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Cyclosporine

环孢霉素,环孢多肽

Cyclosporine 是一种calcineurin phosphatase 通路抑制剂,用作免疫抑制剂药物来组织器官移植中的免疫排斥。

目录号
EY1117
EY1117
纯度
99.53%
99.53%
规格
25 mg
50 mg
原价
490
920
售价
490
920
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Hojo M, et al. Nature, 1999, 397(6719), 530-534.

    分子式
    C62H111N11O12
    分子量
    1202.61
    CAS号
    79217-60-0
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    120 mg/mL warmed
    Water
    <1 mg/mL
    Ethanol
    120 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01693393 Sjgrens Syndrome Drug: Cyclosporine A Charite University, Berlin, Germany Phase 2 2010-03-01 2015-07-27
    NCT00332462 Liver Transplantation Drug: Cyclosporine (Sandimmun i.v.)|Drug: Cyclosporine (Sandimmun Optoral) Novartis Pharmaceuticals|Novartis Phase 4 2006-05-01 2011-03-01
    NCT01990898 Interstitial Cystitis Drug: Cyclosporine The Cleveland Clinic Phase 2 2013-11-01 2016-06-14
    NCT01768312 Dry Eye Syndromes Drug: Cyclosporine ophthalmic solution Hanlim Pharm. Co., Ltd. Phase 3 2012-03-01 2013-01-11
    NCT02144025 Graft-Versus-Host Disease Drug: Cyclosporine Hospital Universitario Dr. Jose E. Gonzalez Phase 2 2014-05-01 2016-02-25
    NCT01494597 Healthy Drug: isavuconazole|Drug: cyclosporine Astellas Pharma Inc|Basilea Pharmaceutica International Ltd Phase 1 2011-11-01 2011-12-16
    NCT00987467 Atopic Keratoconjunctivitis Drug: Cyclosporin 0.05% ophthalmic|Drug: Cyclosporin 0.05% ophthalmic Johns Hopkins University 2007-08-01 2013-10-04
    NCT00438360 Chronic Plaque Psoriasis Drug: Cyclosporine A microemulsion|Drug: Placebo Novartis Pharmaceuticals|Novartis Phase 3 2006-05-01 2011-07-13
    NCT01080586 Healthy Volunteers Drug: Cyclosporine Capsules USP (Modified) 100 mg Panacea Biotec Ltd 2007-09-01 2010-03-03
    NCT01080560 Healthy Volunteers Drug: Cyclosporine Capsules USP (Modified) 100 mg Panacea Biotec Ltd 2007-08-01 2010-03-03
    NCT00070291 Lymphoma Drug: cyclosporine Eastern Cooperative Oncology Group|National Cancer Institute (NCI) Phase 2 2005-09-01 2013-02-12
    NCT00050648 Psoriasis Drug: Daclizumab|Drug: Cyclosporine|Drug: cyclosporine and Daclizumab Rockefeller University|Facet Biotech Phase 1|Phase 2 1997-10-01 2009-03-12
    NCT00983424 Metastatic Breast Cancer Drug: Cyclosporins|Drug: nab-paclitaxel Northwestern University|Avon Foundation Phase 1 2010-02-01 2013-09-13
    NCT00375895 Chronic Hepatitis C|Evidence of Liver Transplantation Drug: ciclosporin Rennes University Hospital|Novartis Phase 3 2006-06-01 2012-03-01
    NCT02397213 Acute Kidney Injury Drug: Ciclosporin|Drug: Placebo Region Skane|NeuroVive Pharmaceutical AB Phase 2 2015-04-01 2016-10-12
    NCT00860496 Healthy Volunteers Drug: CP- 690,550 and Tacrolimus|Drug: CP- 690,550 and Cyclosporine Pfizer Phase 1 2009-06-01 2009-08-12
    NCT00919815 Leprosy Drug: Ciclosporin|Drug: Prednisolone London School of Hygiene and Tropical Medicine|Homes and Hospitals of St Giles|Alert Hospital, Ethiopia|Armauer Hansen Research Institute, Ethiopia Phase 2|Phase 3 2010-08-01 2015-03-21
    NCT00783107 Chronic Obstructive Pulmonary Disease Drug: Cyclosporine|Drug: Placebo University of Pittsburgh Phase 1 2007-10-01 2012-12-10
    NCT01762657 Type 1 Diabetes Drug: Oral Cyclosporine and Oral Lansoprazole|Drug: Placebos Perle Bioscience, Inc. Phase 3 2014-09-01 2016-04-17

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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