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Capreomycin Sulfate

硫酸卷曲霉素

Capreomycin Sulfate是一种环状多肽类抗生素,通过与70S核糖体结合,从而抑制蛋白合成。

目录号
EY1130
EY1130
EY1130
纯度
99.46%
99.46%
99.46%
规格
500 mg
1 g
5 g
原价
760
1200
3500
售价
760
1200
3500
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Capreomycin Sulfate is a cyclic peptide antibiotic and thought to inhibit protein synthesis by binding to the 70S ribosomal unit.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Stokowa K, et al. J Inorg Biochem, 2012, 106(1), 111-116.

    分子式
    C25H44N14O7.H2SO4
    分子量
    750.78
    CAS号
    1405-37-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    100 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02169141 Tuberculosis Other: Pharmacokinetics University Medical Center Groningen|Republican Scientific and Practical Centre for Pulmonology and TB|National Institute for Public Health and the Environment (RIVM) 2012-11-01 2014-06-20
    NCT02236078 Tuberculosis|Drug-resistant Tuberculosis|Multidrug-resistant Tuberculosis Drug: Capreomycin|Drug: High dose isoniazid|Drug: Rifampicin|Drug: Rifabutin|Drug: Moxifloxacin Centers for Disease Control and Prevention|Kenya Medical Research Institute 2015-11-01 2016-07-25
    NCT01464762 Tuberculosis Drug: TMC207 Janssen Infectious Diseases BVBA null 2017-01-30
    NCT00000796 HIV Infections|Tuberculosis Drug: Cycloserine|Drug: Ethionamide|Drug: Capreomycin sulfate|Drug: Aminosalicylic acid|Drug: Streptomycin sulfate|Drug: Ethambutol hydrochloride|Drug: Amikacin sulfate|Drug: Isoniazid|Drug: Pyrazinamide|Drug: Pyridoxine hydrochloride|Drug: Levofloxacin|Drug: Rifampin|Drug: Clofazimine National Institute of Allergy and Infectious Diseases (NIAID) null 2012-03-30
    NCT02496572 Multidrug Resistant Tuberculosis Drug: Short course MDR-TB treatment regimen Medecins Sans Frontieres, Netherlands|Ministry of Health, Republic of Uzbekistan|Imperial College London Phase 3 2013-09-01 2015-07-09
    NCT00042289 HIV Infections Drug: atazanavir/cobicistat|Drug: darunavir/ritonavir|Drug: darunavir/cobicistat|Drug: etravirine|Drug: elvitegravir/cobicistat|Drug: dolutegravir|Drug: tenofovir alafenamide fumarate (TAF)|Drug: TAF/cobicistat|Drug: TAF/ritonavir|Drug: efavirenz|Drug: lopinavir/ritonavir|Drug: nevirapine|Drug: rifampicin|Drug: ethambutol|Drug: isoniazid|Drug: pyrazinamide|Drug: rifampicin|Drug: kanamycin|Drug: amikacin|Drug: capreomycin|Drug: moxifloxacin|Drug: levofloxacin|Drug: ofloxacin|Drug: ethionamide/prothionamide|Drug: terizidone/cycloserine|Drug: para-aminosalicylic acid (PAS)|Drug: high dose isoniazid (INH)|Drug: bedaquiline|Drug: clofazamine|Drug: delamanid|Drug: linezolid|Drug: pretomanid|Drug: atazanavir/ritonavir/tenofovir|Drug: ethinyl estradiol oral contraceptive|Drug: etonogestrel implant National Institute of Allergy and Infectious Diseases (NIAID)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 4 2003-03-01 2017-03-13
    NCT02099240 Osteomyelitis Drug: oral antibiotics|Procedure: intravenous antibiotics Julio Ramirez|James Graham Brown Cancer Center|University of Louisville Early Phase 1 2014-04-01 2017-03-21

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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