Pamidronate二钠盐可强化骨骼。
Pamidronate Disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Viereck V, et al. Biochem Biophys Res Commun,?002, 291(3), 680-686.
分子式 C3H9NNa4O7P2+2 |
分子量 325.01 |
CAS号 57248-88-1 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water 40 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02007915 | Femoral Head Avascular Necrosis | Drug: Pamidronate Disodium | The Hospital for Sick Children | 2009-07-01 | 2013-12-05 | |
NCT02544659 | SAPHO Syndrome | Drug: pamidronate disodium | Peking Union Medical College Hospital | Phase 1 | 2015-10-01 | 2016-10-12 |
NCT00657852 | Bone Disease, Metabolic | Drug: Disodium pamidronate|Drug: Placebo | Hospital Clinic of Barcelona|Novartis | Phase 4 | 2000-12-01 | 2008-04-08 |
NCT00124605 | Refractory Multiple Myeloma|Unspecified Adult Solid Tumor, Protocol Specific | Drug: pamidronate disodium|Drug: arsenic trioxide|Other: laboratory biomarker analysis|Other: pharmacological study | National Cancer Institute (NCI) | Phase 1 | 2005-04-01 | 2013-01-04 |
NCT00262392 | Heterotopic Ossification | Drug: Pamidronate (AREDIA) | University Hospital, Basel, Switzerland|FAG (Freie Medizinische Gesellschaft) | 2005-06-01 | 2015-03-09 | |
NCT00005901 | Osteogenesis Imperfecta | Drug: Pamidronate (Aredia) | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) | Phase 3 | 2000-06-01 | 2016-02-01 |
NCT02594878 | Immune System Disease|Musculoskeletal Disease | Drug: Pamidronatdinatrium|Other: Natrium chloride 9mg/ml | University of Aarhus | Phase 2 | 2015-10-01 | 2016-11-15 |
NCT00655681 | Osteoporosis|Cerebral Palsy|Spina Bifida|Osteopenia|Osteogenesis Imperfecta | Drug: pamidronate|Other: saline | University of New Mexico|Thrasher Research Fund | 2007-09-01 | 2012-02-29 | |
NCT02101164 | Solid Tumor|Metastatic Bone Disease | Biological: denosumab|Drug: pamidronate | Amgen | Phase 4 | 2014-11-01 | 2015-02-16 |
NCT02074631 | Osteopenia|Osteoporosis | Drug: Pamidronate|Drug: Calcium and vitamin D | Masonic Cancer Center, University of Minnesota | Phase 2 | 2015-02-01 | 2017-02-17 |
NCT01907880 | Breast Cancer | Drug: Pamidronate|Drug: Zoledronic acid|Drug: placebo | Ottawa Hospital Research Institute|Canadian Breast Cancer Foundation | Phase 4 | 2012-08-01 | 2016-09-15 |
NCT00033332 | Multiple Myeloma and Plasma Cell Neoplasm | Drug: dexamethasone|Drug: pamidronate disodium|Drug: thalidomide|Drug: zoledronic acid | National Cancer Institute (NCI) | Phase 3 | 2002-04-01 | 2014-04-02 |
NCT02721433 | Breast Cancer|Prostate Cancer|Metastasis | Drug: Pamidronate|Drug: Denosumab|Drug: Zoledronate | Ottawa Hospital Research Institute | Phase 4 | 2016-08-01 | 2016-09-27 |
NCT00482378 | Multiple Myeloma and Plasma Cell Neoplasm|Pain | Drug: Pamidronate|Drug: Zoledronic acid|Radiation: Sm 153 lexidronam | Mayo Clinic|National Cancer Institute (NCI) | Phase 1|Phase 2 | 2005-03-01 | 2016-10-10 |
NCT00582920 | Osseous Lesions From Metastatic Breast Cancer | Radiation: Zometa,Memorial Sloan Kettering Cancer Center" | Female | 2008-10-01 | 2015-12-01 | |
NCT00062595 | Osteoporosis | Drug: phylloquinone (K1)|Drug: menatetranone (MK4) | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Eisai Co., Ltd. | Phase 3 | 2000-09-01 | 2016-05-16 |
NCT00088309 | HIV Infections | Procedure: Eye exam|Procedure: Oral exam|Procedure: CT scan|Procedure: Neuropsychological testing|Procedure: Electrocardiogram|Procedure: Echocardiogram | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2004-06-01 | 2008-03-03 |
NCT00004088 | Multiple Myeloma and Plasma Cell Neoplasm | Biological: filgrastim|Biological: recombinant interferon alfa|Drug: busulfan|Drug: cyclophosphamide|Drug: melphalan|Drug: pamidronate disodium|Drug: thalidomide|Procedure: peripheral blood stem cell transplantation | City of Hope Medical Center|National Cancer Institute (NCI) | Phase 2 | 1999-04-13 | 2017-03-01 |
NCT00004906 | Breast Cancer | Biological: filgrastim|Drug: anastrozole|Drug: carboplatin|Drug: cisplatin|Drug: cyclophosphamide|Drug: docetaxel|Drug: doxorubicin hydrochloride|Drug: etoposide|Drug: pamidronate disodium|Drug: thiotepa|Procedure: peripheral blood stem cell transplantation | Hackensack University Medical Center|National Cancer Institute (NCI) | Phase 2 | 1999-10-01 | 2013-05-29 |
NCT00083408 | Multiple Myeloma | Drug: Pamidronate|Drug: Thalidomide | University of Arkansas | Phase 2 | 1998-03-01 | 2010-07-01 |
NCT00083382 | Multiple Myeloma | Drug: Pamidronate|Drug: Thalidomide|Drug: Zometa | University of Arkansas | Phase 2 | 1998-12-01 | 2015-06-05 |
NCT01875458 | Osteoporosis, With or Without Treatment|Bisphosphonate Treatment|Atypical Femur Fracture|Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ)|Healthy Volunteers | University of Pennsylvania | 2013-05-01 | 2016-05-03 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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