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Glycyrrhizin

甘草酸,Glycyrrhizic Acid

Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.

目录号
EY1285
EY1285
EY1285
纯度
99.46%
99.46%
99.46%
规格
50 mg
100 mg
500 mg
原价
480
685
1900
售价
480
685
1900
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Glycyrrhizin (Glycyrrhizic Acid) is a widely used anti-inflammatory agent isolated from the licorice root.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Mohammad, G. et al. 2013. High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina. Exp. Eye Res.. 107: 101-9.
    [2] Abu El-Asrar, AM. et al. 2014. The proinflammatory cytokine high-mobility group box-1 mediates retinal neuropathy induced by diabetes. Mediators Inflamm.. 2014: 746415.

    分子式
    C42H62O16
    分子量
    822.93
    CAS号
    1405-86-3
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    120 mg/mL
    Water
    30 mg/mL
    Ethanol
    170 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02329314 ShuGuang Hospital All 60 2016-06-01 2014-12-01
    NCT00686881 Hepatitis C, Chronic Biological: Peginterferon alfa-2b (PegIFN-2b)|Drug: Comparator: Stronger neo minophagen C (SNMC) Merck Sharp & Dohme Corp. Phase 3 2006-12-01 2015-09-04
    NCT01643447 Hepatocellular Carcinoma Drug: Ulinastatin|Drug: Diammonium glycyrrhizinate Eastern Hepatobiliary Surgery Hospital 2012-05-01 2016-03-30
    NCT01342185 Chronic Hepatitis B Device: medical ozone therapy with tianyi|Device: medical ozone therapy with humares|Drug: Diammonium glycyrrhizinate Capsules Nanfang Hospital of Southern Medical University|Tianyi medical instruments limited company, Ningbo, China Phase 3 2010-03-01 2012-10-17
    NCT02651350 Drug-induced Liver Injury,Chronic Drug: Methylprednisolone|Drug: Standard Treatment Beijing 302 Hospital Phase 1|Phase 2 2015-12-01 2016-11-15
    NCT02449109 Liver Cancer Procedure: interventional therapy Fuda Cancer Hospital, Guangzhou Phase 1|Phase 2 2015-05-01 2016-02-23
    NCT02449122 Lung Cancer Procedure: interventional therapy Fuda Cancer Hospital, Guangzhou Phase 1|Phase 2 2015-05-01 2016-02-23
    NCT02449135 Pancreatic Cancer Procedure: interventional therapy Fuda Cancer Hospital, Guangzhou Phase 1|Phase 2 2015-05-01 2016-02-23
    NCT02331745 Liver Failure|Hepatitis B|Alcoholic Liver Disease Drug: Granulocyte colony-stimulating factor|Drug: standard treatment Beijing 302 Hospital Phase 4 2013-10-01 2016-08-04
    NCT02473458 Acute Stroke Drug: Licorice whole extract|Drug: Placebo Shiraz University of Medical Sciences Phase 1|Phase 2 2012-06-01 2015-06-11
    NCT02251678 Plaque Psoriasis Dietary Supplement: Elimune Capsules Elorac, Inc. Phase 1 2014-09-01 2015-12-07
    NCT01271296 Addison Disease Dietary Supplement: Liquorice|Dietary Supplement: Grapefruit Juice Haukeland University Hospital 2008-04-01 2011-01-13
    NCT00956891 Liver Failure|Mesenchymal Stem Cells Sun Yat-sen University Phase 1|Phase 2 2005-05-01 2010-12-06
    NCT01742702 Primary Hypertension|Secondary Hypertension|Aortic Stenosis|Renal Insufficiency Drug: Nitroglycerin 0.25 mg (single dose)|Drug: Salbutamol 400 g (single dose)|Drug: L-arginine (10 min infusion)|Dietary Supplement: Liquorice (2 weeks, glycyrrhizin 290-370 mg daily)|Dietary Supplement: Small milk casein-derived polypeptides (yoghurt, 12 weeks daily)|Drug: Bisoprolol (5mg daily for 3 weeks) University of Tampere|Finnish Foundation for Cardiovascular Research|Paavo Nurmi Foundation|Sigrid Juselius Foundation|Finnish Cultural Foundation|Tampere Tuberculosis Foundation|The Competitive Research Funding of Pirkanmaa Hospital District|Aarne Koskelo Foundation|Finnish Medical Foundation|Orion Farmos Research Foundation|Finnish Kidney Foundation Early Phase 1 2006-06-01 2012-12-03
    NCT00945568 Hepatocellular Carcinoma|Chronic Liver Disease Drug: Aminoleban EN Kochi University 2007-05-01 2009-07-23
    NCT02812121 Liver Failure Drug: umbilical cord blood mesenchymal stem cells Sun Yat-sen University Phase 2 2016-06-01 2016-06-21

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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