Home > Phosphodiesterase (PDE) & > Dipyridamole

Dipyridamole

双嘧达莫,NSC-515776,NSC 515776,NSC515776

Dipyridamole是磷酸二酯酶抑制剂，能阻断红细胞和血管内皮细胞对腺苷的吸收和代谢。

目录号
EY1197
EY1197
纯度
99.28%
99.28%
规格
100 mg
500 mg
原价
420
615
售价
420
615
库存
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Phedias Diamandis et. Al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nature Chemical Biology, 3(5), 268-273 (2007).
    [2] Terence B Beghyn et. Al. Drug to genome to drug: discovery of new antiplasmodial compounds. Journal of medicinal and pharmaceutical chemistry, 54(9), 3222-3240 (2011).

    分子式
    C24H40N8O4    		 分子量
    504.63    		 CAS号
    58-32-2    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    100 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    50 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02121756 HIV Infection Drug: Dipyridamole|Drug: Placebo, then Dipyridamole Sharon Riddler|National Institute of Allergy and Infectious Diseases (NIAID)|University of Pittsburgh Phase 1|Phase 2 2014-07-01 2017-02-02
    NCT00457405 Ischemia-Reperfusion Injury|Atherosclerosis Drug: dipyridamole Radboud University Phase 4 2007-06-01 2008-04-14
    NCT00906035 Peripheral Arterial Disease Drug: Dipyridamole 200mg and Aspirin 25mg bid:|Drug: Dipyridamole 200 mg bid|Drug: Aspirin 25 mg bid University of Pennsylvania|Boehringer Ingelheim 2002-09-01 2013-01-31
    NCT01295567 Cardiovascular Disease|Ischemic Heart Disease Drug: Dipyridamole|Drug: placebo Radboud University Phase 4 2009-12-01 2013-01-08
    NCT01613755 Diabetes Drug: Metformin, dipyridamole|Drug: Metformin Radboud University Phase 4 2012-04-01 2013-04-26
    NCT01091571 Endotoxemia Drug: Dipyridamole|Drug: Placebo|Other: LPS Radboud University Phase 4 2010-03-01 2010-11-04
    NCT00349973 Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder Drug: Dipyridamole|Other: Olanzapine University of Maryland 2001-05-01 2013-01-11
    NCT00430170 Cardiovascular Disease|Ischemia-Reperfusion Injury Drug: Dipyridamole|Drug: caffeine Radboud University Phase 4 2007-01-01 2008-07-28
    NCT00767663 Coronary Heart Disease|Percutaneous Transluminal Coronary Angioplasty|Atherosclerosis Drug: dipyridamole|Drug: placebo Radboud University Phase 4 2008-10-01 2015-10-29
    NCT01781611 Systemic Lupus Erythematosus Drug: extended release dipyridamole 200mg/aspirin 25mg|Drug: 81mg aspirin Oklahoma Medical Research Foundation 2013-02-01 2016-09-26
    NCT00808314 Coronary Artery Disease Drug: Rest/Dipyridamole Stress Rb-82 Myocardial Perfusion PET/CT|Drug: Rest/Lexiscan(TM) Stress Rb-82 Myocardial Perfusion PET Cardiovascular Imaging Technologies|Astellas Pharma US, Inc. Phase 4 2008-12-01 2012-08-01
    NCT00763009 Coronary Artery Disease Drug: dipyridamole UConn Health|United States Department of Defense Phase 4 2002-09-01 2012-11-08
    NCT02226926 Healthy Drug: Aggrenox|Drug: Persantin Retard|Drug: Acetylsalicylic acid Boehringer Ingelheim Phase 1 2000-07-01 2014-08-26
    NCT00960817 Coronary Angiography Drug: Statin, aspirin|Drug: Dipyridamole Hillel Yaffe Medical Center Early Phase 1 2009-08-17
    NCT00276146 Anemia, Sickle Cell Drug: oral dipyridamole, oral magnesium, or a combination of both Children's Hospital Medical Center, Cincinnati Phase 2 2005-05-01 2013-08-05
    NCT01593644 Ischemic Heart Disease Drug: adenosine + dipyridamole Adenobio N.V Phase 2 2011-06-01 2012-09-06
    NCT00002487 Ovarian Cancer Drug: dipyridamole|Drug: methotrexate Ottawa Regional Cancer Centre|National Cancer Institute (NCI) Phase 2 1991-07-01 2013-09-16
    NCT02268773 Healthy Drug: Asasantin|Drug: Acetylsalicylic acid low dose|Drug: Acetylsalicylic acid high dose Boehringer Ingelheim Phase 1 2000-01-01 2014-10-17
    NCT03084562 Myocardial Perfusion Imaging Other: collect examination time, functional and clinical tolerability Hospices Civils de Lyon 2017-03-01 2017-03-14
    NCT02273557 Healthy Drug: Asasantin ER (new formulation I - low)|Drug: Asasantin ER (new formulation III - medium)|Drug: Asasantin ER (new formulation II - high)|Drug: Asasantin ER (present commercial formulation) Boehringer Ingelheim Phase 1 2003-01-01 2014-10-23
    NCT00129038 Coronary Arteriosclerosis Drug: modified-release dipyridamole/aspirin|Drug: aspirin Boehringer Ingelheim Phase 4 2004-04-01 2013-10-28
    NCT02251184 Healthy Drug: Aggrenox|Drug: Dipyridamole|Drug: Aspirin|Drug: Lansoprazole Boehringer Ingelheim Phase 4 2000-10-01 2014-09-25

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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