Acebutolol HCl

盐酸醋丁洛尔,Sectral

Acebutolol HCl是beta-adrenergic receptors(β-肾上腺素能受体)拮抗剂,用于治疗高血压,心绞痛,和心律失常。

目录号
EY1195
EY1195
纯度
99.31%
99.31%
规格
50 mg
100 mg
原价
480
782
售价
480
782
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    10 mg/kg静脉注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Street JA, et al. Eur J Pharmacol, 1984, 102(2), 315-324.

    分子式
    C18H28N2O4.HCl
    分子量
    372.89
    CAS号
    34381-68-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    200 mM
    Water
    200 mM
    Ethanol
    200 mM

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01514019 Healthy Drug: Acebutolol|Drug: Placebo In-Jin Jang, MD, PhD|Oita University|Seoul National University Hospital|Kyushu University Phase 4 2012-01-01 2012-06-19
    NCT01743885 Hemangioma Drug: Acebutolol|Drug: Propanolol University Hospital, Montpellier Phase 3 2012-11-01 2016-05-31
    NCT02439086 Rectal Neoplasms Device: PET-CT Scan Colchester General Hospital|Anglia Ruskin University 2015-09-01 2015-05-08
    NCT02189759 Hypothermia|Newborn Other: Continuous Kangaroo Mother Care to one hour after birth|Other: Standard Kangaroo Mother Care to one hour after birth|Other: Continuous Kangaroo Mother Care to discharge|Other: Standard Kangaroo Mother Care to discharge University of Alabama at Birmingham 2014-06-01 2016-01-29
    NCT00340470 Behavioral Intervention Behavioral: Driver Education Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) Phase 3 2003-07-24 2017-01-24
    NCT00684489 Hypertension Drug: clinical hypertension specialist-no specific med. Any anti-hypertension meds.|Drug: renin guided therapeutics-no specific med. Any anti-hypertensive med. Medical University of South Carolina|New York Presbyterian Hospital 2003-09-01 2008-05-22
    NCT00911508 Atrial Fibrillation|Arrhythmia Device: Left atrial ablation|Drug: Rate or Rhythm Control Therapy Mayo Clinic|National Heart, Lung, and Blood Institute (NHLBI)|St. Jude Medical|Biosense Webster, Inc. 2009-08-01 2016-04-25
    NCT00000522 Cardiovascular Diseases|Heart Diseases|Hypertension|Vascular Diseases Behavioral: diet, sodium-restricted|Behavioral: diet, reducing|Behavioral: exercise|Behavioral: alcohol restriction|Drug: chlorthalidone|Drug: acebutolol|Drug: doxazosin|Drug: amlodipine|Drug: enalapril University of Minnesota - Clinical and Translational Science Institute|National Heart, Lung, and Blood Institute (NHLBI) Phase 2 1985-08-01 2016-02-24
    NCT00578617 Atrial Fibrillation|Arrhythmia Drug: Rate Control|Device: Ablation Therapy|Drug: Rate Control|Drug: Rate control|Drug: Rate control|Drug: Rate control|Drug: Rate Control|Drug: Rate Control|Drug: Rate Control|Drug: Rhythm Control|Drug: Rhythm control|Drug: Rhythm control|Drug: Rhythm control|Drug: Rhythm control|Drug: Rhythm control Mayo Clinic|Duke Clinical Research Institute|St. Jude Medical 2006-09-01 2012-12-03
    NCT01316952 Hypersensitivity Drug: Carvedilol immediate release only|Drug: Carvedilol extended release only|Drug: Long acting-blockers|Drug: Other 1-adrenergic antagonists|Drug: Short acting Non-selective-blockers and short acting 1-Selective agents|Other: No-blocker GlaxoSmithKline 2010-06-01 2015-04-14

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :