Acebutolol HCl是beta-adrenergic receptors(β-肾上腺素能受体)拮抗剂,用于治疗高血压,心绞痛,和心律失常。
Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
10 mg/kg静脉注射
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Street JA, et al. Eur J Pharmacol, 1984, 102(2), 315-324.
分子式 C18H28N2O4.HCl |
分子量 372.89 |
CAS号 34381-68-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 200 mM |
Water 200 mM |
Ethanol 200 mM |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01514019 | Healthy | Drug: Acebutolol|Drug: Placebo | In-Jin Jang, MD, PhD|Oita University|Seoul National University Hospital|Kyushu University | Phase 4 | 2012-01-01 | 2012-06-19 |
NCT01743885 | Hemangioma | Drug: Acebutolol|Drug: Propanolol | University Hospital, Montpellier | Phase 3 | 2012-11-01 | 2016-05-31 |
NCT02439086 | Rectal Neoplasms | Device: PET-CT Scan | Colchester General Hospital|Anglia Ruskin University | 2015-09-01 | 2015-05-08 | |
NCT02189759 | Hypothermia|Newborn | Other: Continuous Kangaroo Mother Care to one hour after birth|Other: Standard Kangaroo Mother Care to one hour after birth|Other: Continuous Kangaroo Mother Care to discharge|Other: Standard Kangaroo Mother Care to discharge | University of Alabama at Birmingham | 2014-06-01 | 2016-01-29 | |
NCT00340470 | Behavioral Intervention | Behavioral: Driver Education | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) | Phase 3 | 2003-07-24 | 2017-01-24 |
NCT00684489 | Hypertension | Drug: clinical hypertension specialist-no specific med. Any anti-hypertension meds.|Drug: renin guided therapeutics-no specific med. Any anti-hypertensive med. | Medical University of South Carolina|New York Presbyterian Hospital | 2003-09-01 | 2008-05-22 | |
NCT00911508 | Atrial Fibrillation|Arrhythmia | Device: Left atrial ablation|Drug: Rate or Rhythm Control Therapy | Mayo Clinic|National Heart, Lung, and Blood Institute (NHLBI)|St. Jude Medical|Biosense Webster, Inc. | 2009-08-01 | 2016-04-25 | |
NCT00000522 | Cardiovascular Diseases|Heart Diseases|Hypertension|Vascular Diseases | Behavioral: diet, sodium-restricted|Behavioral: diet, reducing|Behavioral: exercise|Behavioral: alcohol restriction|Drug: chlorthalidone|Drug: acebutolol|Drug: doxazosin|Drug: amlodipine|Drug: enalapril | University of Minnesota - Clinical and Translational Science Institute|National Heart, Lung, and Blood Institute (NHLBI) | Phase 2 | 1985-08-01 | 2016-02-24 |
NCT00578617 | Atrial Fibrillation|Arrhythmia | Drug: Rate Control|Device: Ablation Therapy|Drug: Rate Control|Drug: Rate control|Drug: Rate control|Drug: Rate control|Drug: Rate Control|Drug: Rate Control|Drug: Rate Control|Drug: Rhythm Control|Drug: Rhythm control|Drug: Rhythm control|Drug: Rhythm control|Drug: Rhythm control|Drug: Rhythm control | Mayo Clinic|Duke Clinical Research Institute|St. Jude Medical | 2006-09-01 | 2012-12-03 | |
NCT01316952 | Hypersensitivity | Drug: Carvedilol immediate release only|Drug: Carvedilol extended release only|Drug: Long acting-blockers|Drug: Other 1-adrenergic antagonists|Drug: Short acting Non-selective-blockers and short acting 1-Selective agents|Other: No-blocker | GlaxoSmithKline | 2010-06-01 | 2015-04-14 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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