Home > Estrogen/progestogen Receptor & > Megestrol Acetate

Megestrol Acetate

醋酸甲地孕酮,BDH1298,SC10363,Megace,Ovaban,SC 10363,SC-10363,BDH 1298

Megestrol Acetate能抑制HegG2，IC50为260 μM。

目录号
EY1194
EY1194
EY1194
纯度
99.13%
99.13%
99.13%
规格
500 mg
1 g
5 g
原价
380
490
1300
售价
380
490
1300
库存
现货
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Megestrol acetate is a synthetic progestogen, used to treat breast cancer and loss of appetite.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Kelicen Ugur P, et al. Eur J Pharmacol, 2011, 654(3), 217-225.

    分子式
    C24H32O4    		 分子量
    384.51    		 CAS号
    595-33-5    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    33 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    15 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01968317 Endometrial Atypical Hyperplasia|Endometrial Adenocarcinoma Drug: Megestrol acetate and metformin|Drug: Megestrol acetate Xiaojun Chen|Fudan University|Shanghai 6th People's Hospital|Zhejiang Cancer Hospital|Shanghai Changning Maternity & Infant Health Hospital Phase 2 2013-10-01 2016-12-09
    NCT00637572 HIV Infections|Cachexia|Anorexia|AIDS Wasting Syndrome|HIV Wasting Syndrome Drug: Megestrol acetate oral suspension nanocrystal dispersion 115 mg/mL|Drug: Megestrol acetate oral suspension 40 mg/mL Endo Pharmaceuticals|Quintiles, Inc. Phase 2 2004-12-01 2016-09-14
    NCT00483327 Atypical Endometrial Hyperplasia|Endometrial Carcinoma Drug: Megestrol Acetate New York University School of Medicine Phase 2 2007-06-01 2016-12-08
    NCT00638079 Pharmacokinetics|Bioavailability|Absorption Drug: Megestrol acetate oral suspension 625 mg/5 mL|Drug: Megestrol acetate oral suspension 625 mg/5 mL Endo Pharmaceuticals|SFBC Anapharm Phase 1 2006-06-01 2016-04-18
    NCT00637806 Anorexia|Cachexia|Weight Loss Drug: Megestrol acetate concentrated suspension 110 mg/mL|Drug: Megestrol acetate concentrated suspension 60 mg/mL|Drug: Placebo Par Pharmaceutical, Inc.|PRA Health Sciences Phase 3 2006-06-01 2016-03-31
    NCT00637728 Anorexia|Cachexia|Weight Loss Drug: Megestrol acetate concentrated suspension 110 mg/mL|Drug: Placebo Par Pharmaceutical, Inc.|PRA Health Sciences Phase 3 2006-06-01 2016-05-18
    NCT00005975 Breast Cancer|Hot Flashes Drug: Megestrol Acetate 20mg/day|Drug: Megestrol Acetate 40 mg/day|Drug: Megestrol Acetate Placebo 20 mg/day|Drug: Megestrol Acetate Placebo 40 mg/day Southwest Oncology Group|National Cancer Institute (NCI) Phase 3 1998-04-01 2015-11-17
    NCT00503516 Dementia Drug: Megestrol acetate|Drug: Placebo Rottapharm Spain Phase 2|Phase 3 2007-06-01 2011-06-07
    NCT00507949 Chronic Obstructive Pulmonary Disease Drug: Megestrol acetate|Drug: placebo Rottapharm Spain Phase 2 2006-10-01 2011-06-07
    NCT00066248 Brain Tumor|Central Nervous System Tumors|Cachexia|Leukemia|Lymphoma|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases|Unspecified Childhood Solid Tumor, Protocol Specific Drug: cyproheptadine hydrochloride|Drug: megestrol acetate University of South Florida|National Cancer Institute (NCI) Phase 2 2003-06-01 2014-01-31
    NCT01501396 Anorexia Drug: Megestrol Acetate|Drug: Mirtazapine Washington University School of Medicine Phase 2 2013-09-01 2014-01-31
    NCT00575029 Adrenal Insufficiency Drug: megestrol acetate University of Arkansas 2004-04-01 2011-07-27
    NCT01237327 Metastatic Breast Cancer Drug: Megestrol acetate|Drug: exemestane (Aromasin) Pfizer Phase 3 2001-11-01 2011-05-03
    NCT02644408 Stage III Esophageal Squamous Cell Carcinoma|Stage II Esophageal Squamous Cell Carcinoma Drug: Megestrolining Radiation: radiotherapy|Other: chemotherapy The First Affiliated Hospital of Henan University of Science and Technology Phase 3 2014-10-01 2016-07-02
    NCT00002182 HIV Infections Drug: Megestrol acetate Gamma Project - ACTU|NIH AIDS Clinical Trials Information Service 2005-06-23
    NCT01589562 Healthy Drug: Megace 800mg/20ml|Drug: DW-ES(B) 625mg/5ml Daewon Pharmaceutical Co., Ltd.|Asan Medical Center Phase 1 2012-04-01 2013-01-21
    NCT01200602 Anorexia|Weight Changes Drug: megestrol acetate|Other: clinical observation Mayo Clinic|National Cancer Institute (NCI) Phase 2 2011-03-01 2015-10-29
    NCT02980653 Head and Neck Cancer Drug: Megestrol acetate (MA) 400 mg/day TTY Biopharm|Chang Gung Memorial Hospital Phase 2 2015-05-01 2017-01-16
    NCT00002067 Anorexia|Cachexia|HIV Infections Drug: Megestrol acetate Bristol-Myers Squibb Phase 3 2007-10-01
    NCT00002300 Anorexia|Cachexia|HIV Infections Drug: Megestrol acetate Bristol-Myers Squibb Phase 2 2007-10-01
    NCT00637403 Healthy Drug: Megestrol acetate concentrated suspension 125 mg/mL|Drug: Megestrol acetate concentrated suspension 125 mg/mL|Drug: Megestrol acetate concentrated suspension 125 mg/mL|Drug: Megestrol acetate concentrated suspension 125 mg/mL|Drug: Megestrol acetate concentrated suspension 125 mg/mL Par Pharmaceutical, Inc.|Covance|SFBC Anapharm Phase 1 2006-05-01 2016-10-13
    NCT00070148 Unspecified Adult Solid Tumor, Protocol Specific|Weight Changes Drug: Megestrol Acetate|Drug: Oxandrolone 20 mg Wake Forest University Health Sciences|National Cancer Institute (NCI) Phase 3 2004-03-01 2016-12-20
    NCT00163072 Cachexia Drug: transdermal Megace Milton S. Hershey Medical Center Phase 4 2005-10-01 2013-10-24

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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