Atazanavir sulfate (硫酸阿扎那韦) 是HIV-1蛋白酶高活性抑制剂。
Atazanavir Sulfate is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.
15 nM
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Robinson BS, et al. Antimicrob Agents Chemother, 2000, 44(8), 2093-2099.
分子式 C38H54N6O11S |
分子量 802.93 |
CAS号 229975-97-7 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 103 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01837719 | Human Immunodeficiency Virus Type 1 (HIV-1) | Drug: Atazanavir|Drug: Cobicistat|Drug: Atazanavir/Cobicistat FDC | Bristol-Myers Squibb | Phase 1 | 2013-04-01 | 2014-08-19 |
NCT00916448 | Endotoxemia|Inflammation|Multi Organ Dysfunction Syndrome|Sepsis | Drug: Atazanavir|Drug: E. coli endotoxin | Radboud University | 2009-05-01 | 2015-08-13 | |
NCT00940771 | Pediatric HIV|HIV Infections | Drug: Boosted Atazanavir | Phoenix Children's Hospital|Bristol-Myers Squibb | Phase 4 | 2009-04-01 | 2015-10-21 |
NCT01404572 | HIV | Drug: Atazanavir (current formulation)|Drug: Atazanavir, powder for oral use 1 (POU1)|Drug: Atazanavir (POU2) | Bristol-Myers Squibb | Phase 1 | 2011-08-01 | 2013-05-03 |
NCT03019783 | HIV | Drug: Atazanavir|Other: Placebo | Brigham and Women's Hospital | Phase 2|Phase 3 | 2011-12-01 | 2017-01-11 |
NCT01599364 | Human Immunodeficiency Virus | Drug: Atazanavir, ritonavir, lamivudine | Catholic University of the Sacred Heart | Phase 4 | 2014-04-01 | 2016-08-14 |
NCT00357721 | HIV Infections|Protease Inhibitor | Drug: Atazanavir Sulphate|Drug: Atazanavir Sulphate|Drug: Atazanavir Sulphate | Bristol-Myers Squibb | Phase 1 | 2006-06-01 | 2011-04-05 |
NCT02034838 | HIV Infection | Drug: atazanavir 300mg boosted with ritonavir 50 mg | Ottawa Hospital Research Institute|Bristol-Myers Squibb | Phase 1 | 2014-01-01 | 2015-09-21 |
NCT00874523 | HIV Infection | Drug: atazanavir plus raltegravir|Drug: atazanavir plus raltegravir | Kirby Institute | Phase 3 | 2009-07-01 | 2012-04-10 |
NCT00225017 | HIV Infection|Hyperlipidemia | Drug: Atazanavir|Drug: current antiretroviral regimen | Northwestern University|Bristol-Myers Squibb | Phase 3 | 2005-06-01 | 2012-06-29 |
NCT01335698 | HIV | Drug: Atazanavir Sulphate|Drug: Ritonavir | Bristol-Myers Squibb | Phase 3 | 2011-05-01 | 2017-02-02 |
NCT00357188 | HIV Infections|Protease Inhibitor | Drug: Atazanavir Sulphate + Ritonavir|Drug: Atazanavir Sulphate + Ritonavir + Efavirenz | Bristol-Myers Squibb | Phase 1 | 2006-07-01 | 2011-04-07 |
NCT01759875 | Healthy | Drug: Ritonavir-boosted Atazanavir|Drug: Ritonavir-boosted Atazanavir plus Rabeprazole|Drug: Ritonavir-boosted Atazanavir plus Rabeprazole AND Betaine Hydrochloride | University of California, San Francisco | Phase 1 | 2013-01-01 | 2015-04-24 |
NCT00833482 | Human Immunodeficiency Virus Type 1 (HIV-1)|HIV Infections | Drug: Voriconazole|Drug: Atazanavir|Drug: Ritonavir | Bristol-Myers Squibb | Phase 1 | 2009-09-01 | 2012-09-24 |
NCT01928407 | HIV-1 Infection|Immunosuppression-related Infectious Disease | Drug: DARUNAVIR|Drug: ATAZANAVIR | Institut de Mdecine et d'Epidmiologie Applique - Fondation Internationale Lon M'Ba | Phase 4 | 2011-03-01 | 2013-08-20 |
NCT01691794 | HIV, Pediatric | Drug: Atazanavir|Drug: Ritonavir | Bristol-Myers Squibb | Phase 4 | 2012-11-01 | 2016-02-08 |
NCT01099579 | HIV Infections | Drug: Atazanavir powder|Drug: Ritonavir oral solution|Drug: Atazanavir capsules|Drug: Ritonavir capsules | Bristol-Myers Squibb | Phase 3 | 2011-11-01 | 2017-02-02 |
NCT00357604 | HIV Infections | Drug: Ortho Tri-Cyclen (ethinyl estradiol + norgestimate)|Drug: Ortho Tri-Cyclen LO (ethinyl estradiol + norgestimate) + Atazanavir/Ritonavir for 14 days then Ortho Tri-Cyclen for 7 days | Bristol-Myers Squibb | Phase 1 | 2006-07-01 | 2011-04-07 |
NCT02102048 | HIV | Drug: Atazanavir | University of Roma La Sapienza | 2009-01-01 | 2014-03-28 | |
NCT00413153 | HIV Infections | Drug: atazanavir/ritonavir|Drug: lopinavir/ritonavir | Massachusetts General Hospital|Bristol-Myers Squibb | 2006-05-01 | 2010-03-05 | |
NCT01232127 | HIV | Drug: Atazanavir|Drug: Atazanavir|Drug: Ritonavir|Drug: Ritonavir|Drug: Tenofovir (TDF)|Drug: Tenofovir (TDF)|Drug: Nucleoside Reverse Transcriptase Inhibitor (NRTI)|Drug: Nucleoside Reverse Transcriptase Inhibitor (NRTI)|Drug: Famotidine (FAM)|Drug: Famotidine (FAM) | Bristol-Myers Squibb | Phase 4 | 2011-02-01 | 2012-08-27 |
NCT00224445 | HIV Infections | Drug: Truvada|Drug: Atazanavir|Drug: Ritonavir | Gilead Sciences | Phase 4 | 2005-09-01 | 2013-01-08 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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