Maprotiline盐酸盐是去甲肾上腺素重吸收抑制剂,为四环抗抑郁化合物(TeCA)。
Maprotiline HCl is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Ferrer-Villada T, et al. Eur J Pharmacol,?006, 531(1-3), 1-8.
分子式 C20H24ClN |
分子量 313.86 |
CAS号 10347-81-6 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 64 mg/mL |
Water <1 mg/mL |
Ethanol 25 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00704860 | Major Depression | Other: Open label pharmacotherapy | University of Ottawa | Phase 4 | 2005-02-01 | 2011-01-18 |
NCT02873234 | Depression | Drug: Traditional Chinese Medicine|Drug: Antidepressants | The Third Affiliated Hospital of Beijing University of Chinese Medicine|Guang'anmen Hospital of China Academy of Chinese Medical Sciences|Beijing HuiLongGuan Hospital|The First Affiliated Hospital of Henan University of Traditional Chinese Medicine|First Affiliated Hospital of Heilongjiang Chinese Medicine University|The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine|Shandong University of Traditional Chinese Medicine|Capital Medical University|Xiamen Hospital of Traditional Chinese Medicine|Wu Xi Hospital of Traditional Chinese Medicine | 2016-06-01 | 2016-08-18 | |
NCT02374567 | Dementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety Disorders | Drug: Phenobarbital|Drug: Phenytoin|Drug: Carbamazepine|Drug: Oxcarbazepine|Drug: Valproic Acid|Drug: Lamotrigine|Drug: Topiramate|Drug: Gabapentin|Drug: Levetiracetam|Drug: Pregabalin|Drug: Lacosamide|Drug: Clonazepam|Drug: Biperiden|Drug: Levomepromazine|Drug: Fluphenazine|Drug: Perphenazine|Drug: Perazine|Drug: Thioridazine|Drug: Haloperidol|Drug: Melperone|Drug: Pipamperone|Drug: Bromperidol|Drug: Benperidol|Drug: Sertindole|Drug: Ziprasidone|Drug: Flupentixol|Drug: Chlorprothixene|Drug: Zuclopenthixol|Drug: Fluspirilene|Drug: Pimozide|Drug: Clozapine|Drug: Olanzapine|Drug: Quetiapine|Drug: Sulpiride|Drug: Tiapride|Drug: Amisulpride|Drug: Prothipendyl|Drug: Risperidone|Drug: Aripiprazole|Drug: Paliperidone|Drug: Diazepam|Drug: Oxazepam|Drug: Lorazepam|Drug: Bromazepam|Drug: Clobazam|Drug: Alprazolam|Drug: Hydroxyzine|Drug: Buspirone|Drug: Chloral Hydrate|Drug: Flurazepam|Drug: Nitrazepam|Drug: Triazolam|Drug: Lormetazepam|Drug: Temazepam|Drug: Midazolam|Drug: Brotizolam|Drug: Zopiclone|Drug: Zolpidem|Drug: Zaleplon|Drug: Melatonin|Drug: Clomethiazole|Drug: Diphenhydramine|Drug: Promethazine|Drug: Imipramine|Drug: Clomipramine|Drug: Opipramol|Drug: Trimipramine|Drug: Amitriptyline|Drug: Nortriptyline|Drug: Doxepin|Drug: Maprotiline|Drug: Amitriptyline oxide|Drug: Fluoxetine|Drug: Citalopram|Drug: Paroxetine|Drug: Sertraline|Drug: Fluvoxamine|Drug: Escitalopram|Drug: Tranylcypromine|Drug: Moclobemide|Drug: Mianserin|Drug: Trazodone|Drug: Mirtazapine|Drug: Bupropion|Drug: Venlafaxine|Drug: Reboxetine|Drug: Duloxetine|Drug: Agomelatine|Drug: Pyritinol|Drug: Piracetam|Drug: Donepezil|Drug: Rivastigmine|Drug: Galantamine|Drug: Memantine|Drug: Nicergoline|Drug: Acamprosate|Drug: Lithium | Hannover Medical School | Phase 3 | 2015-01-01 | 2017-02-23 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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