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Prasugrel

普拉格雷,CS-747,LY640315,CS 747,CS747,LY 640315,LY-640315,

Prasugrel是ADP受体抑制剂，能通过不可逆的与P2Y12受体结合降低血小板的聚集。

目录号
EY1266
EY1266
EY1266
纯度
99.69%
99.69%
99.69%
规格
50 mg
100 mg
500 mg
原价
420
620
1900
售价
420
620
1900
库存
现货
现货
现货
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  • 生物活性

    Prasugrel is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Hashimoto M, et al. Biochem Pharmacol, 2007, 74(7), 1003-1009.

    分子式
    C20H20FNO3S    		 分子量
    373.44    		 CAS号
    150322-43-3    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    30 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    7 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02212028 Coronary Artery Disease Drug: prasugrel University of Florida Phase 4 2014-10-01 2016-11-01
    NCT01493999 Acute Coronary Syndrome Drug: Clopidogrel reloading|Drug: Prasugrel University of Pecs Phase 4 2011-09-01 2014-10-06
    NCT01260584 Coronary Artery Disease Drug: Prasugrel|Drug: Clopidogrel Daiichi Sankyo Inc. Phase 4 2010-11-01 2012-11-12
    NCT01476696 Sickle Cell Disease Drug: Prasugrel Eli Lilly and Company|Daiichi Sankyo Inc. Phase 2 2011-11-01 2014-01-17
    NCT01560780 Coronary Artery Bypass Drug: Prasugrel|Drug: Placebo VA Office of Research and Development Phase 3 2013-02-01 2017-03-22
    NCT01115738 Acute Coronary Syndrome Drug: Prasugrel|Drug: Clopidogrel|Drug: Placebo Eli Lilly and Company Phase 2 2010-05-01 2012-11-15
    NCT01014624 Coronary Artery Disease Drug: prasugrel|Drug: clopidogrel Daiichi Sankyo Inc. Phase 4 2010-02-01 2012-02-08
    NCT01201772 Coronary Artery Disease Drug: Prasugrel University of Florida Phase 4 2010-08-01 2013-01-17
    NCT01835353 Platelet Reactivity Drug: Prasugrel 100mg loading dose|Drug: Prasugrel 60mg loading dose University of Patras Phase 3 2012-06-01 2013-09-20
    NCT01178099 Anemia, Sickle Cell Drug: Prasugrel Eli Lilly and Company|Daiichi Sankyo Co., Ltd. Phase 1 2010-07-01 2012-01-12
    NCT01852175 Coronary Artery Disease Drug: Prasugrel|Drug: Ticagrelor University of Florida 2012-01-01 2015-05-26
    NCT01852214 Diabetes Mellitus|Coronary Artery Disease Drug: Prasugrel|Drug: Ticagrelor University of Florida 2013-02-01 2016-08-22
    NCT01365221 Acute Coronary Syndrome Drug: Prasugrel|Drug: Prasugrel Medstar Health Research Institute Phase 4 2010-12-01 2013-10-31
    NCT01641510 Acute Coronary Syndromes Drug: Prasugrel|Drug: Clopidogrel Dong-A University Phase 3 2013-10-01 2016-10-25
    NCT01531114 ST-Elevation Myocardial Infarction Drug: ticagrelor|Drug: prasugrel Gennaro Sardella|University of Roma La Sapienza Phase 3 2013-05-01 2017-01-31
    NCT01591317 Healthy Volunteers Drug: Prasugrel Eli Lilly and Company Phase 1 2009-03-01 2012-09-04
    NCT02070159 Coronary Artery Disease Drug: Clopidogrel 600 mg|Drug: Prasugrel 30 mg|Drug: Prasugrel 60 mg Dong-A University Phase 3 2011-12-01 2014-02-21
    NCT01465828 Acute Coronary Syndrome Drug: Clopidogrel|Drug: prasugrel Gennaro Sardella|University of Roma La Sapienza Phase 3 2011-10-01 2012-03-24
    NCT02075125 ST-Segment Elevation Myocardial Infarction Drug: Prasugrel 60 mg|Drug: Ticagrelor 180 mg Dong-A University Phase 3 2014-01-01 2016-03-02
    NCT01778842 Coronary Artery Disease Drug: Clopidogrel|Drug: Prasugrel Gennaro Sardella|University of Roma La Sapienza Phase 3 2013-03-01 2013-01-24
    NCT01852019 Coronary Artery Disease Drug: Cangrelor|Drug: Prasugrel The Medicines Company Phase 2 2013-06-01 2015-05-27
    NCT01876797 Healthy Drug: ticagrelor/prasugrel Asan Medical Center Phase 1 2013-07-01 2014-02-27
    NCT01430091 Sickle Cell Disease Drug: Prasugrel (clinical formulation)|Drug: Prasugrel (Orally Disintegrating Tablet [ODT]) Eli Lilly and Company Phase 1 2011-09-01 2012-10-05
    NCT01951001 Acute Coronary Syndrome|Platelet Thrombus|Bleeding Drug: Prasugrel Gyeongsang National University Hospital Phase 4 2013-07-01 2014-04-30
    NCT02065479 Coronary Artery Disease Drug: Prasugrel|Drug: Ticagrelor University of Florida Phase 4 2014-03-01 2016-10-11

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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