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Lamotrigine

拉莫三嗪,那蒙特金,BW-430C,BW 430C,BW430C

Lamotrigine是一种新型抗惊厥药剂,作用于人类血小板和大鼠脑突触体,抑制5-羟色胺(5-HT)吸收,IC50分别为240 μM和474 μM。

目录号
EY1165
EY1165
EY1165
纯度
99.37%
99.37%
99.37%
规格
500 mg
1 g
5 g
原价
470
620
2100
售价
470
620
2100
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    狗和大鼠体内分别为4.5和11.7mg/kg静脉注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Goa KL, et al. Drugs, 1993, 46(1), 152-176.

    分子式
    C9H7Cl2N5
    分子量
    256.09
    CAS号
    84057-84-1
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    10 mg/mL
    Water
    <1 mg/mL
    Ethanol
    3 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00475137 Bipolar II Disorder, Most Recent Episode Major Depressive Drug: Lamotrigine|Drug: Lamotrigine University of British Columbia Phase 2 2007-12-01 2015-06-02
    NCT02513654 Bipolar Disorder Drug: Lamotrigine GlaxoSmithKline Phase 1 2015-09-01 2016-01-14
    NCT02303106 Healthy Drug: Lamotrigine Per Damkier|Odense University Hospital Phase 4 2014-11-01 2015-04-21
    NCT01131975 Healthy Drug: Lamotrigine Dr. Reddy's Laboratories Limited Phase 1 2003-01-01 2010-06-11
    NCT01131949 Healthy Drug: Lamotrigine Dr. Reddy's Laboratories Limited Phase 1 2003-01-01 2010-06-11
    NCT02064465 Epilepsy Drug: Lamotrigine Dispersible/Chewable tablet|Drug: Lamotrigine Compressed tablet GlaxoSmithKline Phase 1 2014-03-01 2017-01-25
    NCT01996293 Bipolar Disorder Drug: lamotrigine Northwestern University 2013-09-01 2016-09-21
    NCT00176228 Bipolar Disorder Drug: Lamotrigine University of Illinois at Chicago|GlaxoSmithKline Phase 2 2004-02-01 2015-07-28
    NCT00621842 Bipolar Disorder|Depression, Bipolar Drug: Lamotrigine regular tablet formulation|Drug: Lamotrigine novel formulation University Hospitals Cleveland Medical Center|GlaxoSmithKline Phase 3 2008-01-01 2014-12-08
    NCT01995825 Epilepsy Drug: lamotrigine University of Maryland|Food and Drug Administration (FDA) Phase 4 2012-05-01 2015-03-12
    NCT00243152 Facial Neuropathy Drug: Lamotrigine Pain and Analgesia Imaging and Neuroscience Group|GlaxoSmithKline 2005-10-01 2012-11-29
    NCT00181844 Bipolar Disorder|Mania Drug: lamotrigine Massachusetts General Hospital Phase 4 2005-01-01 2012-03-09
    NCT02821338 Healthy Drug: Lamotrigine Extended Release Food and Drug Administration (FDA)|Vince & Associates Clinical Research, Inc.|Algorithme Pharma Inc Phase 4 2016-06-01 2017-02-27
    NCT01879423 Epilepsy Drug: Lamotrigine Dispersible/Chewable tablets 5mg*5|Drug: Lamotrigine Compressed tablet 25mg GlaxoSmithKline Phase 1 2013-04-01 2017-01-25
    NCT00789113 Epilepsy|Seizures|Bipolar Disorder|Bipolar Depression Drug: Extended Release Lamotrigine University of Minnesota - Clinical and Translational Science Institute|GlaxoSmithKline Phase 1|Phase 2 2008-11-01 2015-12-14
    NCT01513681 Healthy Drug: Lamotrigine|Drug: Lamictal Dr. Reddy's Laboratories Limited Phase 1 2002-11-01 2012-01-17
    NCT01513720 Healthy Drug: Lamotrigine|Drug: Lamictal Dr. Reddy's Laboratories Limited Phase 1 2002-12-01 2012-01-17
    NCT01042496 Bipolar Depression Drug: Lamotrigine|Procedure: 1H-MR Mayo Clinic|National Institute of Mental Health (NIMH) Phase 3 2009-12-01 2016-01-12
    NCT00896987 Epilepsy Drug: lamotrigine (Lamictal)|Drug: Carbamazepine (Tegretol) Korean Epilepsy Society|GlaxoSmithKline Phase 4 2006-05-01 2009-05-11

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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