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MNS

3,4-Methylenedioxy-β-nitrostyrene,MDBN

MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂,抑制Syk, Src和p97, IC50分别为2.5 μM, 29.3 μM和1.7 μM。

目录号
EY1124
EY1124
纯度
99.65%
99.65%
规格
100 mg
500 mg
原价
478
1500
售价
478
1500
库存
现货
现货
订购
订购
订购
订购
订购
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  • 生物活性

    MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Wang WY, et al. Mol Pharmacol, 2006, 70(4), 1380-1389.

    分子式
    C9H7NO4
    分子量
    193.16
    CAS号
    1485-00-3
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    40 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00474799 Healthy Drug: MNS075 Javelin Pharmaceuticals Phase 1 2007-01-01 2008-01-11
    NCT02534519 Genetic Blood Group (bg) Polymorphism in U Negativity and St(a) of MNSs Other: Whole Genome Sequencing (WGS) Blood Donation Service Zurich, SRC 2015-07-01 2015-08-24
    NCT02278068 Diabetes|Endocrine, Nutritional and Metabolic Diseases (E00-E89) Device: Metabolic Neuromodulation System (MNS) Metavention 2014-10-01 2017-03-21
    NCT00390039 Pain, Postoperative Drug: Intranasal Morphine|Drug: Placebo|Drug: IV morphine|Drug: Placebo|Drug: Intranasal morphine|Drug: Placebo Javelin Pharmaceuticals Phase 3 2006-05-01 2008-01-11
    NCT02971371 Stroke Device: Lokomat IRCCS Centro Neurolesi "Bonino-Pulejo" 2015-10-01 2016-11-19
    NCT00388011 Hallux Valgus Drug: Intranasal Morphine (MNS075) 3.75 mg|Drug: Intravenous Morphine 7.5 mg|Drug: Intranasal morphine (MNS075) 7.5 mg|Drug: Intranasal morphine (MNS075) 15 mg|Drug: Intranasal morphine (MNS075) 30 mg|Drug: Intranasal placebo Javelin Pharmaceuticals Phase 2 2005-01-01 2008-01-11
    NCT00983450 Stroke Other: watching a normal walking clip|Other: watching walk backward clip Hadassah Medical Organization Phase 2 2009-10-01 2010-06-02
    NCT02696512 Brain Injury Drug: Polypharmacy using FDA-approved products|Device: Median Nerve Stimulation (MNS)|Dietary Supplement: Nutraceutical Supplementation|Other: Standard of Care International Brain Research Foundation Phase 1|Phase 2 2016-03-01 2016-08-31
    NCT02768428 Cancer Other: Video-Audio Media Chulabhorn Hospital 2015-10-01 2016-05-10
    NCT01461863 Low Birth Weight Dietary Supplement: Porridge protein calorie supplement|Dietary Supplement: multivitamin Dartmouth-Hitchcock Medical Center|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Muhimbili University of Health and Allied Sciences Phase 2|Phase 3 2011-10-01 2014-09-26
    NCT01432288 Central Nervous System Wake Forest University|Wake Forest University Health Sciences 2011-08-01 2012-03-09
    NCT02235350 Stroke, Acute Hemiplegia, Apraxia Other: Action Observation Treatment (AOT)|Other: Observation of videos with no motor content (MNO) Neuromed IRCCS 2014-06-01 2014-09-09
    NCT01635153 HIV|Tuberculosis Dietary Supplement: Protein calorie supplement|Dietary Supplement: Micronutrient Dartmouth-Hitchcock Medical Center|National Institutes of Health (NIH) Phase 2 2012-05-01 2015-02-09
    NCT00994331 Coronary Artery Disease Procedure: Percutaneous coronary intervention Stereotaxis 2009-10-01 2011-03-08
    NCT02914171 Ebstein Anomaly Biological: Autologous Bone Marrow-derived Mononuclear Cells|Device: Insertable cardiac monitor Timothy J. Nelson|Mayo Clinic Phase 1 2016-09-01 2016-10-05

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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