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AZD2014

Vistusertib

AZD2014是高效mTOR抑制剂,IC50为2.8 nM,对PI3K各亚型(α/β/γ/δ)的抑制性较弱。

目录号
EY1214
EY1214
EY1214
纯度
99.23%
99.23%
99.23%
规格
1 mg
5 mg
50 mg
原价
280
670
2800
售价
280
670
2800
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    AZD2014 is a novel mTOR inhibitor with IC50 of 2.8 nM in a cell-free assay; highly selective against multiple PI3K isoforms (α/β/γ/δ). Phase 2.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Sylvie M, et al, AACR Annual Meeting, 2012, Abst 917.

    分子式
    C25H30N6O3
    分子量
    462.54
    CAS号
    1009298-59-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    35 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT03061708 Stomach Neoplasms Drug: AZD2014 Samsung Medical Center Phase 2 2017-02-01 2017-02-21
    NCT02193633 Advanced Cancer Drug: AZD2014 3 on/4 off & weekly paclitaxel|Drug: AZD2014 2 on/5 off & weekly paclitaxel Royal Marsden NHS Foundation Trust|Institute of Cancer Research, United Kingdom|AstraZeneca Phase 1 2013-04-01 2015-03-11
    NCT02064608 Prostate Cancer Drug: AZD2014 Cambridge University Hospitals NHS Foundation Trust|AstraZeneca Phase 1 2014-10-01 2017-01-06
    NCT01597388 Advanced Metastatic Breast Cancer Drug: AZD2014|Drug: Fulvestrant AstraZeneca Phase 1 2012-05-01 2017-01-23
    NCT02619864 Glioblastoma Multiforme Drug: AZD2014 Canadian Cancer Trials Group|AstraZeneca Phase 1|Phase 2 2015-11-01 2017-03-13
    NCT02780830 Core: Relapsed or Refractory Diffuse Large B-Cell Lymphoma|Module 1: Non-GCB Diffuse Large B-Cell Lymphoma Drug: AZD2014|Drug: Ibrutinib AstraZeneca Phase 1 2016-06-01 2016-09-14
    NCT01026402 Advanced Solid Malignancies Drug: AZD2014 AstraZeneca Phase 1 2009-12-01 2016-01-13
    NCT01793636 Metastatic Clear Cell Renal Carcinoma Drug: AZD2014|Drug: Everolimus Queen Mary University of London|AstraZeneca|Cancer Research UK Phase 2 2013-02-01 2014-06-23
    NCT03071874 Meningioma Drug: AZD2014 Massachusetts General Hospital|National Cancer Institute (NCI)|AstraZeneca Phase 2 2017-03-15 2017-03-01
    NCT02208375 Breast Cancer|Malignant Female Reproductive System Neoplasm Drug: Olaparib|Drug: AZD2014|Drug: AZD5363 M.D. Anderson Cancer Center|AstraZeneca|National Cancer Institute (NCI) Phase 1|Phase 2 2014-11-01 2017-03-06
    NCT02831257 Neurofibromatosis 2|Meningioma Drug: AZD2014 Massachusetts General Hospital|AstraZeneca|United States Department of Defense Phase 2 2016-07-01 2016-09-25
    NCT02583542 Triple-Negative Breast Cancer|Squamous Cell Lung Cancer|Non-squamous Cell Lung Cancer With KRAS Mutations|Non-squamous Cell Lung Cancer With Wild-type KRAS Drug: AZD2014|Drug: AZD6244 Queen Mary University of London|Cancer Research UK|AstraZeneca Phase 1|Phase 2 2015-06-01 2015-10-20
    NCT02403895 Squamous Non Small Cell Lung Cancer Drug: Open-label AZD2014|Drug: paclitaxel AstraZeneca Phase 2 2015-04-01 2017-01-27
    NCT02398747 Advanced Solid Malignancies Drug: AZD2014 AstraZeneca Phase 1 2015-03-01 2017-02-27
    NCT03082833 Cancer of Stomach Drug: AZD2014 Samsung Medical Center Phase 2 2017-02-01 2017-03-12
    NCT02599714 Advanced and Metastatic Breast Cancer Drug: AZD2014|Drug: Placebo to match AZD2014|Drug: palbociclib|Drug: fulvestrant|Drug: Placebo to match palbociclib AstraZeneca|SCRI Development Innovations, LLC Phase 1|Phase 2 2015-12-01 2017-02-22
    NCT02752204 Diffuse Large B-Cell Lymphoma Drug: AZD 2014|Drug: Rituximab University of Birmingham|Bloodwise|AstraZeneca|Cancer Research UK Phase 2 2015-10-01 2017-02-03
    NCT02640755 Solid Malignancies Drug: [14C]AZD2014|Drug: Multiple dose AZD2014|Drug: Fulvestrant|Drug: Paclitaxel AstraZeneca|Quintiles, Inc. Phase 1 2016-01-01 2017-02-27
    NCT02216786 Estrogen Receptor Positive Breast Cancer Drug: AZD2014|Drug: Everolimus|Drug: Fulvestrant Queen Mary University of London|AstraZeneca Phase 2 2014-01-01 2015-01-23
    NCT02730923 Endometrial Carcinoma|Metastatic Carcinoma|Hormone Receptor Positive Tumor Drug: AZD2014|Drug: Anastrozole Centre Leon Berard Phase 1|Phase 2 2016-04-01 2016-11-02

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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