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Phenytoin

苯妥英,Diphenylhydantoin

Phenytoin是一种失活的电压门控钠离子通道稳定剂。

目录号
EY1207
EY1207
EY1207
纯度
99.54%
99.54%
99.54%
规格
500 mg
1 g
5 g
原价
320
442
850
售价
320
442
850
库存
现货
现货
现货
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  • 生物活性

    Phenytoin is an inactive voltage-gated sodium channel stabilizer.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Ji Hyun Yi et. Al. Genetic Variations of ABCC2 Gene Associated with Adverse Drug Reactions to Valproic Acid in Korean Epileptic Patients. Genomics & Informatics, 11(4), 254-262 (2013).
    [2] Yasuo Uchida et. Al. Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models. Drug Metabolism and Disposition, 42(10), 1719-1726 (2014).
    [3] David S Paek et. Al. Metyrapone alleviates deleterious effects of maternal food restriction on lung development and growth of rat offspring. Reproductive Sciences, 22(2), 207-222 (2015).

    分子式
    C15H12N2O2    		 分子量
    252.27    		 CAS号
    57-41-0    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    50 mg/mL     		Water
    <1 mg/mL    		 Ethanol
    12 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00581893 Cognitive Measures|Driving Simulator Performance Drug: Phenytoin University of Iowa Phase 4 2005-08-01 2007-12-27
    NCT02413658 Wound|Re-Epithelialization Drug: Phenytoin|Drug: Sugar solution Children's Surgical Center, Cambodia Phase 2 2015-03-01 2015-04-09
    NCT02409433 Seizures Drug: lacosamide|Drug: Phenytoin Lawson Health Research Institute|UCB Pharma GmbH Phase 4 2014-08-01 2016-01-05
    NCT00823264 Phenytoin Toxicity Drug: Activated Charcoal Emory University 2008-08-01 2014-09-04
    NCT01122940 Healthy Drug: Epamin: Reference Drug|Drug: Phenytoin: Study Drug Pfizer Phase 1 2010-07-01 2011-01-13
    NCT01478035 Seizures|Pneumococcal Meningitis Drug: Phenytoin|Drug: placebo M. Carmen Cabellos Minguez|Hospital Universitari de Bellvitge|Hospital Vall d'Hebron|Germans Trias i Pujol Hospital|Hospital Clinic of Barcelona|Fundaci贸 Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau|Hospitales Universitarios Virgen del Roco|Hospital Universitario La Paz|Hospital Universitario Ramon y Cajal|Hospital Juan Canalejo|Hospital Mutua de Terrassa|Hospital Universitario Virgen Macarena Phase 4 2011-11-01 2012-12-19
    NCT01187719 HIV-infection|Pregnancy|Mother to Child Transmission Drug: phenytoin Radboud University Phase 2 2010-05-01 2012-09-17
    NCT01451593 Optic Neuritis|Multiple Sclerosis Drug: Phenytoin|Drug: Placebo University College, London|National Multiple Sclerosis Society|Multiple Sclerosis Society of Great Britain and Northern Ireland Phase 2 2011-11-01 2015-09-08
    NCT02939937 Optic Neuritis Drug: Phenytoin|Drug: placebo Tehran University of Medical Sciences Phase 2 2016-07-01 2016-10-18
    NCT01122953 Healthy Drug: Phenytoin|Drug: Epamin Pfizer Phase 1 2010-04-01 2010-07-15
    NCT02595723 Cognitive Impairment Drug: Phenytoin|Drug: Megestrol Acetate|Drug: Placebo University of Texas Southwestern Medical Center|The Rogosin Institute Early Phase 1 2015-07-01 2016-12-28
    NCT00146237 Depression Drug: phenytoin Beersheva Mental Health Center|The Rogosin Institute Phase 4 2003-11-01 2009-11-23
    NCT01680042 Wound Healing|Pain Drug: Phenytoin paste|Drug: Placebo Shahid Beheshti University of Medical Sciences Phase 1 2012-10-01 2012-10-01
    NCT02088957 Nonconvulsive Electrographic Seizures Drug: Brivaracetam intravenous solution|Drug: Brivaracetam oral tablets|Drug: Phenytoin intravenous solution|Drug: Phenytoin oral tablets UCB BIOSCIENCES, Inc.|PRA Health Sciences|UCB Pharma Phase 2 2014-03-01 2016-07-05
    NCT00366067 Bronchial Asthma Drug: Phenytoin Centre of Chinese Medicine, Georgia|Rea Rehabilitation Centre, Georgia Phase 4 2006-08-01 2009-02-18
    NCT00426673 Epilepsy Drug: Brivaracetam (ucb34714) UCB Pharma Phase 1 2005-04-01 2008-03-07
    NCT00591006 Healthy Drug: Phenytoin (brand name Dilantin)|Drug: Hydrocortisone|Drug: Placebo University of Texas Southwestern Medical Center Phase 3 2008-01-01 2015-08-12
    NCT00162461 Healthy Drug: Phenytoin single dose (300 mg) Hadassah Medical Organization|United States - Israel Binational Science Foundation 1998-08-01 2017-03-03
    NCT00647621 Healthy Drug: Extended Phenytoin Sodium Capsules 100 mg|Drug: DilantinKapseals 100 mg Mylan Pharmaceuticals Phase 1 2005-10-01 2008-03-31
    NCT00000285 Cocaine-Related Disorders Drug: Phenytoin National Institute on Drug Abuse (NIDA)|University of Minnesota - Clinical and Translational Science Institute Phase 1 1996-05-01 2017-01-11
    NCT01635829 Healthy Participants Drug: Telaprevir|Drug: Phenytoin|Drug: Carbamazepine Janssen Infectious Diseases BVBA Phase 1 2012-05-01 2013-10-23
    NCT00781196 Gingival Overgrowth Drug: folic acid|Drug: placebo All India Institute of Medical Sciences, New Delhi Phase 3 2008-05-01 2009-08-03
    NCT00219479 Seizures Drug: Phenytoin (Dilantin) levels during change in enteral feeding Penn State University Phase 4 1997-08-01 2008-06-13

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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