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Loperamide HCl

盐酸洛哌丁胺,ADL 2-1294,Imodium

Loperamide hydrochloride是阿片类受体激动剂，是长效止泻剂。

目录号
EY1268
EY1268
纯度
99.16%
99.16%
规格
100 mg
500 mg
原价
470
770
售价
470
770
库存
现货
现货
订购
订购
订购
订购
订购
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  • 生物活性

    Loperamide HCl is a selective μ-opioid receptor agonist opioid with Ki of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] DeHaven-Hudkins DL, et al. J Pharmacol Exp Ther,?999, 289(1), 494-502.

    分子式
    C29H34Cl2N2O2    		 分子量
    513.5    		 CAS号
    34552-83-5    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    22 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    4 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00778115 Healthy Drug: Loperamide HCl 2 mg and simethicone 125 mg tablets Ranbaxy Laboratories Limited|Ranbaxy Inc. 2004-11-01 2008-10-22
    NCT02711891 Pain Drug: Loperamide|Drug: Drug, placebo gel Rush University Medical Center Early Phase 1 2015-03-01 2016-03-16
    NCT00591357 Antibiotic-Associated Diarrhea|Clostridium Difficile Drug: loperamide|Drug: placebo VA Medical Center, Houston Phase 4 2007-10-01 2016-05-02
    NCT02263365 Dehydration, Diverting Ileostomy, Loperamide Drug: Loperamide Cedars-Sinai Medical Center Phase 3 2014-10-01 2017-01-30
    NCT02266849 Rectal Cancer|Ulcerative Colitis|Short Bowel Syndrome Drug: Loperamide|Drug: Placebo Odense University Hospital Phase 3 2014-10-01 2016-10-09
    NCT00806299 Drug Interaction Drug: Loperamide / Red Grapefruit Juice|Drug: Loperamide/ White Grapefruit Juice|Drug: Loperamide / Pink Grapefruit Juice Johnson & Johnson Consumer and Personal Products Worldwide Phase 1 2008-11-01 2011-10-04
    NCT02008565 Fecal Incontinence Drug: Loperamide|Drug: Placebo|Behavioral: Anal exercises with biofeedback|Behavioral: Usual Care NICHD Pelvic Floor Disorders Network|The Cleveland Clinic|University of Alabama at Birmingham|University of California, San Diego|Duke University|National Institutes of Health (NIH)|University of New Mexico|Women and Infants Hospital of Rhode Island|RTI International|University of Pennsylvania|University of Pittsburgh|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 3 2014-02-01 2016-08-12
    NCT00359970 Diarrhea Drug: Azithromycin 500 mg|Drug: Azithromycin 1000 mg|Drug: Loperamide|Other: Placebo The University of Texas Health Science Center, Houston Phase 4 2002-06-01 2015-06-17
    NCT02340481 Diarrhea Drug: Loperamide hydrochloride + simethicone chewable tablet|Drug: Loperamide hydrochloride|Drug: Loperamide hydrochloride + simethicone chewable placebo tablet|Drug: Loperamide hydrochloride placebo capsule Xian-Janssen Pharmaceutical Ltd. Phase 3 2005-07-01 2016-01-06
    NCT00933465 Fecal Incontinence Drug: Imodium (Loperamide Hydrochloride) syrup|Drug: Imodium (Loperamide hydrochloride) tablets University Hospital Southampton NHS Foundation Trust|University of Southampton Phase 4 2009-10-01 2014-11-17
    NCT00292344 Travelers' Diarrhea Drug: Rifaximin and loperamide The University of Texas Health Science Center, Houston|Valeant Pharmaceuticals International, Inc. Phase 4 2004-06-01 2009-04-17
    NCT02400476 Early Stage HER2+ Breast Cancer Drug: Neratinib|Drug: Loperamide|Drug: Budesonide|Drug: Colestipol|Drug: Bismuth Subsalicylate or Mesalamine Puma Biotechnology, Inc. Phase 2 2015-02-01 2017-02-17
    NCT00807326 Diarrhea Drug: Loperamide/simeticone 2 mg/125 mg caplets|Drug: Loperamide/simeticone 2 mg/125 mg chewable tablets|Drug: Probiotic Saccharomyces boulardii 250 mg capsules McNeil AB|Johnson & Johnson Consumer and Personal Products Worldwide Phase 4 2008-11-01 2012-07-06
    NCT00685607 Diarrhea Drug: loperamide-simethicone|Drug: matching placebo Johnson & Johnson Consumer and Personal Products Worldwide Phase 4 2008-10-01 2011-10-04
    NCT00003057 Colorectal Cancer|Diarrhea Drug: loperamide hydrochloride|Drug: octreotide acetate Eastern Cooperative Oncology Group|National Cancer Institute (NCI)|Southwest Oncology Group|Cancer and Leukemia Group B Phase 3 1996-11-01 2009-05-09
    NCT02251119 Healthy Drug: Tipranavir|Drug: Ritonavir|Drug: Loperamide Boehringer Ingelheim Phase 1 2002-07-01 2014-09-25
    NCT01596764 Intestinal Obstruction Drug: Loperamide placebo|Drug: Loperamide|Device: Colon Transit|Drug: Sulfasalazine|Drug: Placebo of MNTX and NLX|Drug: Naloxone|Drug: Methylnaltrexone University Medicine Greifswald Phase 1 2011-05-01 2012-05-09
    NCT02217982 Relapsing Remitting Multiple Sclerosis Drug: Simethicone|Drug: Loperamide|Other: Peanut Butter Rocky Mountain MS Research Group, LLC|Biogen Phase 4 2014-07-01 2017-02-20
    NCT01596777 Intestinal Obstruction Drug: Loperamide|Drug: Loperamide placebo|Drug: Methylnaltrexone placebo|Drug: Methylnaltrexone 12 mg sc.|Drug: Methylnaltrexone IR capsule|Drug: Methylnaltrexone ER capsule|Device: Colon Transit|Drug: Sulfasalazine University Medicine Greifswald Phase 1 2010-01-01 2016-10-25
    NCT00444093 Diarrhea|Enteritis|Cancer Drug: Tinctura opii Philipps University Marburg Medical Center|Maros Arzneimittel GmbH Phase 3 2007-09-01 2007-08-31

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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