Betaxolol hydrochloride是β1肾上腺素受体阻断剂,可作用于高血压和青光眼。
Betaxolol is a β1 adrenergic receptor blocker with IC50 of 6 μM.
100 μM
2.5 mg/kg 腹腔注射
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Tang LQ, et al. Curr Eye Res, 1998, 17(1), 24-30.
分子式 C18H30ClNO3 |
分子量 343.89 |
CAS号 63659-19-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 200 mM |
Water 200 mM |
Ethanol 200 mM |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01660620 | Development of Side Effects From Betaxolol | Drug: Betaxolol|Drug: topical betaxolol | Smith-Kettlewell Eye Research Institute|Ohio State University|University of Minnesota - Clinical and Translational Science Institute|University of Oklahoma|The University of Texas Health Science Center, Houston | Phase 1 | 2011-04-01 | 2013-01-02 |
NCT00061542 | Glaucoma|Ocular Hypertension | Drug: BETOPTIC S (betaxolol HCl)|Drug: Timolol Gel-forming Solution (TGFS) | Alcon Research | Phase 3 | 2003-01-01 | 2016-11-16 |
NCT02617459 | Primary Open-angle Glaucoma|Ocular Hypertension | Drug: Levobetaxolol eye drops|Drug: Betaxolol eye drops | Lee's Pharmaceutical Limited | Phase 3 | 2015-11-01 | 2015-11-30 |
NCT00000132 | Open-Angle Glaucoma | Drug: Betaxolol|Procedure: Argon Laser Trabeculoplasty | National Eye Institute (NEI) | Phase 3 | 1992-10-01 | 2005-06-23 |
NCT00684489 | Hypertension | Drug: clinical hypertension specialist-no specific med. Any anti-hypertension meds.|Drug: renin guided therapeutics-no specific med. Any anti-hypertensive med. | Medical University of South Carolina|New York Presbyterian Hospital | 2003-09-01 | 2008-05-22 | |
NCT01316952 | Hypersensitivity | Drug: Carvedilol immediate release only|Drug: Carvedilol extended release only|Drug: Long acting blockers|Drug: Other adrenergic antagonists|Drug: Short acting Non-selective blockers and short acting 1-Selective agents|Other: No blocker | GlaxoSmithKline | 2010-06-01 | 2015-04-14 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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