Zonisamide为1,2苯异恶唑衍生物,有抗癫痫活性。
Zonisamide is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Sonsalla PK, et al. Exp Neurol, 2010, 221(2), 329-334.
分子式 C8H8N2O3S |
分子量 212.23 |
CAS号 68291-97-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 41 mg/mL |
Water <1 mg/mL |
Ethanol 5 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00203450 | Obesity | Drug: Zonegran|Drug: Placebo | Tuscaloosa Research & Education Advancement Corporation|Eisai Inc. | Phase 4 | 2003-05-01 | 2012-08-30 |
NCT01765608 | Sleep Apnea|Obstructive Sleep Apnea|Obesity | Drug: Zonisamide|Drug: Placebo|Device: nCPAP | G枚teborg University|Eisai Inc. | Phase 2 | 2010-03-01 | 2014-02-19 |
NCT01161966 | Healthy | Drug: Zonisamide|Drug: Zonegran | Dr. Reddy's Laboratories Limited | Phase 1 | 2005-01-01 | 2010-07-13 |
NCT01161979 | Healthy | Drug: Zonisamide|Drug: Zonegran | Dr. Reddy's Laboratories Limited | Phase 1 | 2005-01-01 | 2010-07-13 |
NCT01685996 | Nicotine Dependence | Drug: zonisamide|Drug: placebo | Johns Hopkins University | Phase 1|Phase 2 | 2012-09-01 | 2014-01-29 |
NCT01566370 | Alcohol Use Disorders|Bipolar Disorder | Drug: Zonisamide|Drug: Placebo | Yale University|National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Phase 2 | 2012-05-01 | 2016-11-17 |
NCT01766128 | Parkinson Disease | Drug: Zonisamide | Mazandaran University of Medical Sciences | Phase 2|Phase 3 | 2013-02-01 | 2013-01-09 |
NCT00406692 | Alcoholism | Drug: Zonisamide | Boston University | Phase 2 | 2006-11-01 | 2010-05-06 |
NCT00223743 | Essential Tremor | Drug: Zonisamide | VA Greater Los Angeles Healthcare System|Ralph M. Parsons Foundation | Phase 2 | 2004-11-01 | 2012-06-20 |
NCT00685139 | Healthy | Drug: Zonisamide 100 mg Capsule|Drug: Zonisamide (Zonegran) 100 mg Capsule | Mutual Pharmaceutical Company, Inc. | Phase 1 | 2005-01-01 | 2010-01-11 |
NCT00687167 | Healthy | Drug: Zonisamide 100 mg Capsule|Drug: Zonisamide (Zonegran) 100 mg Capsule | Mutual Pharmaceutical Company, Inc. | Phase 1 | 2005-01-01 | 2010-01-11 |
NCT00616343 | Essential Tremor | Drug: Zonisamide | Loma Linda University | 2003-06-01 | 2014-07-16 | |
NCT01630057 | Partial Seizures | Drug: Adjunctive Zonisamide|Drug: Replacement with Zonisamide | Eisai Inc. | Phase 4 | 2009-09-01 | 2014-07-11 |
NCT01283256 | Partial, Generalized and Combined Seizures | Drug: zonisamide | Eisai Inc. | Phase 4 | 2011-01-01 | 2014-01-23 |
NCT02368431 | Alcohol Use Disorder | Drug: Zonisamide|Drug: Placebo | VA Office of Research and Development | Phase 3 | 2015-03-01 | 2016-09-21 |
NCT00692003 | Epilepsy | Drug: Zonisamide|Drug: Placebo | Eisai Limited|Eisai Inc. | Phase 3 | 2008-08-01 | 2017-02-01 |
NCT00275834 | Obesity | Drug: Zonisamide | Duke University|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 2006-01-01 | 2016-11-15 | |
NCT00566254 | Epilepsy; Paediatric Partial Onset Seizures | Drug: Zonisamide|Drug: Placebo | Eisai Inc. | Phase 3 | 2008-12-01 | 2013-05-09 |
NCT00327717 | Partial Seizures | Drug: Zonisamide|Drug: Placebo | Eisai Inc. | Phase 3 | 2006-09-01 | 2014-08-14 |
NCT00595556 | Alcoholism|Alcohol Abuse|Alcohol Dependence | Drug: zonisamide|Drug: Placebo | UConn Health|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|National Center for Research Resources (NCRR) | Phase 4 | 2006-07-01 | 2010-09-28 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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