Capreomycin Sulfate是一种环状多肽类抗生素,通过与70S核糖体结合,从而抑制蛋白合成。
Capreomycin Sulfate is a cyclic peptide antibiotic and thought to inhibit protein synthesis by binding to the 70S ribosomal unit.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Stokowa K, et al. J Inorg Biochem, 2012, 106(1), 111-116.
分子式 C25H44N14O7.H2SO4 |
分子量 750.78 |
CAS号 1405-37-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water 100 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02169141 | Tuberculosis | Other: Pharmacokinetics | University Medical Center Groningen|Republican Scientific and Practical Centre for Pulmonology and TB|National Institute for Public Health and the Environment (RIVM) | 2012-11-01 | 2014-06-20 | |
NCT02236078 | Tuberculosis|Drug-resistant Tuberculosis|Multidrug-resistant Tuberculosis | Drug: Capreomycin|Drug: High dose isoniazid|Drug: Rifampicin|Drug: Rifabutin|Drug: Moxifloxacin | Centers for Disease Control and Prevention|Kenya Medical Research Institute | 2015-11-01 | 2016-07-25 | |
NCT01464762 | Tuberculosis | Drug: TMC207 | Janssen Infectious Diseases BVBA | null | 2017-01-30 | |
NCT00000796 | HIV Infections|Tuberculosis | Drug: Cycloserine|Drug: Ethionamide|Drug: Capreomycin sulfate|Drug: Aminosalicylic acid|Drug: Streptomycin sulfate|Drug: Ethambutol hydrochloride|Drug: Amikacin sulfate|Drug: Isoniazid|Drug: Pyrazinamide|Drug: Pyridoxine hydrochloride|Drug: Levofloxacin|Drug: Rifampin|Drug: Clofazimine | National Institute of Allergy and Infectious Diseases (NIAID) | null | 2012-03-30 | |
NCT02496572 | Multidrug Resistant Tuberculosis | Drug: Short course MDR-TB treatment regimen | Medecins Sans Frontieres, Netherlands|Ministry of Health, Republic of Uzbekistan|Imperial College London | Phase 3 | 2013-09-01 | 2015-07-09 |
NCT00042289 | HIV Infections | Drug: atazanavir/cobicistat|Drug: darunavir/ritonavir|Drug: darunavir/cobicistat|Drug: etravirine|Drug: elvitegravir/cobicistat|Drug: dolutegravir|Drug: tenofovir alafenamide fumarate (TAF)|Drug: TAF/cobicistat|Drug: TAF/ritonavir|Drug: efavirenz|Drug: lopinavir/ritonavir|Drug: nevirapine|Drug: rifampicin|Drug: ethambutol|Drug: isoniazid|Drug: pyrazinamide|Drug: rifampicin|Drug: kanamycin|Drug: amikacin|Drug: capreomycin|Drug: moxifloxacin|Drug: levofloxacin|Drug: ofloxacin|Drug: ethionamide/prothionamide|Drug: terizidone/cycloserine|Drug: para-aminosalicylic acid (PAS)|Drug: high dose isoniazid (INH)|Drug: bedaquiline|Drug: clofazamine|Drug: delamanid|Drug: linezolid|Drug: pretomanid|Drug: atazanavir/ritonavir/tenofovir|Drug: ethinyl estradiol oral contraceptive|Drug: etonogestrel implant | National Institute of Allergy and Infectious Diseases (NIAID)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 4 | 2003-03-01 | 2017-03-13 |
NCT02099240 | Osteomyelitis | Drug: oral antibiotics|Procedure: intravenous antibiotics | Julio Ramirez|James Graham Brown Cancer Center|University of Louisville | Early Phase 1 | 2014-04-01 | 2017-03-21 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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