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CEP-33779

CEP33779,CEP 33779

CEP-33779是JAK2新型选择性高效抑制剂,IC50值为1.8nM。

目录号
EY1150
EY1150
EY1150
EY1150
纯度
99.45%
99.45%
99.45%
99.45%
规格
1 mg
5 mg
10 mg
50 mg
原价
470
998
1600
4320
售价
470
998
1600
4320
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM, >40- and >800-fold versus JAK1 and TYK2.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    55 mg/kg每天两次,口服给药

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Stump KL, et al. Arthritis Res Ther, 2011, 13(2), R68.

    分子式
    C24H26N6O2S
    分子量
    462.57
    CAS号
    1257704-57-6
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    200 mM
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02125500 Viral Hepatitis C|HIV Drug: Sofosbuvir/Ledipasvir fixed dose French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) Phase 2 2014-09-01 2016-01-04
    NCT02478229 Hepatitis C Viral Infection Drug: Sofosbuvir (SOF) and Ledipasvir (LDV) University Health Network, Toronto Phase 3 2015-06-01 2016-08-04
    NCT02638233 Chronic Hepatitis C Drug: Sofosbuvir 400mg / Ledipasvir 90 mg (FDC) Wilhelminenspital Vienna|Gilead Sciences Phase 4 2015-09-01 2015-12-18
    NCT02705534 Hepatitis C|Cirrhosis Drug: Sofosbuvir|Drug: Ledipasvir|Drug: Ribavirin Tehran University of Medical Sciences|Bakhtar Bioshimi Co Phase 3 2016-09-01 2016-07-03
    NCT02683005 Hepatitis C|Pregnancy Drug: ledipasvir/sofosbuvir University of Pittsburgh|Gilead Sciences|University of Nebraska Phase 1 2016-09-01 2016-11-17
    NCT02836925 Indolent B-cell Lymphoma|Hepatitis C Drug: Sofosbuvir+Ledipasvir|Drug: Sofosbuvir+Ribavirin|Drug: Sofosbuvir+Ledipasvir+Ribavirin Fondazione Italiana Linfomi ONLUS Phase 2 2016-03-01 2016-09-20
    NCT02421211 Hepatitis C, Chronic Drug: Simeprevir (SMV)|Drug: Ledipasvir (LDV)|Drug: Sofosbuvir (SOF) Janssen Sciences Ireland UC Phase 2 2015-05-01 2016-11-07
    NCT03061032 Hepatitis C Drug: Sofosbuvir/Ledipasvir 12W|Drug: Sofosbuvir/Ledipasvir plus Ribavirin 12W|Drug: Sofosbuvir/Ledipasvir 24W|Drug: Sofosbuvir/Ledipasvir plus Ribavirin 24W Iran Hepatitis Network|Baqiyatallah Research Center for Gastroenterology and Liver Diseases Phase 3 2017-03-01 2017-02-17
    NCT01924949 Hepatitis C Drug: LDV/SOF Gilead Sciences Phase 2 2013-07-01 2015-05-13
    NCT02405013 Hepatitis C|HIV Infection Drug: Sofosbuvir|Drug: Ribavirin|Drug: Sofosbuvir|Drug: Ledipasvir French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) Phase 2 2015-10-01 2017-01-11
    NCT02472886 Hepatitis C Infection Drug: LDV/SOF|Drug: RBV Gilead Sciences Phase 3 2015-06-01 2016-07-05
    NCT02301936 Hepatitis C Virus Infection Drug: LDV/SOF Gilead Sciences Phase 2 2015-03-01 2016-04-26
    NCT02350569 Hepatitis C Virus Infection Drug: LDV/SOF Gilead Sciences Phase 2 2015-05-01 2016-04-26
    NCT02480387 Treatment of Hepatitis C Drug: Ledipasvir/Sofosbuvir FDC Peter J. Ruane, M.D., Inc. Phase 2 2015-05-01 2016-07-19
    NCT02600351 Hepatitis C Virus Infection Drug: LDV/SOF|Drug: RBV Gilead Sciences Phase 3 2015-11-01 2016-07-01
    NCT01984294 Chronic HCV Infection Drug: LDV/SOF|Drug: RBV|Drug: GS-9669 Gilead Sciences Phase 2 2013-10-01 2015-04-30
    NCT02251717 Hepatitis C Virus Infection Drug: LDV/SOF Gilead Sciences Phase 2 2014-10-01 2016-07-15
    NCT03005210 Healthy Drug: Magicbuvir Plus|Drug: Harvoni (fist dose)|Drug: Harvoni (second dose) Genuine Research Center, Egypt|Magic Pharma, Egypt Phase 1 2016-11-01 2016-12-28
    NCT02487030 Hepatitis C Virus Infection Drug: LDV/SOF|Drug: RBV Gilead Sciences Phase 3 2015-09-07 2017-02-21
    NCT02413593 Hepatitis C Virus Infection Drug: LDV/SOF|Drug: RBV Gilead Sciences Phase 2 2015-04-01 2016-12-22

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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