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Tolnaftate

托萘酯

Tolnaftate是合成的硫代氨基甲酸酯类抗真菌化合物。

目录号
EY1127
EY1127
EY1127
纯度
99.34%
99.34%
99.34%
规格
500 mg
1 g
5 g
原价
320
450
1100
售价
320
450
1100
库存
现货
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] J Pannu et. Al. Antimicrobial Agents and Chemotherapy, 53(8), 3273-3279 (2009).
    [2] H Vanden Bossche et. Al. Journal of Veterinary Pharmacology and Therapeutics, 26(1), 5-29 (2003).

    分子式
    C19H17NOS
    分子量
    307.41
    CAS号
    2398-96-1
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    62 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01105013 Fungal Infections|Tinea Pedis|Tinea Cruris|Tinea Corporis Drug: Clotrimazole Laboratrio Teuto Brasileiro S/A Phase 3 2012-04-01 2012-04-11
    NCT02600936 Peripheral Venous Outflow Obstruction Device: vein stent placement Windsor Ting|Boston Scientific Corporation|Icahn School of Medicine at Mount Sinai 2017-06-01 2016-12-13
    NCT01429701 Eczema Drug: polymyxin B sulphate + prednisolone + benzocaine + clioquinol|Drug: betamethasone + gentamicin + tolnaftato + cleoquinol EMS Phase 3 2012-05-01 2013-03-01
    NCT02169258 Peripheral Artery Disease|Coronary Artery Disease Procedure: Systemic Strategy National Cheng-Kung University Hospital|Tainan Municipal Hospital|E-DA Hospital|Kaohsiung Medical University|National Taiwan University Hospital|Buddhist Tzu Chi General Hospital|Far Eastern Memorial Hospital|University of Alberta 2014-06-01 2015-09-23
    NCT02084277 Malocclusion Device: Self-ligating brackets (SLB)|Device: Conventional brackets (CB) Mackay Memorial Hospital 2010-06-01 2014-03-09
    NCT01281683 Hepatocellular Carcinoma National Taiwan University Hospital 2011-01-01 2011-01-20
    NCT01412476 Metabolic Syndrome Chung Shan Medical University|National Science Council, Taiwan 2010-08-01 2012-03-23
    NCT01273701 Amphetamine Abuse|Amphetamine Dependence|Methamphetamine Abuse|Methamphetamine Dependence Behavioral: Psychosocial intervention|Behavioral: Telephone reminding National Taiwan University Hospital 2011-01-01 2011-01-06
    NCT02574065 Crying Time in Colicky Infants Drug: L. reuteri DSM 17938|Other: The placebo consists of an identical formulation without L. reuteri DSM 17938 Shanghai Children's Hospital|BioGaia AB|Suzhou University Affiliated Children's Hospital|Shanghai Children's Medical Center 2016-03-01 2016-10-27
    NCT01974505 Intubation, Intratracheal Device: intubation using optiscope Jeju National University School of Medicine 2013-11-01 2013-10-28
    NCT00695110 Hypogonadism Drug: Testosterone undecanoate (TU)|Drug: TU + testosterone enanthate (TE)|Drug: Testosterone undecanoate (TU)|Drug: TU + testosterone enanthate (TE) Clarus Therapeutics, Inc.|Los Angeles Biomedical Research Institute Phase 2 2008-06-01 2010-08-23
    NCT02995707 Thalassemia Drug: Thalidomide Xiao-Lin Yin|303rd Hospital of the People's Liberation Army Phase 2 2016-09-01 2017-03-21
    NCT03090516 Alzheimer's Drug: Ginkgo biloba dispersible tablets|Drug: Donepezil|Drug: Ginkgo biloba dispersible tablets and Donepezil The First Affiliated Hospital with Nanjing Medical University Phase 2|Phase 3 2016-08-10 2017-03-23
    NCT02815163 Empowerment Other: Empowerment education Tzu-Ting Huang|Chang Gung Memorial Hospital 2013-09-01 2016-06-27
    NCT00314301 Cerebral Palsy Device: loaded sit-to-stand training Far Eastern Memorial Hospital|National Taiwan University 2006-04-01 2006-04-14
    NCT00172562 Acute Myeloid Leukemia National Taiwan University Hospital Phase 3
    2006-02-28
    NCT00172315 Acquired Immunodeficiency Syndrome|Lipodystrophy National Taiwan University Hospital Phase 3 2003-12-01 2006-03-28
    NCT01937429 Adenoma Detection to Prevent Colorectal Cancer Device: Colonoscopy with blue Indigo Carmin|Device: Standard colonoscopy with insufflation of air Hospices Civils de Lyon Phase 3 2013-01-01 2013-09-06
    NCT00924612 Male Hypogonadism Drug: Oral testosterone undecanoate (containing 300 mg of T) Clarus Therapeutics, Inc. Phase 2 2009-07-01 2010-08-23
    NCT00911586 Male Hypogonadism|Primary Hypogonadism|Secondary Hypogonadism Drug: Testosterone undecanoate Clarus Therapeutics, Inc. Phase 2 2009-07-01 2010-08-17

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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