Home > DNA/RNA Synthesis & > Daptomycin

Daptomycin

达托霉素,达妥霉素,达帕托霉素,Dapcin,LY 146032,LY146032,LY-146032,

Daptomycin是脂肽抗菌剂，对革兰氏阳性菌尤其是多药抗性株有效。

目录号
EY1180
EY1180
EY1180
EY1180
纯度
99.51%
99.51%
99.51%
99.51%
规格
5 mg
10 mg
50 mg
100 mg
原价
180
320
998
1800
售价
180
320
998
1800
库存
现货
现货
现货
现货
订购
订购
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  • 生物活性

    Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Silverman JA, et al. Antimicrob Agents Chemother, 2003, 47(8), 2538-2544.

    分子式
    C72H101N17O26    		 分子量
    1620.67    		 CAS号
    103060-53-3    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    <1 mg/mL    		 Water
    100 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01012089 Chronic Kidney Disease|Bacterial Infection Drug: Daptomycin University of Oklahoma|Cubist Pharmaceuticals LLC 2009-11-01 2014-12-02
    NCT01196169 Staphylococcal Infections|Methicillin-resistant Staphylococcus Aureus Drug: Daptomycin|Drug: Vancomycin Mountain Home Research & Education Corporation|East Tennessee State University|Cubist Pharmaceuticals LLC Phase 4 2010-10-01 2014-01-31
    NCT01144000 Staphylococcal Infections Drug: Daptomycin Andrej Trampuz|University of Lausanne Hospitals|Kantonsspital Liestal|Schulthess Klinik|Centre Hospitalier Universitaire Vaudois Phase 2 2012-06-01 2012-06-24
    NCT00335478 Fever|Sweating|Hot Flashes|Infection|Neutropenia|Unspecified Adult Solid Tumor, Protocol Specific Drug: Daptomycin OHSU Knight Cancer Institute Phase 2 2006-12-01 2015-10-20
    NCT00942149 Sepsis Drug: Daptomycin Duke University Phase 1 2010-01-01 2013-07-01
    NCT00701636 Late Effects of Surgery|Staphylococcus Aureus|Surgical Site Infection Drug: daptomycin Los Angeles Biomedical Research Institute|Cubist Pharmaceuticals LLC|Hartford Hospital|Western University of Health Sciences Phase 3 2008-07-01 2016-07-19
    NCT00679835 Gram Positive Infection|Concurrent Antibiotic Treatment Drug: daptomycin Cubist Pharmaceuticals LLC Phase 1 2008-05-01 2015-07-27
    NCT01522105 Meningitis Drug: Daptomycin University Hospital Inselspital, Berne Phase 1 2012-04-01 2015-12-10
    NCT01025271 Meningitis Drug: Daptomycin University of Pittsburgh|Cubist Pharmaceuticals LLC 2010-05-01 2013-08-08
    NCT00663403 Critically Ill|Hemodialysis Drug: Daptomycin University of Michigan|Cubist Pharmaceuticals LLC Phase 4 2007-02-01 2015-12-01
    NCT02508350 Septic Shock Drug: Daptomycin|Other: determination of plasma concentration Zhongda Hospital 2015-01-01 2015-07-22
    NCT02241941 Burn Injury Drug: Daptomycin University of Zurich Phase 4 2014-09-01 2016-10-27
    NCT02972983 Methicillin Susceptible Staphylococcus Aureus Septicemia|Bacteremia Drug: Daptomycin|Other: Placebo McGill University Health Center Phase 4 2016-11-01 2016-11-23
    NCT02097953 Drug Interactions|Pharmacokinetics Drug: Daptomycin|Drug: Rifampin University of Utah|Cubist Pharmaceuticals LLC Early Phase 1 2014-05-01 2016-12-09
    NCT00463801 Staphylococcal Skin Infections Drug: Daptomycin Novartis Phase 4 2007-01-01 2011-03-22
    NCT00507247 Staphylococcus Aureus Drug: Daptomycin M.D. Anderson Cancer Center|Cubist Pharmaceuticals LLC Phase 2 2006-05-01 2016-07-18
    NCT00638157 Infective Endocarditis Drug: daptomycin|Drug: daptomycin and gentamicin Cubist Pharmaceuticals LLC Phase 4 2008-03-01 2016-01-05
    NCT00467272 Bloodstream Infection Drug: Daptomycin M.D. Anderson Cancer Center|Cubist Pharmaceuticals LLC Phase 2 2007-03-01 2012-09-18
    NCT01019395 Gram Positive Bacterial Infection Drug: Daptomycin Cubist Pharmaceuticals LLC Phase 1 2009-11-01 2012-05-22
    NCT01199783 Diabetic Foot Drug: Daptomycin|Drug: Vancomycin Ruhr University of Bochum Phase 3 2011-07-01 2015-05-04
    NCT00711802 Skin Diseases, Infectious Drug: Daptomycin|Drug: Standard of Care (SOC) Cubist Pharmaceuticals LLC Phase 4 2008-07-01 2017-02-22
    NCT00695903 Endocarditis, Bacterial|Infective Endocarditis Drug: daptomycin|Drug: vancomycin Cubist Pharmaceuticals LLC Phase 2 2008-09-01 2017-02-22
    NCT01975662 Bacteremia Due to Staphylococcus Aureus Drug: Daptomycin|Drug: Vancomycin Singapore General Hospital|Singapore Clinical Research Institute Phase 2 2014-01-01 2016-04-12
    NCT01080963 Wound Infection Drug: Daptomycin|Drug: Cefuroxime Hannover Medical School|Novartis Phase 4 2008-11-01 2012-04-16
    NCT01419184 Staphylococcal Skin Infections Drug: Daptomycin|Drug: Vancomycin Cubist Pharmaceuticals LLC Phase 4 2011-08-01 2016-01-05

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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