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Rosuvastatin Calcium

Rosuvastatin Calcium是一种竞争性HMG-CoA还原酶抑制剂, with IC50为11 nM。

目录号
EY1293
EY1293
EY1293
纯度
99.55%
99.55%
99.55%
规格
5 mg
10 mg
25 mg
原价
450
580
890
售价
450
580
890
库存
现货
现货
现货
订购
订购
订购
订购
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订购
  • 生物活性

    Rosuvastatin Calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Schneck DW, et al. Clin Pharmacol Ther, 2004, 75(5), 4554-63.

    分子式
    C44H54CaF2N6O12S2
    分子量
    500.57
    CAS号
    147098-20-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02569645 Rectal Cancer Drug: Rosuvastatin AHS Cancer Control Alberta|Ozmosis Research Inc. Phase 2 2015-11-01 2016-09-19
    NCT01218347 Organic Anion Transporting Polypeptide1B1 (OATP1B1)|Rosuvastatin Drug: Rosuvastatin Seoul National University Hospital Phase 4 2010-10-01 2011-01-04
    NCT00766025 CYP2C19 Poor|Extensive Metabolizers Drug: Rosuvastatin Calcium AstraZeneca Phase 1 2008-09-01 2009-02-27
    NCT01524601 Disorder Related to Renal Transplantation|Hypercholesterolemia Drug: Rosuvastatin University of Oslo School of Pharmacy|Oslo University Hospital Phase 4 2012-02-01 2012-10-11
    NCT02106767 Healthy Drug: Rosuvastatin|Drug: Rosuvastatin plus rifampin University of California, San Francisco Phase 1 2014-11-01 2015-12-01
    NCT01466608 Hypercholesterolemia Drug: Rosuvastatin Seoul National University Hospital Phase 4 2011-11-01 2014-05-15
    NCT01490398 Hypertension|Cardiovascular Risk Factors Drug: Rosuvastatin Asan Medical Center|AstraZeneca Phase 4 2011-12-01 2014-05-08
    NCT02215174 Statin Pharmacokinetics Pre and Post Gastric Bypass Surgery Drug: Rosuvastatin University of California, San Francisco|E-DA Hospital Phase 1 2015-02-01 2015-04-24
    NCT00463606 Hypercholesterolemia|Dyslipidemia Drug: ABT-335 and rosuvastatin calcium|Drug: ABT-335|Drug: rosuvastatin calcium AstraZeneca Phase 3 2007-04-01 2012-09-27
    NCT02705547 Friedreich Ataxia Drug: Rosuvastatin Children's Hospital of Philadelphia|Friedreich's Ataxia Research Alliance Early Phase 1 2016-05-01 2017-03-15
    NCT00986999 HIV Infections|Cardiovascular Disease Drug: rosuvastatin University of Hawaii Phase 2|Phase 3 2009-09-01 2015-01-20
    NCT00660764 Hypercholesterolemia|Coronary Heart Disease|Peripheral Vascular Disease|Cerebrovascular Accident|Diabetes Drug: Rosuvastatin AstraZeneca 2003-05-01 2009-03-13
    NCT02284503 Non-ST-elevation Acute Coronary Syndromes Drug: Rosuvastatin Shanghai Zhongshan Hospital Phase 4 2014-11-01 2014-11-03
    NCT00240318 Coronary Arteriosclerosis Drug: Rosuvastatin calcium AstraZeneca Phase 3 2002-11-01 2010-11-18
    NCT01382277 Hyperlipidemia|Coronary Artery Disease Drug: Rosuvastatin Peking University First Hospital Phase 4 2011-03-01 2011-06-23
    NCT00225589 Hypercholesteremia Drug: Rosuvastatin calcium AstraZeneca Phase 3 2002-08-01 2010-11-18
    NCT02083627 Drug-Drug Interaction (DDI)|Intestinal Absorption|Healthy Subjects|Pharmacokinetics of Rosuvastatin|Pharmacokinetics of Fidaxomicin Drug: rosuvastatin|Drug: fidaxomicin Astellas Pharma Europe B.V.|Cubist Pharmaceuticals LLC|Astellas Pharma Inc Phase 1 2013-02-01 2014-05-19
    NCT01863914 End-stage Kidney Disease|Diabetes Mellitus|Arteriovenous Fistula Drug: Rosuvastatin National Cheng-Kung University Hospital Phase 2 2012-11-01 2016-09-24
    NCT00966472 Squamous Cell Carcinoma|Non-Small Cell Lung Cancer Drug: Erlotinib + Rosuvastatin Ottawa Hospital Research Institute|Ozmosis Research Inc. Phase 1 2009-03-01 2015-04-21
    NCT00984932 Systemic Sclerosis Drug: Rosuvastatin Faculty of Medicine, University of Alexandria Phase 3 2008-09-01 2009-09-24
    NCT03007524 Acute Coronary Syndrome Drug: High dose Rosuvastatin|Drug: Low dose Rosuvastatin Nanjing First Hospital, Nanjing Medical University Phase 4 2016-07-01 2017-02-19

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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