Zanamivir是流感病毒神经氨酸苷酶抑制剂,是唾液酸结构类似物。
            
         Zanamivir is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.
| 					 						 动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数  | 									 | 			
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
	
                      
                              [1] Gubareva LV, et al. J Infect Dis, 1998, 178(6), 1592-1596.
                          
                      
                      
                      
                      
                      
                      
                      
                      
                      
                   
| 分子式  C12H20N4O7  | 
                        分子量 332.31  | 
                        CAS号 139110-80-8  | 
                        储存方式 ﹣20 ℃冷藏长期储存。冰袋运输  | 
                     
| 溶剂(常温) | 
                        DMSO 2 mg/mL  | 
                        Water 25 mg/mL  | 
                        Ethanol <1 mg/mL  | 
                     
体内溶解度 
| NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated | 
| NCT02377401 | Influenza, Human | Drug: Zanamivir | GlaxoSmithKline | Phase 1 | 2015-04-01 | 2016-02-08 | 
| NCT01527110 | Influenza, Human | Drug: Intravenous (IV) zanamivir | GlaxoSmithKline | Phase 3 | 2012-01-01 | 2017-01-25 | 
| NCT01390792 | Influenza, Human | Drug: Zanamivir hydrate | GlaxoSmithKline | 2007-01-01 | 2011-07-14 | |
| NCT00540501 | Healthy Subjects | Drug: Oseltamivir and Intravenous Zanamivir | GlaxoSmithKline | Phase 1 | 2007-10-01 | 2010-05-27 | 
| NCT00784784 | Influenza | Biological: Fluviral|Drug: Zanamivir | Mount Sinai Hospital, Canada|GlaxoSmithKline | Phase 3 | 2008-11-01 | 2014-11-07 | 
| NCT01014988 | Influenza, Human | Drug: zanamivir aqueous solution | GlaxoSmithKline | Phase 2 | 2009-11-01 | 2016-08-12 | 
| NCT01231620 | Influenza, Human | Drug: Zanamivir|Drug: Placebo to match zanamivir|Drug: Oseltamivir|Drug: Placebo to match oseltamivir | GlaxoSmithKline | Phase 3 | 2011-01-01 | 2017-01-16 | 
| NCT01462487 | Influenza, Human | Drug: Treatment with zanamivir | GlaxoSmithKline | 2011-07-01 | 2014-04-17 | |
| NCT01199744 | Influenza, Human | Drug: zanamivir | GlaxoSmithKline | 2009-11-01 | 2011-11-17 | |
| NCT00921726 | Influenza|Virus Diseases | Drug: Zanamivir|Drug: Oseltamivir | National Institute of Allergy and Infectious Diseases (NIAID)|Johns Hopkins Bloomberg School of Public Health | Phase 1 | 2009-07-01 | 2010-03-18 | 
| NCT00989404 | Influenza A Virus, H1N1 Subtype | Drug: Zanamivir|Drug: Zanamivir|Drug: Zanamivir | GlaxoSmithKline | Phase 1 | 2009-10-01 | 2016-10-11 | 
| NCT00799760 | Gastric Influenza | Drug: oseltamivir + zanamivir|Drug: oseltamivir + zanamivir's placebo|Drug: oseltamivir's placebo + zanamivir | Assistance Publique - Hpitaux de Paris|Hoffmann-La Roche|GlaxoSmithKline | Phase 3 | 2008-12-01 | 2012-03-16 | 
| NCT01459081 | Influenza A Virus Infection|Influenza B Virus Infection | Drug: Zanamivir|Drug: Placebo | Jiangsu Simcere Pharmaceutical Co., Ltd. | Phase 3 | 2011-10-01 | 2013-01-15 | 
| NCT00980109 | Influenza | Drug: active oseltamivir|Drug: placebo capsule|Drug: zanamivir for inhalation|Drug: placebo for inhalation | University of Oxford|National Institute of Allergy and Infectious Diseases (NIAID) | Phase 4 | 2009-09-01 | 2010-09-21 | 
| NCT00979667 | Upper Respiratory Tract Infection|Influenza | Drug: Oseltamivir|Drug: Zanamivir|Drug: Placebo of Oseltamivir | Chinese University of Hong Kong|Food and Health Bureau, Hong Kong|Hospital Authority | Phase 3 | 2009-10-01 | 2011-04-08 | 
| NCT01156701 | Pulmonary Disease, Chronic Obstructive|Bronchospasm|Influenza, Human|Asthma|Respiratory Disease|Exacerbation of COPD|Bronchitis|Otitis Maedia|Pneumonia|Sinusitis | Drug: Receiving a prescription of Relenza for prophylaxis|Other: No prophylaxis with Relenza | GlaxoSmithKline | 2009-07-01 | 2011-06-02 | |
| NCT01353729 | Influenza, Human | Drug: 600 mg zanamivir + moxifoxacin placebo|Drug: 1200 mg zanamivir + moxacin placebo|Drug: zanamivir placebo + moxifloxacin placebo|Drug: zanamivir placebo + 400 mg moxifloxacin | GlaxoSmithKline | Phase 1 | 2011-05-01 | 2016-11-30 | 
| NCT01353768 | Infections, Respiratory Tract | Other: retrospective chart review | GlaxoSmithKline | 2011-07-01 | 2016-11-21 | |
| NCT00830323 | Influenza A Infection | Drug: oseltamivir + zanamivir|Drug: oseltamivir+ amantadine|Drug: oseltamivir | Hospices Civils de Lyon | Phase 2 | 2009-01-01 | 2010-09-29 | 
| NCT00867139 | Influenza | Drug: TCAD|Drug: Zanamivir or Oseltamivir|Other: Open label treatment with TCAD | Fred Hutchinson Cancer Research Center | Phase 1|Phase 2 | 2009-03-01 | 2013-08-08 | 
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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