Chlorpropamide是一种口服降糖剂, 用于治疗非胰岛素依赖型糖尿病 (NIDDM)。
Chlorpropamide is a sulfonylurea class drug for type 2 diabetes mellitus.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Monge L, et al. Diabetes, 1986, 35(1), 89-96.
分子式 C10H13ClN2O3S |
分子量 276.74 |
CAS号 94-20-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 55 mg/mL |
Water <1 mg/mL |
Ethanol 55 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00004363 | Diabetes Insipidus|Diabetes Insipidus, Neurohypophyseal | Drug: chlorpropamide|Drug: desmopressin | National Center for Research Resources (NCRR)|Northwestern University | 1995-12-01 | 2005-06-23 | |
NCT01068860 | Type 2 Diabetes Mellitus|Impaired Glucose Tolerance | Drug: Canakinumab 150 mg|Drug: Placebo to Canakinumab | Novartis | Phase 2 | 2010-02-01 | 2011-08-03 |
NCT02475499 | Diabetes Mellitus, Type 2 | Drug: DPP-4 inhibitors|Drug: GLP-1 analogs|Drug: Sulfonylureas|Drug: Biguanides|Drug: Thiazolidinediones|Drug: Alpha-glucosidase inhibitors|Drug: Meglitinides | Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) | 2014-03-01 | 2016-03-11 | |
NCT02476760 | Diabetes Mellitus, Type 2 | Drug: DPP-4 inhibitors|Drug: GLP-1 analogs|Drug: Insulins|Drug: Biguanides|Drug: Sulfonylureas|Drug: Thiazolidinediones|Drug: Alpha-glucosidase inhibitors|Drug: Meglitinides | Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) | 2014-03-01 | 2016-11-01 | |
NCT02456428 | Type 2 Diabetes Mellitus | Drug: DPP-4 inhibitors|Drug: GLP-1 analogs|Drug: Insulins|Drug: Biguanides|Drug: Sulfonylureas|Drug: Thiazolidinediones|Drug: Alpha-glucosidase inhibitors|Drug: Meglitinides | Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) | 2014-03-01 | 2016-04-15 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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