Rebamipide是内源性前列腺素诱导剂,同时是自由基清除剂。
Rebamipide is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Iinuma, S., et al. 1998. Dig Dis Sci. 43: 35S-39S. PMID: 9753224
[2] Otsubo, K., et al. 1991. Chem Pharm Bull. 39: 2906-2909. PMID: 1666022
分子式 C19H15ClN2O4 |
分子量 370.79 |
CAS号 90098-04-7 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 74 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00996788 | Dyspepsia|Chronic Gastritis | Drug: Rebamipide | PT Otsuka Indonesia | Phase 3 | 2007-10-01 | 2013-05-14 |
NCT00997789 | Therapeutic Equivalency|Pharmacogenetics | Drug: Rebamide | Chonnam National University Hospital|Institute of Bioequivalence and Bridging Study, College of Pharmacy, CNU | 2008-03-01 | 2009-10-18 | |
NCT01167101 | Stomach Ulcer | Drug: Rebamipide|Drug: pantoprazole | Kangdong Sacred Heart Hospital | 2009-05-01 | 2015-09-03 | |
NCT00463151 | Colitis, Ulcerative | Drug: rebamipide | Otsuka Pharmaceutical Co., Ltd. | Phase 2 | 2007-06-01 | 2011-02-09 |
NCT00272467 | Stomach Ulcer | Drug: Rebamipide|Drug: Omeprazole | Korea Otsuka International Asia Arab|Zhejiang Otsuka Pharmaceutical Co., Ltd.|Korea Otsuka Pharmaceutical Co., Ltd. | Phase 4 | 2005-07-01 | 2015-04-27 |
NCT02755753 | Gastroesophageal Reflux | Drug: Lansoprazole|Drug: Rebamipide|Drug: Rebamipide-placebo | YongChan Lee|Otsuka Pharmaceutical Co., Ltd.|Severance Hospital | Phase 4 | 2014-01-01 | 2016-04-26 |
NCT02393430 | Gastritis | Drug: Rebamipide|Behavioral: optimization of life style | BangMao Wang|Tianjin Medical University General Hospital | Phase 4 | 2012-05-01 | 2015-03-15 |
NCT02134405 | Dyspepsia | Drug: Rebamipide|Drug: Placebo (for Esomeprazole)|Drug: Esomeprazole | University of Malaya|Zhejiang Provincial Hospital of TCM|Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 4 | 2014-08-01 | 2016-01-04 |
NCT01759108 | Improving Symptoms of Dry Mouth in Sjgren's Syndrome | Drug: Rebamipide | Faculty of Medicine, University of Alexandria | 2012-12-01 | 2012-12-23 | |
NCT00641004 | NSAID Induced Gastropathy | Drug: Rebamipide and Esomeprazole | Otsuka Pharmaceutical, Inc., Philippines | Phase 4 | 2008-04-01 | 2011-08-23 |
NCT00201981 | Keratoconjunctivitis Sicca | Drug: Rebamipide | Otsuka Pharmaceutical Development & Commercialization, Inc.|Novartis | Phase 3 | 2004-05-01 | 2008-01-04 |
NCT02632812 | Gastrointestinal Lesions | Drug: Rebamipide effervescent granules|Drug: Placebo effervescent granules|Drug: Naproxen tablet | Biolab Sanus Farmaceutica | Phase 1 | 2014-10-01 | 2017-01-31 |
NCT02106130 | Healthy | Drug: Rebamipide|Drug: Mosapride citrate | IlDong Pharmaceutical Co Ltd | Phase 1 | 2013-05-01 | 2014-04-03 |
NCT01549743 | Healthy Male Volunteers | Drug: Celecoxib|Drug: Rebamipide|Drug: Celecoxib plus Rebamipide | Hanlim Pharm. Co., Ltd. | Phase 1 | 2012-05-01 | 2012-03-08 |
NCT01660256 | Dry Eye | Drug: OPC-12759|Drug: Placebo | Otsuka Pharmaceutical Co., Ltd. | Phase 3 | 2012-08-01 | 2013-06-09 |
NCT00201955 | Keratoconjunctivitis Sicca | Drug: Rebamipide | Otsuka Pharmaceutical Development & Commercialization, Inc.|Novartis | Phase 3 | 2004-05-01 | 2006-10-31 |
NCT01632137 | Dry Eye Syndrome | Drug: Rebamipide 2% ophthalmic suspension|Drug: Placebo (vehicle) | Acucela Inc.|Otsuka Pharmaceutical Co., Ltd. | Phase 3 | 2012-06-01 | 2014-04-17 |
NCT00233389 | Stomach Ulcer | Drug: Rebamipide | Otsuka Pharmaceutical Co., Ltd. | Phase 4 | 2004-01-01 | 2007-05-25 |
NCT02085460 | Head and Neck Cancer | Drug: Placebo|Drug: 2% Rebamipide liquid|Drug: 4% Rebamipide liquid | Otsuka Pharmaceutical Co., Ltd. | Phase 2 | 2014-03-01 | 2016-04-28 |
NCT01027013 | Dry Eye Syndromes|Keratoconjunctivitis Sicca | Drug: rebamipide 2% ophthalmic suspension|Drug: placebo eye drops | Acucela Inc.|Otsuka Pharmaceutical Co., Ltd. | Phase 2 | 2009-12-01 | 2012-01-09 |
NCT01057147 | Keratoconjunctivitis Sicca|Dry Eye | Drug: rebamipide 2% ophthalmic suspension|Drug: placebo eye drops | Acucela Inc.|Otsuka Pharmaceutical Co., Ltd. | Phase 2 | 2010-02-01 | 2012-01-09 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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