Home > DNA/RNA Synthesis & > Fludarabine Phosphate

Fludarabine Phosphate

磷酸氟达拉滨,磷酸氟达拉宾,磷酸氟达那甙,磷酸氟达那苷,F-ara-A,NSC 312887 Phosphate,Fludura

Fludarabine phosphate是胸苷和脱氧腺苷的类似物,能与dATP竞争结合并整合入DNA中,可抑制DNA合成。

目录号
EY1184
EY1184
EY1184
EY1184
EY1184
纯度
99.49%
99.49%
99.49%
99.49%
99.49%
规格
1 mg
5 mg
10 mg
50 mg
100 mg
原价
190
420
682
1800
2400
售价
190
420
682
1800
2400
库存
现货
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    30 μM

  • 动物实验

    234 mg/kg 腹腔注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Huang P, et al, J Biol Chem, 1990, 265(27), 16617-16625.

    分子式
    C10H13FN5O7P
    分子量
    365.21
    CAS号
    75607-67-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    72 mg/mL
    Water
    2 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01472055 Acute Leukemia|Chronic Leukemia|Severe Aplastic Anemia Drug: Fludarabine Seoul National University Hospital|Ministry of Food and Drug Safety, Korea Phase 2 2011-10-01 2014-08-18
    NCT01310179 Head and Neck Cancer Genetic: Ad/PNP and fludarabine monophosphate PNP Therapeutics, Inc. Phase 1 2011-02-01 2015-05-26
    NCT02649764 Leukemia Drug: Fludarabine|Drug: Cytarabine|Drug: LY2606368 M.D. Anderson Cancer Center|Eli Lilly and Company Phase 1 2016-05-01 2017-02-16
    NCT00004246 Head and Neck Cancer Drug: Fludarabine Phosphate|Radiation: Radiation Therapy (RT) M.D. Anderson Cancer Center|National Cancer Institute (NCI) Phase 1 2000-05-01 2012-07-27
    NCT00208975 Lymphoma Drug: Mitoxantrone/Cyclophosphamide, Fludarabine, Rituximab and GM-CSF Emory University|Bayer Phase 2 2002-07-01 2012-05-25
    NCT02718755 Hematologic Malignancy Drug: Fludarabine|Drug: Cytarabine|Drug: Erwinase M.D. Anderson Cancer Center|Jazz Pharmaceuticals Phase 2 2016-12-01 2016-09-19
    NCT00278265 T-Cell Large Granular Lymphocytic Leukemia Drug: MTX followed by fludarabine German CLL Study Group Phase 2 2005-06-01 2016-09-30
    NCT00086580 B-Cell Chronic Lymphocytic Leukemia Biological: FluCAM [Fludara + Campath]|Biological: fludarabine phosphate Genzyme, a Sanofi Company|Sanofi Phase 3 2004-07-01 2014-02-10
    NCT01096992 Leukemia Drug: Bendamustine|Drug: Fludarabine|Drug: Rituximab M.D. Anderson Cancer Center Phase 1|Phase 2 2010-04-01 2016-08-17
    NCT00098670 B-cell Chronic Lymphocytic Leukemia|Stage I Chronic Lymphocytic Leukemia|Stage II Chronic Lymphocytic Leukemia|Stage III Chronic Lymphocytic Leukemia|Stage IV Chronic Lymphocytic Leukemia Biological: alemtuzumab|Biological: rituximab|Drug: fludarabine phosphate National Cancer Institute (NCI) Phase 2 2004-10-01 2014-05-06
    NCT00502905 Leukemia Drug: Busulfan|Drug: Fludarabine M.D. Anderson Cancer Center Phase 2 2003-10-01 2012-05-23
    NCT02926586 Acute Myeloid Leukemia|Core-Binding Factor Drug: Fludarabine|Drug: Cytarabine Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Phase 4 2016-07-01 2016-10-05
    NCT00185445 Non Hodgkin Lymphoma Drug: Fludarabine Phosphate (Fludara) Genzyme, a Sanofi Company|Sanofi Phase 2 2004-06-01 2013-12-02
    NCT00625430 Prostate Cancer Biological: Gene Directed Enzyme Prodrug Therapy, FP253/Fludarabine Biotech Equity Partners Pty Ltd Phase 1 2008-03-01 2011-07-08
    NCT00506857 Hematologic Malignancies Drug: Busulfan|Drug: Fludarabine M.D. Anderson Cancer Center Phase 1|Phase 2 2003-11-01 2012-01-24
    NCT00688883 Lymphoma Drug: Fludarabine Phosphate (Fludara) Genzyme, a Sanofi Company|Sanofi Phase 2 2003-02-01 2013-12-02
