MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂,抑制Syk, Src和p97, IC50分别为2.5 μM, 29.3 μM和1.7 μM。
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Wang WY, et al. Mol Pharmacol, 2006, 70(4), 1380-1389.
分子式 C9H7NO4 |
分子量 193.16 |
CAS号 1485-00-3 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 40 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00474799 | Healthy | Drug: MNS075 | Javelin Pharmaceuticals | Phase 1 | 2007-01-01 | 2008-01-11 |
NCT02534519 | Genetic Blood Group (bg) Polymorphism in U Negativity and St(a) of MNSs | Other: Whole Genome Sequencing (WGS) | Blood Donation Service Zurich, SRC | 2015-07-01 | 2015-08-24 | |
NCT02278068 | Diabetes|Endocrine, Nutritional and Metabolic Diseases (E00-E89) | Device: Metabolic Neuromodulation System (MNS) | Metavention | 2014-10-01 | 2017-03-21 | |
NCT00390039 | Pain, Postoperative | Drug: Intranasal Morphine|Drug: Placebo|Drug: IV morphine|Drug: Placebo|Drug: Intranasal morphine|Drug: Placebo | Javelin Pharmaceuticals | Phase 3 | 2006-05-01 | 2008-01-11 |
NCT02971371 | Stroke | Device: Lokomat | IRCCS Centro Neurolesi "Bonino-Pulejo" | 2015-10-01 | 2016-11-19 | |
NCT00388011 | Hallux Valgus | Drug: Intranasal Morphine (MNS075) 3.75 mg|Drug: Intravenous Morphine 7.5 mg|Drug: Intranasal morphine (MNS075) 7.5 mg|Drug: Intranasal morphine (MNS075) 15 mg|Drug: Intranasal morphine (MNS075) 30 mg|Drug: Intranasal placebo | Javelin Pharmaceuticals | Phase 2 | 2005-01-01 | 2008-01-11 |
NCT00983450 | Stroke | Other: watching a normal walking clip|Other: watching walk backward clip | Hadassah Medical Organization | Phase 2 | 2009-10-01 | 2010-06-02 |
NCT02696512 | Brain Injury | Drug: Polypharmacy using FDA-approved products|Device: Median Nerve Stimulation (MNS)|Dietary Supplement: Nutraceutical Supplementation|Other: Standard of Care | International Brain Research Foundation | Phase 1|Phase 2 | 2016-03-01 | 2016-08-31 |
NCT02768428 | Cancer | Other: Video-Audio Media | Chulabhorn Hospital | 2015-10-01 | 2016-05-10 | |
NCT01461863 | Low Birth Weight | Dietary Supplement: Porridge protein calorie supplement|Dietary Supplement: multivitamin | Dartmouth-Hitchcock Medical Center|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Muhimbili University of Health and Allied Sciences | Phase 2|Phase 3 | 2011-10-01 | 2014-09-26 |
NCT01432288 | Central Nervous System | Wake Forest University|Wake Forest University Health Sciences | 2011-08-01 | 2012-03-09 | ||
NCT02235350 | Stroke, Acute Hemiplegia, Apraxia | Other: Action Observation Treatment (AOT)|Other: Observation of videos with no motor content (MNO) | Neuromed IRCCS | 2014-06-01 | 2014-09-09 | |
NCT01635153 | HIV|Tuberculosis | Dietary Supplement: Protein calorie supplement|Dietary Supplement: Micronutrient | Dartmouth-Hitchcock Medical Center|National Institutes of Health (NIH) | Phase 2 | 2012-05-01 | 2015-02-09 |
NCT00994331 | Coronary Artery Disease | Procedure: Percutaneous coronary intervention | Stereotaxis | 2009-10-01 | 2011-03-08 | |
NCT02914171 | Ebstein Anomaly | Biological: Autologous Bone Marrow-derived Mononuclear Cells|Device: Insertable cardiac monitor | Timothy J. Nelson|Mayo Clinic | Phase 1 | 2016-09-01 | 2016-10-05 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们