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Pamidronate Disodium

帕米磷酸二钠,CGP 23339AE,CGP23339AE,CGP-23339AE

Pamidronate二钠盐可强化骨骼。

目录号
EY1241
EY1241
纯度
99.25%
99.25%
规格
50 mg
250 mg
原价
350_
780
售价
350_
780
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Pamidronate Disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Viereck V, et al. Biochem Biophys Res Commun,?002, 291(3), 680-686.

    分子式
    C3H9NNa4O7P2+2
    分子量
    325.01
    CAS号
    57248-88-1
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    40 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02007915 Femoral Head Avascular Necrosis Drug: Pamidronate Disodium The Hospital for Sick Children 2009-07-01 2013-12-05
    NCT02544659 SAPHO Syndrome Drug: pamidronate disodium Peking Union Medical College Hospital Phase 1 2015-10-01 2016-10-12
    NCT00657852 Bone Disease, Metabolic Drug: Disodium pamidronate|Drug: Placebo Hospital Clinic of Barcelona|Novartis Phase 4 2000-12-01 2008-04-08
    NCT00124605 Refractory Multiple Myeloma|Unspecified Adult Solid Tumor, Protocol Specific Drug: pamidronate disodium|Drug: arsenic trioxide|Other: laboratory biomarker analysis|Other: pharmacological study National Cancer Institute (NCI) Phase 1 2005-04-01 2013-01-04
    NCT00262392 Heterotopic Ossification Drug: Pamidronate (AREDIA) University Hospital, Basel, Switzerland|FAG (Freie Medizinische Gesellschaft) 2005-06-01 2015-03-09
    NCT00005901 Osteogenesis Imperfecta Drug: Pamidronate (Aredia) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) Phase 3 2000-06-01 2016-02-01
    NCT02594878 Immune System Disease|Musculoskeletal Disease Drug: Pamidronatdinatrium|Other: Natrium chloride 9mg/ml University of Aarhus Phase 2 2015-10-01 2016-11-15
    NCT00655681 Osteoporosis|Cerebral Palsy|Spina Bifida|Osteopenia|Osteogenesis Imperfecta Drug: pamidronate|Other: saline University of New Mexico|Thrasher Research Fund 2007-09-01 2012-02-29
    NCT02101164 Solid Tumor|Metastatic Bone Disease Biological: denosumab|Drug: pamidronate Amgen Phase 4 2014-11-01 2015-02-16
    NCT02074631 Osteopenia|Osteoporosis Drug: Pamidronate|Drug: Calcium and vitamin D Masonic Cancer Center, University of Minnesota Phase 2 2015-02-01 2017-02-17
    NCT01907880 Breast Cancer Drug: Pamidronate|Drug: Zoledronic acid|Drug: placebo Ottawa Hospital Research Institute|Canadian Breast Cancer Foundation Phase 4 2012-08-01 2016-09-15
    NCT00033332 Multiple Myeloma and Plasma Cell Neoplasm Drug: dexamethasone|Drug: pamidronate disodium|Drug: thalidomide|Drug: zoledronic acid National Cancer Institute (NCI) Phase 3 2002-04-01 2014-04-02
    NCT02721433 Breast Cancer|Prostate Cancer|Metastasis Drug: Pamidronate|Drug: Denosumab|Drug: Zoledronate Ottawa Hospital Research Institute Phase 4 2016-08-01 2016-09-27
    NCT00482378 Multiple Myeloma and Plasma Cell Neoplasm|Pain Drug: Pamidronate|Drug: Zoledronic acid|Radiation: Sm 153 lexidronam Mayo Clinic|National Cancer Institute (NCI) Phase 1|Phase 2 2005-03-01 2016-10-10
    NCT00582920 Osseous Lesions From Metastatic Breast Cancer Radiation: Zometa,Memorial Sloan Kettering Cancer Center" Female 2008-10-01 2015-12-01
    NCT00062595 Osteoporosis Drug: phylloquinone (K1)|Drug: menatetranone (MK4) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Eisai Co., Ltd. Phase 3 2000-09-01 2016-05-16
    NCT00088309 HIV Infections Procedure: Eye exam|Procedure: Oral exam|Procedure: CT scan|Procedure: Neuropsychological testing|Procedure: Electrocardiogram|Procedure: Echocardiogram National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Phase 2 2004-06-01 2008-03-03
    NCT00004088 Multiple Myeloma and Plasma Cell Neoplasm Biological: filgrastim|Biological: recombinant interferon alfa|Drug: busulfan|Drug: cyclophosphamide|Drug: melphalan|Drug: pamidronate disodium|Drug: thalidomide|Procedure: peripheral blood stem cell transplantation City of Hope Medical Center|National Cancer Institute (NCI) Phase 2 1999-04-13 2017-03-01
    NCT00004906 Breast Cancer Biological: filgrastim|Drug: anastrozole|Drug: carboplatin|Drug: cisplatin|Drug: cyclophosphamide|Drug: docetaxel|Drug: doxorubicin hydrochloride|Drug: etoposide|Drug: pamidronate disodium|Drug: thiotepa|Procedure: peripheral blood stem cell transplantation Hackensack University Medical Center|National Cancer Institute (NCI) Phase 2 1999-10-01 2013-05-29
    NCT00083408 Multiple Myeloma Drug: Pamidronate|Drug: Thalidomide University of Arkansas Phase 2 1998-03-01 2010-07-01
    NCT00083382 Multiple Myeloma Drug: Pamidronate|Drug: Thalidomide|Drug: Zometa University of Arkansas Phase 2 1998-12-01 2015-06-05
    NCT01875458 Osteoporosis, With or Without Treatment|Bisphosphonate Treatment|Atypical Femur Fracture|Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ)|Healthy Volunteers University of Pennsylvania 2013-05-01 2016-05-03

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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