18 |
NCT01382277 | Hyperlipidemia|Coronary Artery Disease | Drug: Rosuvastatin | Peking University First Hospital | Phase 4 | 2011-03-01 | 2011-06-23 |
NCT00225589 | Hypercholesteremia | Drug: Rosuvastatin calcium | AstraZeneca | Phase 3 | 2002-08-01 | 2010-11-18 |
NCT02083627 | Drug-Drug Interaction (DDI)|Intestinal Absorption|Healthy Subjects|Pharmacokinetics of Rosuvastatin|Pharmacokinetics of Fidaxomicin | Drug: rosuvastatin|Drug: fidaxomicin | Astellas Pharma Europe B.V.|Cubist Pharmaceuticals LLC|Astellas Pharma Inc | Phase 1 | 2013-02-01 | 2014-05-19 |
NCT01863914 | End-stage Kidney Disease|Diabetes Mellitus|Arteriovenous Fistula | Drug: Rosuvastatin | National Cheng-Kung University Hospital | Phase 2 | 2012-11-01 | 2016-09-24 |
NCT00966472 | Squamous Cell Carcinoma|Non-Small Cell Lung Cancer | Drug: Erlotinib + Rosuvastatin | Ottawa Hospital Research Institute|Ozmosis Research Inc. | Phase 1 | 2009-03-01 | 2015-04-21 |
NCT00984932 | Systemic Sclerosis | Drug: Rosuvastatin | Faculty of Medicine, University of Alexandria | Phase 3 | 2008-09-01 | 2009-09-24 |
NCT03007524 | Acute Coronary Syndrome | Drug: High dose Rosuvastatin|Drug: Low dose Rosuvastatin | Nanjing First Hospital, Nanjing Medical University | Phase 4 | 2016-07-01 | 2017-02-19 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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