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Miconazole Nitrate

硝酸咪康唑,NSC 169434 Nitrate,NSC-169434 Nitrate,NSC169434 Nitrate,

Miconazole nitrate是咪唑类抗真菌剂。

目录号
EY1137
EY1137
EY1137
纯度
99.26%
99.26%
99.26%
规格
500 mg
1 g
5 g
原价
320
435
930
售价
320
435
930
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Miconazole Nitrate is an imidazole antifungal agent by inhibiting ergosterol biosynthesis and inducing ROS, used to treat vaginal yeast infections.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Thevissen K, et al. J Biol Chem,?007, 282(30), 21592-21597.

    分子式
    C18H15Cl4N3O4
    分子量
    479.14
    CAS号
    22832-87-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    96 mg/mL
    Water
    <1 mg/mL
    Ethanol
    3 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02215395 Antifungal Drug Adverse Reaction Drug: NES/EE CVR Population Council Phase 1 2014-03-01 2015-04-10
    NCT00702507 Diaper Rash Drug: 0.25 % Miconazole Nitrate Ointment Stiefel, a GSK Company|GlaxoSmithKline Phase 4 2007-05-01 2012-03-22
    NCT01230814 Bacterial Vaginosis|Candidiasis|Trichomoniasis Drug: Neo-Penotran Forte (active ingredient Metronidazole & Miconazole Nitrate)|Drug: Placebo National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2011-04-01 2014-09-26
    NCT01731574 HIV Drug: dapivirine|Drug: miconazole International Partnership for Microbicides, Inc. Phase 1 2012-12-01 2013-11-06
    NCT01661556 Melasma Drug: Miconazole|Drug: Hydroquinone Universidad Autonoma de San Luis Potos|Hospital Central "Dr. Ignacio Morones Prieto" Phase 4 2011-10-01 2014-12-01
    NCT00668538 Healthy Drug: Brentan (miconazole) University of Southern Denmark|Odense University Hospital 2008-04-01 2008-10-16
    NCT01439646 Antifungal Therapy Other: it is a retrospective study, hence no active intervention Fortis Hospital, India|Merck Sharp & Dohme Corp. 2011-08-01 2015-08-11
    NCT00936910 Central Line Fungal Infections Drug: amphotericin B liposomal (Ambisome) University of Pittsburgh|Astellas Pharma Inc Phase 4 2006-09-01 2016-01-12
    NCT00386802 Invader Fungal Infection Drug: Antifungal drug. VORICONAZOL. (VFEND) PETHEMA Foundation Phase 4 2006-08-01 2009-09-17
    NCT00390780 HIV Infections Drug: miconazole Lauriad|Drug: Clotrimazole Onxeo Phase 3 2006-07-01 2013-09-05
    NCT01524432 Tinea Pedis Drug: Anti-fungal agent (Clotrimazole) loaded microcapsules|Drug: Placebo Prof. Yuen Chun-Wah|Dr. Cheung Hing Cheong Private Dermatology Clinic|The Hong Kong Polytechnic University Phase 1 2012-01-01 2013-03-31
    NCT01686607 Systemic Fungal Infections Drug: Parenteral micafungin application|Drug: Other parenteral antifungal drugs Astellas Pharma Europe B.V.|World Health Information Science Consultants, LLC|Astellas Pharma Inc 2012-10-01 2017-02-28
    NCT02154178 Fungal Infection|Critical Illness Other: Biomarker group University Hospital, Lille 2014-07-01 2017-03-22
    NCT01580878 Tinea Pedis Drug: Butenafine Hydrochloride Cream, 1%|Drug: Lotrimin Ultra|Drug: Butenafine Vehicle Taro Pharmaceuticals USA Phase 1 2012-01-01 2014-01-19
    NCT03090334 Invasive Candidiases|Abdominal Infection Diagnostic Test: De-escalation University of Bologna 2017-03-01 2017-03-18
    NCT00906633 Fungal Infection University Hospital, Udine, Italy|Catholic University of the Sacred Heart 2009-01-01 2010-01-25
    NCT02818803 Candidiasis, Oral|Stomatitis, Denture Other: Propolis|Drug: Miconazole University of Sao Paulo|Financiadora de Estudos e Projetos Phase 3 2016-01-01 2016-06-27
    NCT02184351 Candidiasis, Oral Drug: Roxanes's clotrimazole troches|Drug: Mycelextroches Boehringer Ingelheim Phase 3 2001-05-01 2014-07-11
    NCT01769339 Vulva; Candidiasis Drug: Miconazole plus Hydrocortisone Janssen Pharmaceutica Phase 4 2009-01-01 2013-02-18
    NCT01869829 Pediatric Invasive Candidiasis Drug: Observational antifungal therapy Duke University|Children's Hospital of Philadelphia|National Institute of Allergy and Infectious Diseases (NIAID) 2013-07-01 2016-07-20
    NCT00004575 Healthy Drug: Miconazole, L-NMMA, Bradykinin National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Phase 1 2000-02-01 2008-03-03

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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