CEP-33779是JAK2新型选择性高效抑制剂,IC50值为1.8nM。
CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM, >40- and >800-fold versus JAK1 and TYK2.
55 mg/kg每天两次,口服给药
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Stump KL, et al. Arthritis Res Ther, 2011, 13(2), R68.
分子式 C24H26N6O2S |
分子量 462.57 |
CAS号 1257704-57-6 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 200 mM |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02125500 | Viral Hepatitis C|HIV | Drug: Sofosbuvir/Ledipasvir fixed dose | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) | Phase 2 | 2014-09-01 | 2016-01-04 |
NCT02478229 | Hepatitis C Viral Infection | Drug: Sofosbuvir (SOF) and Ledipasvir (LDV) | University Health Network, Toronto | Phase 3 | 2015-06-01 | 2016-08-04 |
NCT02638233 | Chronic Hepatitis C | Drug: Sofosbuvir 400mg / Ledipasvir 90 mg (FDC) | Wilhelminenspital Vienna|Gilead Sciences | Phase 4 | 2015-09-01 | 2015-12-18 |
NCT02705534 | Hepatitis C|Cirrhosis | Drug: Sofosbuvir|Drug: Ledipasvir|Drug: Ribavirin | Tehran University of Medical Sciences|Bakhtar Bioshimi Co | Phase 3 | 2016-09-01 | 2016-07-03 |
NCT02683005 | Hepatitis C|Pregnancy | Drug: ledipasvir/sofosbuvir | University of Pittsburgh|Gilead Sciences|University of Nebraska | Phase 1 | 2016-09-01 | 2016-11-17 |
NCT02836925 | Indolent B-cell Lymphoma|Hepatitis C | Drug: Sofosbuvir+Ledipasvir|Drug: Sofosbuvir+Ribavirin|Drug: Sofosbuvir+Ledipasvir+Ribavirin | Fondazione Italiana Linfomi ONLUS | Phase 2 | 2016-03-01 | 2016-09-20 |
NCT02421211 | Hepatitis C, Chronic | Drug: Simeprevir (SMV)|Drug: Ledipasvir (LDV)|Drug: Sofosbuvir (SOF) | Janssen Sciences Ireland UC | Phase 2 | 2015-05-01 | 2016-11-07 |
NCT03061032 | Hepatitis C | Drug: Sofosbuvir/Ledipasvir 12W|Drug: Sofosbuvir/Ledipasvir plus Ribavirin 12W|Drug: Sofosbuvir/Ledipasvir 24W|Drug: Sofosbuvir/Ledipasvir plus Ribavirin 24W | Iran Hepatitis Network|Baqiyatallah Research Center for Gastroenterology and Liver Diseases | Phase 3 | 2017-03-01 | 2017-02-17 |
NCT01924949 | Hepatitis C | Drug: LDV/SOF | Gilead Sciences | Phase 2 | 2013-07-01 | 2015-05-13 |
NCT02405013 | Hepatitis C|HIV Infection | Drug: Sofosbuvir|Drug: Ribavirin|Drug: Sofosbuvir|Drug: Ledipasvir | French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) | Phase 2 | 2015-10-01 | 2017-01-11 |
NCT02472886 | Hepatitis C Infection | Drug: LDV/SOF|Drug: RBV | Gilead Sciences | Phase 3 | 2015-06-01 | 2016-07-05 |
NCT02301936 | Hepatitis C Virus Infection | Drug: LDV/SOF | Gilead Sciences | Phase 2 | 2015-03-01 | 2016-04-26 |
NCT02350569 | Hepatitis C Virus Infection | Drug: LDV/SOF | Gilead Sciences | Phase 2 | 2015-05-01 | 2016-04-26 |
NCT02480387 | Treatment of Hepatitis C | Drug: Ledipasvir/Sofosbuvir FDC | Peter J. Ruane, M.D., Inc. | Phase 2 | 2015-05-01 | 2016-07-19 |
NCT02600351 | Hepatitis C Virus Infection | Drug: LDV/SOF|Drug: RBV | Gilead Sciences | Phase 3 | 2015-11-01 | 2016-07-01 |
NCT01984294 | Chronic HCV Infection | Drug: LDV/SOF|Drug: RBV|Drug: GS-9669 | Gilead Sciences | Phase 2 | 2013-10-01 | 2015-04-30 |
NCT02251717 | Hepatitis C Virus Infection | Drug: LDV/SOF | Gilead Sciences | Phase 2 | 2014-10-01 | 2016-07-15 |
NCT03005210 | Healthy | Drug: Magicbuvir Plus|Drug: Harvoni (fist dose)|Drug: Harvoni (second dose) | Genuine Research Center, Egypt|Magic Pharma, Egypt | Phase 1 | 2016-11-01 | 2016-12-28 |
NCT02487030 | Hepatitis C Virus Infection | Drug: LDV/SOF|Drug: RBV | Gilead Sciences | Phase 3 | 2015-09-07 | 2017-02-21 |
NCT02413593 | Hepatitis C Virus Infection | Drug: LDV/SOF|Drug: RBV | Gilead Sciences | Phase 2 | 2015-04-01 | 2016-12-22 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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