Cyclosporine 是一种calcineurin phosphatase 通路抑制剂,用作免疫抑制剂药物来组织器官移植中的免疫排斥。
Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Hojo M, et al. Nature, 1999, 397(6719), 530-534.
分子式 C62H111N11O12 |
分子量 1202.61 |
CAS号 79217-60-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 120 mg/mL warmed |
Water <1 mg/mL |
Ethanol 120 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01693393 | Sjgrens Syndrome | Drug: Cyclosporine A | Charite University, Berlin, Germany | Phase 2 | 2010-03-01 | 2015-07-27 |
NCT00332462 | Liver Transplantation | Drug: Cyclosporine (Sandimmun i.v.)|Drug: Cyclosporine (Sandimmun Optoral) | Novartis Pharmaceuticals|Novartis | Phase 4 | 2006-05-01 | 2011-03-01 |
NCT01990898 | Interstitial Cystitis | Drug: Cyclosporine | The Cleveland Clinic | Phase 2 | 2013-11-01 | 2016-06-14 |
NCT01768312 | Dry Eye Syndromes | Drug: Cyclosporine ophthalmic solution | Hanlim Pharm. Co., Ltd. | Phase 3 | 2012-03-01 | 2013-01-11 |
NCT02144025 | Graft-Versus-Host Disease | Drug: Cyclosporine | Hospital Universitario Dr. Jose E. Gonzalez | Phase 2 | 2014-05-01 | 2016-02-25 |
NCT01494597 | Healthy | Drug: isavuconazole|Drug: cyclosporine | Astellas Pharma Inc|Basilea Pharmaceutica International Ltd | Phase 1 | 2011-11-01 | 2011-12-16 |
NCT00987467 | Atopic Keratoconjunctivitis | Drug: Cyclosporin 0.05% ophthalmic|Drug: Cyclosporin 0.05% ophthalmic | Johns Hopkins University | 2007-08-01 | 2013-10-04 | |
NCT00438360 | Chronic Plaque Psoriasis | Drug: Cyclosporine A microemulsion|Drug: Placebo | Novartis Pharmaceuticals|Novartis | Phase 3 | 2006-05-01 | 2011-07-13 |
NCT01080586 | Healthy Volunteers | Drug: Cyclosporine Capsules USP (Modified) 100 mg | Panacea Biotec Ltd | 2007-09-01 | 2010-03-03 | |
NCT01080560 | Healthy Volunteers | Drug: Cyclosporine Capsules USP (Modified) 100 mg | Panacea Biotec Ltd | 2007-08-01 | 2010-03-03 | |
NCT00070291 | Lymphoma | Drug: cyclosporine | Eastern Cooperative Oncology Group|National Cancer Institute (NCI) | Phase 2 | 2005-09-01 | 2013-02-12 |
NCT00050648 | Psoriasis | Drug: Daclizumab|Drug: Cyclosporine|Drug: cyclosporine and Daclizumab | Rockefeller University|Facet Biotech | Phase 1|Phase 2 | 1997-10-01 | 2009-03-12 |
NCT00983424 | Metastatic Breast Cancer | Drug: Cyclosporins|Drug: nab-paclitaxel | Northwestern University|Avon Foundation | Phase 1 | 2010-02-01 | 2013-09-13 |
NCT00375895 | Chronic Hepatitis C|Evidence of Liver Transplantation | Drug: ciclosporin | Rennes University Hospital|Novartis | Phase 3 | 2006-06-01 | 2012-03-01 |
NCT02397213 | Acute Kidney Injury | Drug: Ciclosporin|Drug: Placebo | Region Skane|NeuroVive Pharmaceutical AB | Phase 2 | 2015-04-01 | 2016-10-12 |
NCT00860496 | Healthy Volunteers | Drug: CP- 690,550 and Tacrolimus|Drug: CP- 690,550 and Cyclosporine | Pfizer | Phase 1 | 2009-06-01 | 2009-08-12 |
NCT00919815 | Leprosy | Drug: Ciclosporin|Drug: Prednisolone | London School of Hygiene and Tropical Medicine|Homes and Hospitals of St Giles|Alert Hospital, Ethiopia|Armauer Hansen Research Institute, Ethiopia | Phase 2|Phase 3 | 2010-08-01 | 2015-03-21 |
NCT00783107 | Chronic Obstructive Pulmonary Disease | Drug: Cyclosporine|Drug: Placebo | University of Pittsburgh | Phase 1 | 2007-10-01 | 2012-12-10 |
NCT01762657 | Type 1 Diabetes | Drug: Oral Cyclosporine and Oral Lansoprazole|Drug: Placebos | Perle Bioscience, Inc. | Phase 3 | 2014-09-01 | 2016-04-17 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们