Zanamivir是流感病毒神经氨酸苷酶抑制剂,是唾液酸结构类似物。
Zanamivir is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Gubareva LV, et al. J Infect Dis, 1998, 178(6), 1592-1596.
分子式 C12H20N4O7 |
分子量 332.31 |
CAS号 139110-80-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 2 mg/mL |
Water 25 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02377401 | Influenza, Human | Drug: Zanamivir | GlaxoSmithKline | Phase 1 | 2015-04-01 | 2016-02-08 |
NCT01527110 | Influenza, Human | Drug: Intravenous (IV) zanamivir | GlaxoSmithKline | Phase 3 | 2012-01-01 | 2017-01-25 |
NCT01390792 | Influenza, Human | Drug: Zanamivir hydrate | GlaxoSmithKline | 2007-01-01 | 2011-07-14 | |
NCT00540501 | Healthy Subjects | Drug: Oseltamivir and Intravenous Zanamivir | GlaxoSmithKline | Phase 1 | 2007-10-01 | 2010-05-27 |
NCT00784784 | Influenza | Biological: Fluviral|Drug: Zanamivir | Mount Sinai Hospital, Canada|GlaxoSmithKline | Phase 3 | 2008-11-01 | 2014-11-07 |
NCT01014988 | Influenza, Human | Drug: zanamivir aqueous solution | GlaxoSmithKline | Phase 2 | 2009-11-01 | 2016-08-12 |
NCT01231620 | Influenza, Human | Drug: Zanamivir|Drug: Placebo to match zanamivir|Drug: Oseltamivir|Drug: Placebo to match oseltamivir | GlaxoSmithKline | Phase 3 | 2011-01-01 | 2017-01-16 |
NCT01462487 | Influenza, Human | Drug: Treatment with zanamivir | GlaxoSmithKline | 2011-07-01 | 2014-04-17 | |
NCT01199744 | Influenza, Human | Drug: zanamivir | GlaxoSmithKline | 2009-11-01 | 2011-11-17 | |
NCT00921726 | Influenza|Virus Diseases | Drug: Zanamivir|Drug: Oseltamivir | National Institute of Allergy and Infectious Diseases (NIAID)|Johns Hopkins Bloomberg School of Public Health | Phase 1 | 2009-07-01 | 2010-03-18 |
NCT00989404 | Influenza A Virus, H1N1 Subtype | Drug: Zanamivir|Drug: Zanamivir|Drug: Zanamivir | GlaxoSmithKline | Phase 1 | 2009-10-01 | 2016-10-11 |
NCT00799760 | Gastric Influenza | Drug: oseltamivir + zanamivir|Drug: oseltamivir + zanamivir's placebo|Drug: oseltamivir's placebo + zanamivir | Assistance Publique - Hpitaux de Paris|Hoffmann-La Roche|GlaxoSmithKline | Phase 3 | 2008-12-01 | 2012-03-16 |
NCT01459081 | Influenza A Virus Infection|Influenza B Virus Infection | Drug: Zanamivir|Drug: Placebo | Jiangsu Simcere Pharmaceutical Co., Ltd. | Phase 3 | 2011-10-01 | 2013-01-15 |
NCT00980109 | Influenza | Drug: active oseltamivir|Drug: placebo capsule|Drug: zanamivir for inhalation|Drug: placebo for inhalation | University of Oxford|National Institute of Allergy and Infectious Diseases (NIAID) | Phase 4 | 2009-09-01 | 2010-09-21 |
NCT00979667 | Upper Respiratory Tract Infection|Influenza | Drug: Oseltamivir|Drug: Zanamivir|Drug: Placebo of Oseltamivir | Chinese University of Hong Kong|Food and Health Bureau, Hong Kong|Hospital Authority | Phase 3 | 2009-10-01 | 2011-04-08 |
NCT01156701 | Pulmonary Disease, Chronic Obstructive|Bronchospasm|Influenza, Human|Asthma|Respiratory Disease|Exacerbation of COPD|Bronchitis|Otitis Maedia|Pneumonia|Sinusitis | Drug: Receiving a prescription of Relenza for prophylaxis|Other: No prophylaxis with Relenza | GlaxoSmithKline | 2009-07-01 | 2011-06-02 | |
NCT01353729 | Influenza, Human | Drug: 600 mg zanamivir + moxifoxacin placebo|Drug: 1200 mg zanamivir + moxacin placebo|Drug: zanamivir placebo + moxifloxacin placebo|Drug: zanamivir placebo + 400 mg moxifloxacin | GlaxoSmithKline | Phase 1 | 2011-05-01 | 2016-11-30 |
NCT01353768 | Infections, Respiratory Tract | Other: retrospective chart review | GlaxoSmithKline | 2011-07-01 | 2016-11-21 | |
NCT00830323 | Influenza A Infection | Drug: oseltamivir + zanamivir|Drug: oseltamivir+ amantadine|Drug: oseltamivir | Hospices Civils de Lyon | Phase 2 | 2009-01-01 | 2010-09-29 |
NCT00867139 | Influenza | Drug: TCAD|Drug: Zanamivir or Oseltamivir|Other: Open label treatment with TCAD | Fred Hutchinson Cancer Research Center | Phase 1|Phase 2 | 2009-03-01 | 2013-08-08 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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