化合物Acetylcholine Chloride是一种神经递质,作用于包括人类在内的许多生物的周围神经系统(PNS)和中枢神经系统(CNS)。
The chemical compound Acetylcholine Chloride is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Pepeu, G. and Blandina, P. 1998. J. Physiol. Paris. 92: 351-355. PMID: 9789836
[2] Perry, E., et al. 1999. Trends Neurosci. 22: 273-280. PMID: 10354606
[3] Lei, X., et al. 2008. Arch. Dermatol. Res. 300: 335-341. PMID: 18386025
分子式 C7H16NO2.Cl |
分子量 181.66 |
CAS号 60-31-1 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 30 mg/mL |
Water <1 mg/mL |
Ethanol 30 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01137656 | Healthy | Drug: Acetylcholine and Blood | Mark Gladwin|National Heart, Lung, and Blood Institute (NHLBI)|University of Pittsburgh | Phase 1 | 2010-04-01 | 2015-04-10 |
NCT01098383 | Autism | Drug: Acetyl-Choline Esterase Inhibitors and Choline supplements|Drug: Indistinguishable placebo tablets, matching both donepezil and choline | Sheba Medical Center|The Israeli Society of Clinical Pediatrics (HIPAK) | Phase 4 | 2010-03-01 | 2016-10-13 |
NCT00350532 | Pain | Drug: clonidine|Drug: clonidine | Wake Forest University Health Sciences|National Institute of Neurological Disorders and Stroke (NINDS) | Phase 2 | 2004-09-01 | 2014-03-05 |
NCT02063542 | Necrosis of Femoral Head|Knee Osteoarthritis|Fracture of Lower Limb | RenJi Hospital | 2014-04-01 | 2014-05-27 | ||
NCT01242306 | Endothelial Dysfunction | Drug: intracoronary infusion of acetylcholine | Azienda Ospedaliera San Camillo Forlanini | Phase 1|Phase 2 | 2009-03-01 | 2010-11-16 |
NCT01894646 | Measure of Uptake of XTRA in the Brain. | Radiation: Positron Emission Tomagraphy (PET) Imaging | Johns Hopkins University|National Institutes of Health (NIH) | 2013-02-01 | 2015-03-30 | |
NCT00921856 | Coronary Vasospasm|Microvascular Angina|Coronary Artery Disease | Other: Intracoronary acetylcholine provocation test | Peter Ong, MD|Robert Bosch Medical Center | 2007-11-01 | 2015-11-02 | |
NCT02008292 | Smoking|Schizophrenia | Drug: Physostigmine | Yale University|National Institutes of Health (NIH)|National Institute on Drug Abuse (NIDA) | 2013-09-01 | 2016-12-15 | |
NCT02645461 | Amyotrophic Lateral Sclerosis | Drug: endocannabinoid palmitoylethanolamide (PEA)|Drug: Riluzole | University of Roma La Sapienza | 2014-01-01 | 2016-01-01 | |
NCT01046513 | Healthy Volunteers|Nicotine Dependence|Pharmacokinetics | National Institute on Drug Abuse (NIDA)|National Institutes of Health Clinical Center (CC) | 2007-08-31 | 2017-01-24 | ||
NCT00987220 | Alzheimer's Disease|Dementia | Drug: Placebo|Drug: donepezil (Aricept) | Pfizer | 2009-10-01 | 2011-02-10 | |
NCT01848301 | Cardiac Allograft Vasculopathy|Antibody Mediated Rejection | Device: Optical Coherence Tomography|Drug: Acetylcholine|Procedure: Brachial Artery Flow Mediated Dilation | University of Pittsburgh | Phase 1 | 2012-09-01 | 2016-01-08 |
NCT01162824 | Endothelial Dysfunction|Atherosclerosis|Inflammation|Myocardial Ischemia | Drug: Acetylcholine|Drug: Adenosine | St George's Healthcare NHS Trust | 2011-01-01 | 2011-02-22 | |
NCT02085317 | Lepromatous Leprosy | Drug: acetylcholine Iontophoresis|Drug: sodium nitroprusside Iontophoresis | Curt Treu|Rio de Janeiro State University | 2006-03-01 | 2014-03-10 | |
NCT00259701 | Diabetes|Retinopathy|Vascular Pathology | Device: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin | Yale University | 2005-06-01 | 2006-10-05 | |
NCT00061789 | Schizophrenia | Drug: SPECT Imaging of Nicotinic Acetylcholine Receptors in Brain | National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2003-02-01 | 2008-03-03 |
NCT00917709 | Dementia With Lewy Bodies | Other: Imaging with IBVM|Other: Imaging with DATSCAN|Behavioral: neuropsychological evaluation | University Hospital, Bordeaux | 2009-05-01 | 2014-08-20 | |
NCT02138708 | Pulmonary Arterial Hypertension With Congenital Cardiac Shunt | Other: Pharmacological test of pulmonary endothelial | Assistance Publique - H么pitaux de Paris | 2016-01-01 | 2015-07-20 | |
NCT00184847 | Ischemia-Reperfusion Injury | Drug: acetylcholine|Procedure: twenty minutes of forearm ischemia|Procedure: three 5-minute periods of forearm ischemia|Drug: adenosine|Drug: caffeine | Radboud University | 2005-03-01 | 2008-03-27 | |
NCT02034331 | Spinal Cord Injury|Insulin Resistance | Drug: Insulin iontophoresis|Drug: Placebo Iontophoresis|Drug: Acetylcholine Iontophoresis|Other: Heat application | James J. Peters Veterans Affairs Medical Center | 2012-12-01 | 2017-03-06 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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