| NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
| NCT01102686 | Gangliosidoses, GM2|Sandhoff Disease|Tay-Sachs Disease | Drug: Pyrimethamine|Drug: Leucovorin | The Hospital for Sick Children | Phase 1|Phase 2 | 2009-08-01 | 2012-02-22 |
| NCT01066663 | Chronic Lymphocytic Leukemia|Small Lymphocytic Leukemia | Drug: pyrimethamine | Dana-Farber Cancer Institute|Brigham and Women's Hospital|Beth Israel Deaconess Medical Center|Lymphoma Research Foundation | Phase 1|Phase 2 | 2010-03-01 | 2016-10-25 |
| NCT03057990 | Myelodysplastic Syndromes | Drug: Pyrimethamine | University of Kansas Medical Center|Montefiore Medical Center|Albert Einstein College of Medicine, Inc. | Phase 1 | 2017-03-01 | 2017-02-15 |
| NCT01973933 | Healthy | Drug: Metformin and Pyrimethamine | Seoul National University Hospital | Phase 1 | 2013-06-01 | 2013-10-27 |
| NCT00951106 | Malaria, Vivax|Malaria, Falciparum | Drug: Pyrimethamine/sulfdoxine (Fansidar) | Walter Reed Army Institute of Research (WRAIR) | 1998-01-01 | 2010-07-26 |
| NCT01083667 | Familial Amyotrophic Lateral Sclerosis | Drug: Pyrimethamine | Weill Medical College of Cornell University|Muscular Dystrophy Association | Phase 1|Phase 2 | 2009-11-01 | 2016-08-14 |
| NCT01189448 | Congenital Toxoplasmosis | Drug: Pyrimethamine/Sulfadiazine|Drug: Spiramycine | Assistance Publique - Hpitaux de Paris | Phase 3 | 2010-11-01 | 2016-09-28 |
| NCT00679744 | G(M2) Ganglioside|Tay-Sachs Disease Ganglioside|Sandhoff Disease Ganglioside | Drug: Pyrimethamine | Exsar Corporation|University Hospitals Cleveland Medical Center|New York University School of Medicine|The Hospital for Sick Children | Phase 1 | 2008-05-01 | 2013-02-21 |
| NCT01328990 | Malaria | Drug: sulfadoxine-pyrimethamine plus amodiaquine | London School of Hygiene and Tropical Medicine|Cheikh Anta Diop University, Senegal | Phase 1|Phase 2 | 2011-04-01 | 2011-09-16 |
| NCT00380146 | Malaria | Drug: sulfadoxine-pyrimethamine | Professor Karen I Barnes|Global Fund|Medical Research Council, South Africa|University of Cape Town | 2006-09-01 | 2016-10-25 |
| NCT01184911 | Intermittent Preventive Treatment|Placental Malaria | Drug: Sulfadoxine-pyrimethamine | University of California, San Francisco|Centers for Disease Control and Prevention|Uganda Malaria Surveillance Project | Phase 4 | 2010-10-01 | 2015-03-03 |
| NCT00331708 | Malaria | Drug: Artesunate plus sulfadoxine-pyrimethamine | Professor Karen I Barnes|Global Fund|Medical Research Council, South Africa|University of Cape Town | 2006-04-01 | 2016-10-25 |
| NCT00399074 | Sickle Cell Anemia|Malaria | Drug: sulfadoxine pyrimethamine | Makerere University | Phase 3 | 2006-10-01 | 2009-07-01 |
| NCT00065390 | Autoimmune Disease|Lymphatic Disease|Lymphoproliferative Disorder | Drug: Pyrimethamine | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) | Phase 1 | 2003-07-01 | 2008-03-03 |
| NCT00206739 | Malaria|Anemia | Drug: Sulfadoxine (12.5 mg)/Pyrimethamine (250 mg) | Bernhard Nocht Institute for Tropical Medicine|German Federal Ministry of Education and Research|Deutscher Akademischer Austausch Dienst|The Volkswagen Foundation | Phase 4 | 2003-01-01 | 2010-03-29 |
| NCT00000666 | Toxoplasmosis, Cerebral|HIV Infections | Drug: Pyrimethamine | National Institute of Allergy and Infectious Diseases (NIAID) | null | 2012-10-26 |
| NCT01120145 | Malaria in Pregnancy | | Centers for Disease Control and Prevention|University of Malawi College of Medicine | 2010-03-01 | 2013-02-05 |
| NCT00131235 | Malaria|Sexually Transmitted Diseases|Preterm Birth|Pregnancy | Drug: Sulfadoxine-pyrimethamine treatment twice during pregnancy|Drug: Sulfadoxine-pyrimethamine at 4-week intervals|Drug: Sulfadoxine-pyrimethamine every 4 weeks + azithromycin twice | University of Tampere|Academy of Finland|Foundation for Paediatric Research, Finland | Phase 3 | 2003-12-01 | 2014-01-21 |
| NCT01115439 | Falciparum Malaria | Drug: artesunate plus sulfadoxine-pyrimethamine (AS+SP) | University of Oxford|National Malaria and Leishmaniasis Control Program, Afghanistan|World Health Organization | 2010-03-01 | 2012-07-11 |
| NCT00453856 | Malaria | Drug: Sulfadoxine Pyrimethamine | Albert Schweitzer Hospital|Bill and Melinda Gates Foundation | Phase 4 | 2007-03-01 | 2007-08-08 |
| NCT00167739 | Malaria | Drug: Quinine plus sulfadoxine-pyrimethamine | Albert Schweitzer Hospital | Phase 4 | 2003-04-01 | 2005-09-19 |
