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Zonisamide

唑尼沙胺,唑利磺胺,佐尼沙胺,Excegran,excegram,CI-912

Zonisamide为1,2苯异恶唑衍生物,有抗癫痫活性。

目录号
EY1199
EY1199
纯度
99.62%
99.62%
规格
200 mg
500 mg
原价
780
1100
售价
780
1100
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Zonisamide is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Sonsalla PK, et al. Exp Neurol, 2010, 221(2), 329-334.

    分子式
    C8H8N2O3S
    分子量
    212.23
    CAS号
    68291-97-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    41 mg/mL
    Water
    <1 mg/mL
    Ethanol
    5 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00203450 Obesity Drug: Zonegran|Drug: Placebo Tuscaloosa Research & Education Advancement Corporation|Eisai Inc. Phase 4 2003-05-01 2012-08-30
    NCT01765608 Sleep Apnea|Obstructive Sleep Apnea|Obesity Drug: Zonisamide|Drug: Placebo|Device: nCPAP G枚teborg University|Eisai Inc. Phase 2 2010-03-01 2014-02-19
    NCT01161966 Healthy Drug: Zonisamide|Drug: Zonegran Dr. Reddy's Laboratories Limited Phase 1 2005-01-01 2010-07-13
    NCT01161979 Healthy Drug: Zonisamide|Drug: Zonegran Dr. Reddy's Laboratories Limited Phase 1 2005-01-01 2010-07-13
    NCT01685996 Nicotine Dependence Drug: zonisamide|Drug: placebo Johns Hopkins University Phase 1|Phase 2 2012-09-01 2014-01-29
    NCT01566370 Alcohol Use Disorders|Bipolar Disorder Drug: Zonisamide|Drug: Placebo Yale University|National Institute on Alcohol Abuse and Alcoholism (NIAAA) Phase 2 2012-05-01 2016-11-17
    NCT01766128 Parkinson Disease Drug: Zonisamide Mazandaran University of Medical Sciences Phase 2|Phase 3 2013-02-01 2013-01-09
    NCT00406692 Alcoholism Drug: Zonisamide Boston University Phase 2 2006-11-01 2010-05-06
    NCT00223743 Essential Tremor Drug: Zonisamide VA Greater Los Angeles Healthcare System|Ralph M. Parsons Foundation Phase 2 2004-11-01 2012-06-20
    NCT00685139 Healthy Drug: Zonisamide 100 mg Capsule|Drug: Zonisamide (Zonegran) 100 mg Capsule Mutual Pharmaceutical Company, Inc. Phase 1 2005-01-01 2010-01-11
    NCT00687167 Healthy Drug: Zonisamide 100 mg Capsule|Drug: Zonisamide (Zonegran) 100 mg Capsule Mutual Pharmaceutical Company, Inc. Phase 1 2005-01-01 2010-01-11
    NCT00616343 Essential Tremor Drug: Zonisamide Loma Linda University 2003-06-01 2014-07-16
    NCT01630057 Partial Seizures Drug: Adjunctive Zonisamide|Drug: Replacement with Zonisamide Eisai Inc. Phase 4 2009-09-01 2014-07-11
    NCT01283256 Partial, Generalized and Combined Seizures Drug: zonisamide Eisai Inc. Phase 4 2011-01-01 2014-01-23
    NCT02368431 Alcohol Use Disorder Drug: Zonisamide|Drug: Placebo VA Office of Research and Development Phase 3 2015-03-01 2016-09-21
    NCT00692003 Epilepsy Drug: Zonisamide|Drug: Placebo Eisai Limited|Eisai Inc. Phase 3 2008-08-01 2017-02-01
    NCT00275834 Obesity Drug: Zonisamide Duke University|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2006-01-01 2016-11-15
    NCT00566254 Epilepsy; Paediatric Partial Onset Seizures Drug: Zonisamide|Drug: Placebo Eisai Inc. Phase 3 2008-12-01 2013-05-09
    NCT00327717 Partial Seizures Drug: Zonisamide|Drug: Placebo Eisai Inc. Phase 3 2006-09-01 2014-08-14
    NCT00595556 Alcoholism|Alcohol Abuse|Alcohol Dependence Drug: zonisamide|Drug: Placebo UConn Health|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|National Center for Research Resources (NCRR) Phase 4 2006-07-01 2010-09-28

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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