Gentamicin Sulfate是一种广谱的氨基糖苷类抗生素,用于细胞培养,抑制敏感机体的蛋白合成。
Gentamycin Sulfate is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Martin NL, et al. Antimicrob Agents Chemother. 1986 Jun;29(6):1079-87.
分子式 C21H43N5O7.H2SO4 |
分子量 575.67 |
CAS号 1405-41-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water 100 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01287780 | Surgical Wound Infection | Device: Collagen-gentamicin sponge | Oslo University Hospital | Phase 3 | 2011-01-01 | 2013-08-15 |
NCT01884467 | Urinary Tract Infections | Drug: Gentamicin|Drug: Placebo | Gillette Children's Specialty Healthcare | Phase 4 | 2013-05-01 | 2015-04-08 |
NCT02379754 | Vestibular Schwannoma | Drug: Gentamicins | Lund University | Phase 4 | 2015-01-01 | 2016-09-06 |
NCT00751374 | Rate of Exit Site Infection|Rate of Atypical Mycobacterial Infection|Rate of Peritoneal Dialysis | Drug: gentamicin|Drug: gentamicin cream alternating with mupirocin cream | Kwong Wah Hospital|The Hong Kong Society of Nephrology | Phase 4 | 2008-09-01 | 2008-09-10 |
NCT00451074 | Duchenne Muscular Dystrophy | Drug: Gentamicin infusions twice a week for six months | Nationwide Children's Hospital|National Institutes of Health (NIH)|National Institute of Neurological Disorders and Stroke (NINDS) | Phase 1 | 2007-03-01 | 2012-03-22 |
NCT02427932 | Drug Metabolism During Pregnancy | Drug: Ampicillin|Drug: Ampicillin and Gentamicin|Drug: Gentamicin | Stanford University|David Drover, MD | Phase 4 | 2015-05-01 | 2015-11-10 |
NCT01148693 | Cholangitis | Drug: gentamicin|Drug: Placebo | Tehran University of Medical Sciences | 2009-12-01 | 2011-09-18 | |
NCT02479971 | Pain | Drug: Clindamycin-gentamicin irrigation|Drug: Normal saline irrigation | Hospital General Universitario Elche | Phase 3 | 2014-01-01 | 2015-06-22 |
NCT00185991 | Chorioamnionitis | Drug: gentamicin | Stanford University | 2004-06-01 | 2011-06-13 | |
NCT02415257 | Vestibular Schwannoma | Drug: Gentamicin | Lund University | Phase 4 | 2015-04-01 | 2016-09-06 |
NCT00977405 | Superficial Surgical Site Infection | Device: Collatamp Gentamicin Implant | Singapore General Hospital|Novem Healthcare Pte Ltd | Phase 2 | 2009-09-01 | 2009-09-14 |
NCT02582099 | Rhinosinusitis | Drug: Gentamicin nasal irrigation|Drug: Normal saline nasal irrigation | Mahidol University | Phase 4 | 2013-12-01 | 2016-05-02 |
NCT03012191 | Recessive Dystrophic Epidermolysis Bullosa | Drug: Gentamicin Sulfate | University of Southern California | Phase 1|Phase 2 | 2017-01-01 | 2017-01-05 |
NCT01244256 | Folliculitis | Drug: Clotrimazole + Gentamicin + Beclomethasone|Drug: Clotrimazole + Gentamicin | Azidus Brasil | Phase 2|Phase 3 | 2007-04-01 | 2010-11-18 |
NCT01951768 | Diabetic Foot Ulcer | Drug: Garamycin Sponge (Gentamicin-Collagen sponge)|Drug: Systemic Antibiotic | University Hospital, Geneva | Phase 4 | 2013-09-01 | 2013-09-30 |
NCT02898961 | Sepsis | Drug: 30 mg/kg amikacin or 8 mg/kg gentamicin | Centre Hospitalier Universitaire de Nmes | Phase 4 | 2014-10-01 | 2017-02-02 |
NCT02447172 | Foot Ulcer, Diabetic|Infection | Drug: Gentamicin Collagen sponge|Other: Placebo | Innocoll | Phase 3 | 2015-06-01 | 2016-06-07 |
NCT02427802 | Foot Ulcer, Diabetic|Infection | Drug: Gentamicin collagen sponge|Other: Placebo | Innocoll | Phase 3 | 2015-05-01 | 2016-06-07 |
NCT01700504 | Axillary Drainage Volume After Lymph Node Dissection. | Drug: Axillary lavage with gentamicin solution | Hospital General Universitario Elche | Phase 3 | 2011-05-01 | 2012-10-02 |
NCT02314806 | Breast Cancer | Drug: Irrigation with gentamicin solution|Drug: Irrigation with Clindamycin solution|Drug: Irrigation with Normal saline | Hospital General Universitario Elche | Phase 3 | 2013-01-01 | 2014-12-09 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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