Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.
Glycyrrhizin (Glycyrrhizic Acid) is a widely used anti-inflammatory agent isolated from the licorice root.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Mohammad, G. et al. 2013. High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina. Exp. Eye Res.. 107: 101-9.
[2] Abu El-Asrar, AM. et al. 2014. The proinflammatory cytokine high-mobility group box-1 mediates retinal neuropathy induced by diabetes. Mediators Inflamm.. 2014: 746415.
分子式 C42H62O16 |
分子量 822.93 |
CAS号 1405-86-3 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 120 mg/mL |
Water 30 mg/mL |
Ethanol 170 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02329314 | ShuGuang Hospital | All | 60 | 2016-06-01 | 2014-12-01 | |
NCT00686881 | Hepatitis C, Chronic | Biological: Peginterferon alfa-2b (PegIFN-2b)|Drug: Comparator: Stronger neo minophagen C (SNMC) | Merck Sharp & Dohme Corp. | Phase 3 | 2006-12-01 | 2015-09-04 |
NCT01643447 | Hepatocellular Carcinoma | Drug: Ulinastatin|Drug: Diammonium glycyrrhizinate | Eastern Hepatobiliary Surgery Hospital | 2012-05-01 | 2016-03-30 | |
NCT01342185 | Chronic Hepatitis B | Device: medical ozone therapy with tianyi|Device: medical ozone therapy with humares|Drug: Diammonium glycyrrhizinate Capsules | Nanfang Hospital of Southern Medical University|Tianyi medical instruments limited company, Ningbo, China | Phase 3 | 2010-03-01 | 2012-10-17 |
NCT02651350 | Drug-induced Liver Injury,Chronic | Drug: Methylprednisolone|Drug: Standard Treatment | Beijing 302 Hospital | Phase 1|Phase 2 | 2015-12-01 | 2016-11-15 |
NCT02449109 | Liver Cancer | Procedure: interventional therapy | Fuda Cancer Hospital, Guangzhou | Phase 1|Phase 2 | 2015-05-01 | 2016-02-23 |
NCT02449122 | Lung Cancer | Procedure: interventional therapy | Fuda Cancer Hospital, Guangzhou | Phase 1|Phase 2 | 2015-05-01 | 2016-02-23 |
NCT02449135 | Pancreatic Cancer | Procedure: interventional therapy | Fuda Cancer Hospital, Guangzhou | Phase 1|Phase 2 | 2015-05-01 | 2016-02-23 |
NCT02331745 | Liver Failure|Hepatitis B|Alcoholic Liver Disease | Drug: Granulocyte colony-stimulating factor|Drug: standard treatment | Beijing 302 Hospital | Phase 4 | 2013-10-01 | 2016-08-04 |
NCT02473458 | Acute Stroke | Drug: Licorice whole extract|Drug: Placebo | Shiraz University of Medical Sciences | Phase 1|Phase 2 | 2012-06-01 | 2015-06-11 |
NCT02251678 | Plaque Psoriasis | Dietary Supplement: Elimune Capsules | Elorac, Inc. | Phase 1 | 2014-09-01 | 2015-12-07 |
NCT01271296 | Addison Disease | Dietary Supplement: Liquorice|Dietary Supplement: Grapefruit Juice | Haukeland University Hospital | 2008-04-01 | 2011-01-13 | |
NCT00956891 | Liver Failure|Mesenchymal Stem Cells | Sun Yat-sen University | Phase 1|Phase 2 | 2005-05-01 | 2010-12-06 | |
NCT01742702 | Primary Hypertension|Secondary Hypertension|Aortic Stenosis|Renal Insufficiency | Drug: Nitroglycerin 0.25 mg (single dose)|Drug: Salbutamol 400 g (single dose)|Drug: L-arginine (10 min infusion)|Dietary Supplement: Liquorice (2 weeks, glycyrrhizin 290-370 mg daily)|Dietary Supplement: Small milk casein-derived polypeptides (yoghurt, 12 weeks daily)|Drug: Bisoprolol (5mg daily for 3 weeks) | University of Tampere|Finnish Foundation for Cardiovascular Research|Paavo Nurmi Foundation|Sigrid Juselius Foundation|Finnish Cultural Foundation|Tampere Tuberculosis Foundation|The Competitive Research Funding of Pirkanmaa Hospital District|Aarne Koskelo Foundation|Finnish Medical Foundation|Orion Farmos Research Foundation|Finnish Kidney Foundation | Early Phase 1 | 2006-06-01 | 2012-12-03 |
NCT00945568 | Hepatocellular Carcinoma|Chronic Liver Disease | Drug: Aminoleban EN | Kochi University | 2007-05-01 | 2009-07-23 | |
NCT02812121 | Liver Failure | Drug: umbilical cord blood mesenchymal stem cells | Sun Yat-sen University | Phase 2 | 2016-06-01 | 2016-06-21 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们