Maprotiline HCl

盐酸马普替林

Maprotiline盐酸盐是去甲肾上腺素重吸收抑制剂,为四环抗抑郁化合物(TeCA)。

目录号
EY1265
EY1265
纯度
99.58%
99.58%
规格
100 mg
500 mg
原价
420
890
售价
420
890
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Maprotiline HCl is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Ferrer-Villada T, et al. Eur J Pharmacol,?006, 531(1-3), 1-8.

    分子式
    C20H24ClN
    分子量
    313.86
    CAS号
    10347-81-6
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    64 mg/mL
    Water
    <1 mg/mL
    Ethanol
    25 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00704860 Major Depression Other: Open label pharmacotherapy University of Ottawa Phase 4 2005-02-01 2011-01-18
    NCT02873234 Depression Drug: Traditional Chinese Medicine|Drug: Antidepressants The Third Affiliated Hospital of Beijing University of Chinese Medicine|Guang'anmen Hospital of China Academy of Chinese Medical Sciences|Beijing HuiLongGuan Hospital|The First Affiliated Hospital of Henan University of Traditional Chinese Medicine|First Affiliated Hospital of Heilongjiang Chinese Medicine University|The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine|Shandong University of Traditional Chinese Medicine|Capital Medical University|Xiamen Hospital of Traditional Chinese Medicine|Wu Xi Hospital of Traditional Chinese Medicine 2016-06-01 2016-08-18
    NCT02374567 Dementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety Disorders Drug: Phenobarbital|Drug: Phenytoin|Drug: Carbamazepine|Drug: Oxcarbazepine|Drug: Valproic Acid|Drug: Lamotrigine|Drug: Topiramate|Drug: Gabapentin|Drug: Levetiracetam|Drug: Pregabalin|Drug: Lacosamide|Drug: Clonazepam|Drug: Biperiden|Drug: Levomepromazine|Drug: Fluphenazine|Drug: Perphenazine|Drug: Perazine|Drug: Thioridazine|Drug: Haloperidol|Drug: Melperone|Drug: Pipamperone|Drug: Bromperidol|Drug: Benperidol|Drug: Sertindole|Drug: Ziprasidone|Drug: Flupentixol|Drug: Chlorprothixene|Drug: Zuclopenthixol|Drug: Fluspirilene|Drug: Pimozide|Drug: Clozapine|Drug: Olanzapine|Drug: Quetiapine|Drug: Sulpiride|Drug: Tiapride|Drug: Amisulpride|Drug: Prothipendyl|Drug: Risperidone|Drug: Aripiprazole|Drug: Paliperidone|Drug: Diazepam|Drug: Oxazepam|Drug: Lorazepam|Drug: Bromazepam|Drug: Clobazam|Drug: Alprazolam|Drug: Hydroxyzine|Drug: Buspirone|Drug: Chloral Hydrate|Drug: Flurazepam|Drug: Nitrazepam|Drug: Triazolam|Drug: Lormetazepam|Drug: Temazepam|Drug: Midazolam|Drug: Brotizolam|Drug: Zopiclone|Drug: Zolpidem|Drug: Zaleplon|Drug: Melatonin|Drug: Clomethiazole|Drug: Diphenhydramine|Drug: Promethazine|Drug: Imipramine|Drug: Clomipramine|Drug: Opipramol|Drug: Trimipramine|Drug: Amitriptyline|Drug: Nortriptyline|Drug: Doxepin|Drug: Maprotiline|Drug: Amitriptyline oxide|Drug: Fluoxetine|Drug: Citalopram|Drug: Paroxetine|Drug: Sertraline|Drug: Fluvoxamine|Drug: Escitalopram|Drug: Tranylcypromine|Drug: Moclobemide|Drug: Mianserin|Drug: Trazodone|Drug: Mirtazapine|Drug: Bupropion|Drug: Venlafaxine|Drug: Reboxetine|Drug: Duloxetine|Drug: Agomelatine|Drug: Pyritinol|Drug: Piracetam|Drug: Donepezil|Drug: Rivastigmine|Drug: Galantamine|Drug: Memantine|Drug: Nicergoline|Drug: Acamprosate|Drug: Lithium Hannover Medical School Phase 3 2015-01-01 2017-02-23

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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