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Rebamipide

瑞巴派特,OPC-12759,Mucosta,OPC12759,Proamipide,OPC 12759,Rebagen

Rebamipide是内源性前列腺素诱导剂,同时是自由基清除剂。

目录号
EY1259
EY1259
纯度
99.54%
99.54%
规格
500 mg
1 g
原价
350
480
售价
350
480
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Rebamipide is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Iinuma, S., et al. 1998. Dig Dis Sci. 43: 35S-39S. PMID: 9753224
    [2] Otsubo, K., et al. 1991. Chem Pharm Bull. 39: 2906-2909. PMID: 1666022

    分子式
    C19H15ClN2O4
    分子量
    370.79
    CAS号
    90098-04-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    74 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00996788 Dyspepsia|Chronic Gastritis Drug: Rebamipide PT Otsuka Indonesia Phase 3 2007-10-01 2013-05-14
    NCT00997789 Therapeutic Equivalency|Pharmacogenetics Drug: Rebamide Chonnam National University Hospital|Institute of Bioequivalence and Bridging Study, College of Pharmacy, CNU 2008-03-01 2009-10-18
    NCT01167101 Stomach Ulcer Drug: Rebamipide|Drug: pantoprazole Kangdong Sacred Heart Hospital 2009-05-01 2015-09-03
    NCT00463151 Colitis, Ulcerative Drug: rebamipide Otsuka Pharmaceutical Co., Ltd. Phase 2 2007-06-01 2011-02-09
    NCT00272467 Stomach Ulcer Drug: Rebamipide|Drug: Omeprazole Korea Otsuka International Asia Arab|Zhejiang Otsuka Pharmaceutical Co., Ltd.|Korea Otsuka Pharmaceutical Co., Ltd. Phase 4 2005-07-01 2015-04-27
    NCT02755753 Gastroesophageal Reflux Drug: Lansoprazole|Drug: Rebamipide|Drug: Rebamipide-placebo YongChan Lee|Otsuka Pharmaceutical Co., Ltd.|Severance Hospital Phase 4 2014-01-01 2016-04-26
    NCT02393430 Gastritis Drug: Rebamipide|Behavioral: optimization of life style BangMao Wang|Tianjin Medical University General Hospital Phase 4 2012-05-01 2015-03-15
    NCT02134405 Dyspepsia Drug: Rebamipide|Drug: Placebo (for Esomeprazole)|Drug: Esomeprazole University of Malaya|Zhejiang Provincial Hospital of TCM|Second Affiliated Hospital, School of Medicine, Zhejiang University Phase 4 2014-08-01 2016-01-04
    NCT01759108 Improving Symptoms of Dry Mouth in Sjgren's Syndrome Drug: Rebamipide Faculty of Medicine, University of Alexandria 2012-12-01 2012-12-23
    NCT00641004 NSAID Induced Gastropathy Drug: Rebamipide and Esomeprazole Otsuka Pharmaceutical, Inc., Philippines Phase 4 2008-04-01 2011-08-23
    NCT00201981 Keratoconjunctivitis Sicca Drug: Rebamipide Otsuka Pharmaceutical Development & Commercialization, Inc.|Novartis Phase 3 2004-05-01 2008-01-04
    NCT02632812 Gastrointestinal Lesions Drug: Rebamipide effervescent granules|Drug: Placebo effervescent granules|Drug: Naproxen tablet Biolab Sanus Farmaceutica Phase 1 2014-10-01 2017-01-31
    NCT02106130 Healthy Drug: Rebamipide|Drug: Mosapride citrate IlDong Pharmaceutical Co Ltd Phase 1 2013-05-01 2014-04-03
    NCT01549743 Healthy Male Volunteers Drug: Celecoxib|Drug: Rebamipide|Drug: Celecoxib plus Rebamipide Hanlim Pharm. Co., Ltd. Phase 1 2012-05-01 2012-03-08
    NCT01660256 Dry Eye Drug: OPC-12759|Drug: Placebo Otsuka Pharmaceutical Co., Ltd. Phase 3 2012-08-01 2013-06-09
    NCT00201955 Keratoconjunctivitis Sicca Drug: Rebamipide Otsuka Pharmaceutical Development & Commercialization, Inc.|Novartis Phase 3 2004-05-01 2006-10-31
    NCT01632137 Dry Eye Syndrome Drug: Rebamipide 2% ophthalmic suspension|Drug: Placebo (vehicle) Acucela Inc.|Otsuka Pharmaceutical Co., Ltd. Phase 3 2012-06-01 2014-04-17
    NCT00233389 Stomach Ulcer Drug: Rebamipide Otsuka Pharmaceutical Co., Ltd. Phase 4 2004-01-01 2007-05-25
    NCT02085460 Head and Neck Cancer Drug: Placebo|Drug: 2% Rebamipide liquid|Drug: 4% Rebamipide liquid Otsuka Pharmaceutical Co., Ltd. Phase 2 2014-03-01 2016-04-28
    NCT01027013 Dry Eye Syndromes|Keratoconjunctivitis Sicca Drug: rebamipide 2% ophthalmic suspension|Drug: placebo eye drops Acucela Inc.|Otsuka Pharmaceutical Co., Ltd. Phase 2 2009-12-01 2012-01-09
    NCT01057147 Keratoconjunctivitis Sicca|Dry Eye Drug: rebamipide 2% ophthalmic suspension|Drug: placebo eye drops Acucela Inc.|Otsuka Pharmaceutical Co., Ltd. Phase 2 2010-02-01 2012-01-09

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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