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Atazanavir Sulfate

硫酸阿扎那韦,BMS-232632

Atazanavir sulfate (硫酸阿扎那韦) 是HIV-1蛋白酶高活性抑制剂。

目录号
EY1168
EY1168
EY1168
纯度
99.47%
99.47%
99.47%
规格
5 mg
10 mg
50 mg
原价
320
530
1550
售价
320
530
1550
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Atazanavir Sulfate is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    15 nM

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Robinson BS, et al. Antimicrob Agents Chemother, 2000, 44(8), 2093-2099.

    分子式
    C38H54N6O11S
    分子量
    802.93
    CAS号
    229975-97-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    103 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01837719 Human Immunodeficiency Virus Type 1 (HIV-1) Drug: Atazanavir|Drug: Cobicistat|Drug: Atazanavir/Cobicistat FDC Bristol-Myers Squibb Phase 1 2013-04-01 2014-08-19
    NCT00916448 Endotoxemia|Inflammation|Multi Organ Dysfunction Syndrome|Sepsis Drug: Atazanavir|Drug: E. coli endotoxin Radboud University 2009-05-01 2015-08-13
    NCT00940771 Pediatric HIV|HIV Infections Drug: Boosted Atazanavir Phoenix Children's Hospital|Bristol-Myers Squibb Phase 4 2009-04-01 2015-10-21
    NCT01404572 HIV Drug: Atazanavir (current formulation)|Drug: Atazanavir, powder for oral use 1 (POU1)|Drug: Atazanavir (POU2) Bristol-Myers Squibb Phase 1 2011-08-01 2013-05-03
    NCT03019783 HIV Drug: Atazanavir|Other: Placebo Brigham and Women's Hospital Phase 2|Phase 3 2011-12-01 2017-01-11
    NCT01599364 Human Immunodeficiency Virus Drug: Atazanavir, ritonavir, lamivudine Catholic University of the Sacred Heart Phase 4 2014-04-01 2016-08-14
    NCT00357721 HIV Infections|Protease Inhibitor Drug: Atazanavir Sulphate|Drug: Atazanavir Sulphate|Drug: Atazanavir Sulphate Bristol-Myers Squibb Phase 1 2006-06-01 2011-04-05
    NCT02034838 HIV Infection Drug: atazanavir 300mg boosted with ritonavir 50 mg Ottawa Hospital Research Institute|Bristol-Myers Squibb Phase 1 2014-01-01 2015-09-21
    NCT00874523 HIV Infection Drug: atazanavir plus raltegravir|Drug: atazanavir plus raltegravir Kirby Institute Phase 3 2009-07-01 2012-04-10
    NCT00225017 HIV Infection|Hyperlipidemia Drug: Atazanavir|Drug: current antiretroviral regimen Northwestern University|Bristol-Myers Squibb Phase 3 2005-06-01 2012-06-29
    NCT01335698 HIV Drug: Atazanavir Sulphate|Drug: Ritonavir Bristol-Myers Squibb Phase 3 2011-05-01 2017-02-02
    NCT00357188 HIV Infections|Protease Inhibitor Drug: Atazanavir Sulphate + Ritonavir|Drug: Atazanavir Sulphate + Ritonavir + Efavirenz Bristol-Myers Squibb Phase 1 2006-07-01 2011-04-07
    NCT01759875 Healthy Drug: Ritonavir-boosted Atazanavir|Drug: Ritonavir-boosted Atazanavir plus Rabeprazole|Drug: Ritonavir-boosted Atazanavir plus Rabeprazole AND Betaine Hydrochloride University of California, San Francisco Phase 1 2013-01-01 2015-04-24
    NCT00833482 Human Immunodeficiency Virus Type 1 (HIV-1)|HIV Infections Drug: Voriconazole|Drug: Atazanavir|Drug: Ritonavir Bristol-Myers Squibb Phase 1 2009-09-01 2012-09-24
    NCT01928407 HIV-1 Infection|Immunosuppression-related Infectious Disease Drug: DARUNAVIR|Drug: ATAZANAVIR Institut de Mdecine et d'Epidmiologie Applique - Fondation Internationale Lon M'Ba Phase 4 2011-03-01 2013-08-20
    NCT01691794 HIV, Pediatric Drug: Atazanavir|Drug: Ritonavir Bristol-Myers Squibb Phase 4 2012-11-01 2016-02-08
    NCT01099579 HIV Infections Drug: Atazanavir powder|Drug: Ritonavir oral solution|Drug: Atazanavir capsules|Drug: Ritonavir capsules Bristol-Myers Squibb Phase 3 2011-11-01 2017-02-02
    NCT00357604 HIV Infections Drug: Ortho Tri-Cyclen (ethinyl estradiol + norgestimate)|Drug: Ortho Tri-Cyclen LO (ethinyl estradiol + norgestimate) + Atazanavir/Ritonavir for 14 days then Ortho Tri-Cyclen for 7 days Bristol-Myers Squibb Phase 1 2006-07-01 2011-04-07
    NCT02102048 HIV Drug: Atazanavir University of Roma La Sapienza 2009-01-01 2014-03-28
    NCT00413153 HIV Infections Drug: atazanavir/ritonavir|Drug: lopinavir/ritonavir Massachusetts General Hospital|Bristol-Myers Squibb 2006-05-01 2010-03-05
    NCT01232127 HIV Drug: Atazanavir|Drug: Atazanavir|Drug: Ritonavir|Drug: Ritonavir|Drug: Tenofovir (TDF)|Drug: Tenofovir (TDF)|Drug: Nucleoside Reverse Transcriptase Inhibitor (NRTI)|Drug: Nucleoside Reverse Transcriptase Inhibitor (NRTI)|Drug: Famotidine (FAM)|Drug: Famotidine (FAM) Bristol-Myers Squibb Phase 4 2011-02-01 2012-08-27
    NCT00224445 HIV Infections Drug: Truvada|Drug: Atazanavir|Drug: Ritonavir Gilead Sciences Phase 4 2005-09-01 2013-01-08

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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