Miconazole nitrate是咪唑类抗真菌剂。
Miconazole Nitrate is an imidazole antifungal agent by inhibiting ergosterol biosynthesis and inducing ROS, used to treat vaginal yeast infections.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Thevissen K, et al. J Biol Chem,?007, 282(30), 21592-21597.
分子式 C18H15Cl4N3O4 |
分子量 479.14 |
CAS号 22832-87-7 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 96 mg/mL |
Water <1 mg/mL |
Ethanol 3 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02215395 | Antifungal Drug Adverse Reaction | Drug: NES/EE CVR | Population Council | Phase 1 | 2014-03-01 | 2015-04-10 |
NCT00702507 | Diaper Rash | Drug: 0.25 % Miconazole Nitrate Ointment | Stiefel, a GSK Company|GlaxoSmithKline | Phase 4 | 2007-05-01 | 2012-03-22 |
NCT01230814 | Bacterial Vaginosis|Candidiasis|Trichomoniasis | Drug: Neo-Penotran Forte (active ingredient Metronidazole & Miconazole Nitrate)|Drug: Placebo | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 | 2011-04-01 | 2014-09-26 |
NCT01731574 | HIV | Drug: dapivirine|Drug: miconazole | International Partnership for Microbicides, Inc. | Phase 1 | 2012-12-01 | 2013-11-06 |
NCT01661556 | Melasma | Drug: Miconazole|Drug: Hydroquinone | Universidad Autonoma de San Luis Potos|Hospital Central "Dr. Ignacio Morones Prieto" | Phase 4 | 2011-10-01 | 2014-12-01 |
NCT00668538 | Healthy | Drug: Brentan (miconazole) | University of Southern Denmark|Odense University Hospital | 2008-04-01 | 2008-10-16 | |
NCT01439646 | Antifungal Therapy | Other: it is a retrospective study, hence no active intervention | Fortis Hospital, India|Merck Sharp & Dohme Corp. | 2011-08-01 | 2015-08-11 | |
NCT00936910 | Central Line Fungal Infections | Drug: amphotericin B liposomal (Ambisome) | University of Pittsburgh|Astellas Pharma Inc | Phase 4 | 2006-09-01 | 2016-01-12 |
NCT00386802 | Invader Fungal Infection | Drug: Antifungal drug. VORICONAZOL. (VFEND) | PETHEMA Foundation | Phase 4 | 2006-08-01 | 2009-09-17 |
NCT00390780 | HIV Infections | Drug: miconazole Lauriad|Drug: Clotrimazole | Onxeo | Phase 3 | 2006-07-01 | 2013-09-05 |
NCT01524432 | Tinea Pedis | Drug: Anti-fungal agent (Clotrimazole) loaded microcapsules|Drug: Placebo | Prof. Yuen Chun-Wah|Dr. Cheung Hing Cheong Private Dermatology Clinic|The Hong Kong Polytechnic University | Phase 1 | 2012-01-01 | 2013-03-31 |
NCT01686607 | Systemic Fungal Infections | Drug: Parenteral micafungin application|Drug: Other parenteral antifungal drugs | Astellas Pharma Europe B.V.|World Health Information Science Consultants, LLC|Astellas Pharma Inc | 2012-10-01 | 2017-02-28 | |
NCT02154178 | Fungal Infection|Critical Illness | Other: Biomarker group | University Hospital, Lille | 2014-07-01 | 2017-03-22 | |
NCT01580878 | Tinea Pedis | Drug: Butenafine Hydrochloride Cream, 1%|Drug: Lotrimin Ultra|Drug: Butenafine Vehicle | Taro Pharmaceuticals USA | Phase 1 | 2012-01-01 | 2014-01-19 |
NCT03090334 | Invasive Candidiases|Abdominal Infection | Diagnostic Test: De-escalation | University of Bologna | 2017-03-01 | 2017-03-18 | |
NCT00906633 | Fungal Infection | University Hospital, Udine, Italy|Catholic University of the Sacred Heart | 2009-01-01 | 2010-01-25 | ||
NCT02818803 | Candidiasis, Oral|Stomatitis, Denture | Other: Propolis|Drug: Miconazole | University of Sao Paulo|Financiadora de Estudos e Projetos | Phase 3 | 2016-01-01 | 2016-06-27 |
NCT02184351 | Candidiasis, Oral | Drug: Roxanes's clotrimazole troches|Drug: Mycelextroches | Boehringer Ingelheim | Phase 3 | 2001-05-01 | 2014-07-11 |
NCT01769339 | Vulva; Candidiasis | Drug: Miconazole plus Hydrocortisone | Janssen Pharmaceutica | Phase 4 | 2009-01-01 | 2013-02-18 |
NCT01869829 | Pediatric Invasive Candidiasis | Drug: Observational antifungal therapy | Duke University|Children's Hospital of Philadelphia|National Institute of Allergy and Infectious Diseases (NIAID) | 2013-07-01 | 2016-07-20 | |
NCT00004575 | Healthy | Drug: Miconazole, L-NMMA, Bradykinin | National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) | Phase 1 | 2000-02-01 | 2008-03-03 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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