Nystatin是多烯类抗真菌抗生素,对酵母和支原体有效。
Nystatin, which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Brautaset, T., et al.: Chem. Biol., 7, 395 (2000), Brautaset, T., et al.: J. Biol. Chem., 278, 14913 (2003), Bruheim, P., et al.: Antimicrob. Agents Chemother., 48, 4120
分子式 C47H75NO17 |
分子量 926.09 |
CAS号 1400-61-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 20 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01198223 | Denture Stomatitis | Drug: garlic , nystatin | Qazvin University Of Medical Sciences | Phase 2 | 2010-07-01 | 2010-10-15 |
NCT01495039 | Fungal Prophylaxis|Candida Infection|Critical Illness|Surgery | Drug: Nystatin | Policlinico Hospital | Phase 4 | 2008-11-01 | 2011-12-16 |
NCT01427738 | HIV-1 Infection | Drug: Gentian Violet|Drug: Nystatin oral suspension | AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 | 2011-06-01 | 2015-02-12 |
NCT00002097 | HIV Infections | Drug: Nystatin | Argus Pharmaceuticals|NIH AIDS Clinical Trials Information Service | Phase 1 | | 2005-06-23 |
NCT00001998 | HIV Infections | Drug: Nystatin | Argus Pharmaceuticals|NIH AIDS Clinical Trials Information Service | | 2005-06-23 | |
NCT02186145 | Bacterial Vaginosis|Fungal Vaginal Infections | Drug: Association of metronidazole; nystatin and dexamethasone|Drug: Flagyl | Marjan Industria e Comercio ltda | Phase 3 | 2016-01-01 | 2015-04-08 |
NCT00002057 | Candidiasis, Oral|HIV Infections | Drug: Nystatin | Bristol-Myers Squibb | | 2007-10-01 | |
NCT00002293 | Candidiasis, Oral|HIV Infections | Drug: Nystatin | Bristol-Myers Squibb | | 2007-10-01 | |
NCT02642900 | Photochemotherapy Reaction | Procedure: Photodynamic Therapy|Drug: Nystatin 100.000 units | University of Sao Paulo | Phase 4 | 2009-07-01 | 2015-12-25 |
NCT00002313 | HIV Infections | Drug: Nystatin|Drug: Didanosine | Argus Pharmaceuticals|NIH AIDS Clinical Trials Information Service | Phase 1 | | 2005-06-23 |
NCT00001812 | Candidiasis, Oral|Gastrointestinal Diseases|Stomatitis | Drug: Nystatin | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) | Phase 3 | 1999-04-01 | 2008-03-03 |
NCT00002112 | Candidiasis, Oral|HIV Infections | Drug: Nystatin|Drug: Fluconazole | Pfizer|NIH AIDS Clinical Trials Information Service | | 2005-06-23 | |
NCT01531192 | Very Low Birth Weight Infants | Dietary Supplement: Lactobacillus reuteri|Drug: Nystatin | Zekai Tahir Burak Women's Health Research and Education Hospital | Phase 4 | 2012-06-01 | 2013-07-13 |
NCT00128323 | Candidiasis, Oral | Drug: Gentian violet 1% solution|Drug: Gentian violet 0.00165% solution|Drug: Nystatin solution | University of Malawi College of Medicine|British Society for Antimicrobial Chemotherapy | Phase 3 | 2002-11-01 | 2008-02-07 |
NCT01867164 | Vaginitis|Infectious Vaginosis | Drug: Gynoclin V|Drug: Vagitrol V | Janssen-Cilag, S.A. | Phase 3 | 2007-12-01 | 2013-11-01 |
NCT01718912 | Periodontal Disease | Drug: metronidazole-nystatin oral rinse | Oravital Inc | 2013-11-01 | 2016-03-29 | |
NCT00002742 | Chronic Myeloproliferative Disorders|Infection|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes | Drug: amphotericin B deoxycholate|Drug: nystatin | Aronex Pharmaceuticals|National Cancer Institute (NCI) | Phase 3 | 1996-01-01 | 2013-03-25 |
NCT01411748 | Anticandidal Property of Saccharomyces Boulardii on Very Low Birth Weight Infants | Dietary Supplement: Reflor|Drug: mikostatin | Zekai Tahir Burak Women's Health Research and Education Hospital | Phase 4 | 2011-07-01 | 2011-08-05 |
NCT01798537 | Bacteremia Associated With Intravascular Line|Ventilator Associated Pneumonia|Bacteremia | Drug: Neomycin Colistin Nystatin Vancomycin | Rambam Health Care Campus | Phase 2|Phase 3 | 2013-06-01 | 2013-02-25 |
NCT00250133 | VRE Colonization | Procedure: Blood draws | University of Pittsburgh | Phase 3 | | 2007-08-31 |
NCT02166450 | Denture Stomatitis | Drug: Nystatin | Jagiellonian University | 2011-10-01 | 2014-06-18 | |
NCT00629122 | Kidney Failure, Chronic | Drug: Tacrolimus/Clotrimazole Troche|Drug: Tacrolimus/Nystatin Suspension | Weill Medical College of Cornell University | Phase 4 | 2008-02-01 | 2010-11-04 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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