    NCT01019317 Leukemia|AML|MDS|CML Drug: Cytarabine|Drug: Fludarabine M.D. Anderson Cancer Center Phase 2 2009-11-01 2016-02-17
    NCT00006251 Acute Undifferentiated Leukemia|Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Childhood Burkitt Lymphoma|Childhood Diffuse Large Cell Lymphoma|Childhood Grade III Lymphomatoid Granulomatosis|Childhood Immunoblastic Large Cell Lymphoma|Childhood Myelodysplastic Syndromes|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Chronic Myelomonocytic Leukemia|Cutaneous B-cell Non-Hodgkin Lymphoma|de Novo Myelodysplastic Syndromes|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Juvenile Myelomonocytic Leukemia|Mast Cell Leukemia|Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable|Myeloid/NK-cell Acute Leukemia|Nodal Marginal Zone B-cell Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Previously Treated Myelodysplastic Syndromes|Primary Systemic Amyloidosis|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Renal Cell Cancer|Recurrent Small Lymphocytic Lymphoma|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Refractory Multiple Myeloma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage II Multiple Myeloma|Stage III Multiple Myeloma|T-cell Large Granular Lymphocyte Leukemia|Testicular Lymphoma|Waldenstrm Macroglobulinemia Radiation: total-body irradiation|Drug: fludarabine phosphate|Drug: cyclosporine|Drug: mycophenolate mofetil|Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation|Biological: donor lymphocytes|Procedure: peripheral blood stem cell transplantation|Other: laboratory biomarker analysis Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Phase 1|Phase 2 2000-05-01 2016-08-01
    NCT00815568 AML|MDS|ALL|CML|Lymphoma Drug: fludarabine phosphate, busulfan Samsung Medical Center Phase 2 2008-08-01 2008-12-29
    NCT00058227 B-cell Chronic Lymphocytic Leukemia|Contiguous Stage II Grade 1 Follicular Lymphoma|Contiguous Stage II Grade 2 Follicular Lymphoma|Contiguous Stage II Mantle Cell Lymphoma|Contiguous Stage II Marginal Zone Lymphoma|Contiguous Stage II Small Lymphocytic Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Noncontiguous Stage II Grade 1 Follicular Lymphoma|Noncontiguous Stage II Grade 2 Follicular Lymphoma|Noncontiguous Stage II Mantle Cell Lymphoma|Noncontiguous Stage II Marginal Zone Lymphoma|Noncontiguous Stage II Small Lymphocytic Lymphoma|Progressive Hairy Cell Leukemia, Initial Treatment|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Splenic Marginal Zone Lymphoma|Stage I Chronic Lymphocytic Leukemia|Stage I Grade 1 Follicular Lymphoma|Stage I Grade 2 Follicular Lymphoma|Stage I Mantle Cell Lymphoma|Stage I Marginal Zone Lymphoma|Stage I Small Lymphocytic Lymphoma|Stage II Chronic Lymphocytic Leukemia|Stage III Chronic Lymphocytic Leukemia|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage III Marginal Zone Lymphoma|Stage III Small Lymphocytic Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Small Lymphocytic Lymphoma|Untreated Hairy Cell Leukemia|Waldenstr枚m Macroglobulinemia Drug: alvocidib|Drug: fludarabine phosphate|Biological: rituximab|Other: pharmacological study National Cancer Institute (NCI) Phase 1 2003-04-01 2013-06-03
    NCT00882323 Aplastic Anemia Drug: Cyclophosphamide, Fludarabine, Thymoglobulin The Korean Society of Pediatric Hematology Oncology Phase 2 2008-11-01 2012-03-23

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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