Moxifloxacin Hydrochloride是一种第四代氟喹诺酮类抗生素。
Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Tuberculosis (Edinb), 2008, 88(2):127-131.
分子式 C21H24FN3O4.HCl |
分子量 437.89 |
CAS号 186826-86-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 88 mg/mL |
Water 24 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02016157 | Chronic Generalized Periodontitis | Drug: Moxifloxacin | Sri Hasanamba Dental College and Hospital | Phase 4 | 2011-09-01 | 2013-12-18 |
NCT01302951 | Side-effect of Antibiotic | Drug: Moxifloxacin 400 mg | University Hospital, Saarland|Bayer | Phase 4 | 2008-07-01 | 2011-02-23 |
NCT02595359 | Endophthalmitis | Drug: Moxifloxacin | Universidade Federal de Pernambuco | Phase 2 | 2013-01-01 | 2016-10-24 |
NCT02770729 | Endophthalmitis | Drug: Moxifloxacin|Drug: No injection of moxifloxacin | University of Campinas, Brazil | Phase 3 | 2017-01-01 | 2017-03-15 |
NCT01756521 | the Effect of Moxifloxacin on QT/QTc Interval | Drug: Moxifloxacin | Seoul National University Hospital|Korea National Enterprise for Clinical Trials|The Catholic University of Korea|Seoul National University Bundang Hospital | Phase 1 | 2013-01-01 | 2016-04-25 |
NCT01876316 | Healthy | Drug: Moxifloxacin|Drug: Placebo | Inje University | 2011-11-01 | 2013-06-11 | |
NCT00895089 | Liver Abscess | Drug: Moxifloxacin (Avelox)|Drug: ceftriaxone | Kaohsiung Veterans General Hospital.|Bayer | Phase 4 | 2009-05-01 | 2015-12-01 |
NCT02322619 | Healthy | Drug: Moxifloxacin Tablets 400 mg | Dr. Reddy's Laboratories Limited | Phase 1 | 2012-11-01 | 2014-12-18 |
NCT01055145 | TB | Drug: levofloxacin, moxifloxacin | Seoul National University Hospital | Phase 3 | 2010-03-01 | 2012-11-22 |
NCT01603030 | Eye Infection/Inflammation Other | Drug: moxifloxacin 0,5% + prednisolone 1%|Drug: moxifloxacin/prednisolone combination | Adapt Produtos Oftalmolgicos Ltda. | Phase 3 | 2012-06-01 | 2012-05-21 |
NCT01130922 | Gastric Bypass|Body Weight | Drug: moxifloxacin per IV|Drug: moxifloxacin per os | University Ghent | Phase 4 | 2010-03-01 | 2011-04-15 |
NCT02176005 | Healthy | Device: DAV132|Drug: Moxifloxacin|Other: Negative Control | Da Volterra | Phase 1 | 2014-03-01 | 2016-02-03 |
NCT01642485 | Effects of Different Meals on the QT/QTc Interval|Insulin and Oral Hypoglycemic [Antidiabetic] Drugs Causing Adverse Effects in Therapeutic Use|C-Peptide Effects on the QT/QTc Interval|Moxifloxacin ECG Profile in Fed and Fasted State|Japanese vs. Caucasian TQT Comparison | Drug: Moxifloxacin 400 mg fasted|Other: FDA breakfast|Other: Continental breakfast|Drug: Moxifloxacin 400 mg fed|Procedure: Insulin Clamp|Drug: Placebo | Richmond Pharmacology Limited | Phase 1 | 2011-07-01 | 2014-08-19 |
NCT02531438 | Bacterial Pneumonia|Community-Acquired Infections | Drug: Omadacycline|Drug: Moxifloxacin | Paratek Pharmaceuticals Inc | Phase 3 | 2015-11-01 | 2017-01-24 |
NCT00805558 | Chronic Periodontitis | Drug: moxifloxacin|Drug: Ciprofloxacin plus metronidazole | Facultad Nacional de Salud Publica|Universidad de Antioquia | Phase 4 | 2009-02-01 | 2010-05-10 |
NCT00764582 | Corneal Transplantation | Drug: 1.5% levofloxacin ophthalmic solution|Drug: 0.5% moxifloxacin ophthalmic solution | Santen Inc.|Vistakon Pharmaceuticals | Phase 4 | 2008-09-01 | 2009-08-24 |
NCT01653990 | QT Interval Prolongation | Drug: moxifloxacin|Drug: moxifloxacin-placebo | Peking University Third Hospital | 2012-07-01 | 2012-07-30 | |
NCT00728507 | Tuberculosis | Drug: Rifapentine, Moxifloxacin, Pyrazinamide, Isoniazid|Drug: Isoniazid, Rifampin, Pyrazinamide, Ethambutol | Johns Hopkins University|Universidade Federal do Rio de Janeiro|Municipal Health Secretary of Rio de Janeiro|Helio Fraga Reference Center, Fiocruz | Phase 2 | 2009-11-01 | 2013-04-01 |
NCT01191723 | Healthy | Drug: MAP0004|Drug: Inhaler Placebo|Drug: Moxifloxacin|Drug: Placebo Capsule | Allergan|MAP Pharmaceuticals, Inc., a wholly owned subsidiary of Allergan | Phase 1 | 2010-08-01 | 2013-12-09 |
NCT00887276 | Community Acquired Pneumonia | Drug: Moxifloxacin|Drug: Ampicillin;Amoxicillin | University of Ulm|CAPNETZ Stiftung | Phase 4 | 2008-11-01 | 2014-12-16 |
NCT00398411 | Hodgkin Disease|Non-Hodgkin Lymphoma|Multiple Myeloma|Bacteremia | Drug: moxifloxacin|Drug: placebo | University of Cologne | Phase 3 | 2006-10-01 | 2015-06-01 |
NCT00840580 | Cataract Extraction | Drug: Moxifloxacin 0.5% ophthalmic solution (Vigamox)|Drug: Levofloxacin 0.5% ophthalmic solution (Cravit) | Alcon Research | Phase 4 | 2009-01-01 | 2012-07-19 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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