Lamotrigine是一种新型抗惊厥药剂,作用于人类血小板和大鼠脑突触体,抑制5-羟色胺(5-HT)吸收,IC50分别为240 μM和474 μM。
Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
狗和大鼠体内分别为4.5和11.7mg/kg静脉注射
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Goa KL, et al. Drugs, 1993, 46(1), 152-176.
分子式 C9H7Cl2N5 |
分子量 256.09 |
CAS号 84057-84-1 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 10 mg/mL |
Water <1 mg/mL |
Ethanol 3 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00475137 | Bipolar II Disorder, Most Recent Episode Major Depressive | Drug: Lamotrigine|Drug: Lamotrigine | University of British Columbia | Phase 2 | 2007-12-01 | 2015-06-02 |
NCT02513654 | Bipolar Disorder | Drug: Lamotrigine | GlaxoSmithKline | Phase 1 | 2015-09-01 | 2016-01-14 |
NCT02303106 | Healthy | Drug: Lamotrigine | Per Damkier|Odense University Hospital | Phase 4 | 2014-11-01 | 2015-04-21 |
NCT01131975 | Healthy | Drug: Lamotrigine | Dr. Reddy's Laboratories Limited | Phase 1 | 2003-01-01 | 2010-06-11 |
NCT01131949 | Healthy | Drug: Lamotrigine | Dr. Reddy's Laboratories Limited | Phase 1 | 2003-01-01 | 2010-06-11 |
NCT02064465 | Epilepsy | Drug: Lamotrigine Dispersible/Chewable tablet|Drug: Lamotrigine Compressed tablet | GlaxoSmithKline | Phase 1 | 2014-03-01 | 2017-01-25 |
NCT01996293 | Bipolar Disorder | Drug: lamotrigine | Northwestern University | 2013-09-01 | 2016-09-21 | |
NCT00176228 | Bipolar Disorder | Drug: Lamotrigine | University of Illinois at Chicago|GlaxoSmithKline | Phase 2 | 2004-02-01 | 2015-07-28 |
NCT00621842 | Bipolar Disorder|Depression, Bipolar | Drug: Lamotrigine regular tablet formulation|Drug: Lamotrigine novel formulation | University Hospitals Cleveland Medical Center|GlaxoSmithKline | Phase 3 | 2008-01-01 | 2014-12-08 |
NCT01995825 | Epilepsy | Drug: lamotrigine | University of Maryland|Food and Drug Administration (FDA) | Phase 4 | 2012-05-01 | 2015-03-12 |
NCT00243152 | Facial Neuropathy | Drug: Lamotrigine | Pain and Analgesia Imaging and Neuroscience Group|GlaxoSmithKline | 2005-10-01 | 2012-11-29 | |
NCT00181844 | Bipolar Disorder|Mania | Drug: lamotrigine | Massachusetts General Hospital | Phase 4 | 2005-01-01 | 2012-03-09 |
NCT02821338 | Healthy | Drug: Lamotrigine Extended Release | Food and Drug Administration (FDA)|Vince & Associates Clinical Research, Inc.|Algorithme Pharma Inc | Phase 4 | 2016-06-01 | 2017-02-27 |
NCT01879423 | Epilepsy | Drug: Lamotrigine Dispersible/Chewable tablets 5mg*5|Drug: Lamotrigine Compressed tablet 25mg | GlaxoSmithKline | Phase 1 | 2013-04-01 | 2017-01-25 |
NCT00789113 | Epilepsy|Seizures|Bipolar Disorder|Bipolar Depression | Drug: Extended Release Lamotrigine | University of Minnesota - Clinical and Translational Science Institute|GlaxoSmithKline | Phase 1|Phase 2 | 2008-11-01 | 2015-12-14 |
NCT01513681 | Healthy | Drug: Lamotrigine|Drug: Lamictal | Dr. Reddy's Laboratories Limited | Phase 1 | 2002-11-01 | 2012-01-17 |
NCT01513720 | Healthy | Drug: Lamotrigine|Drug: Lamictal | Dr. Reddy's Laboratories Limited | Phase 1 | 2002-12-01 | 2012-01-17 |
NCT01042496 | Bipolar Depression | Drug: Lamotrigine|Procedure: 1H-MR | Mayo Clinic|National Institute of Mental Health (NIMH) | Phase 3 | 2009-12-01 | 2016-01-12 |
NCT00896987 | Epilepsy | Drug: lamotrigine (Lamictal)|Drug: Carbamazepine (Tegretol) | Korean Epilepsy Society|GlaxoSmithKline | Phase 4 | 2006-05-01 | 2009-05-11 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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