Clofibric Acid是PPARα激动剂,是一种降血脂剂。
Clofibric acid is a PPARα agonist and hypolipidemic agent.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Muerhoff AS, et al. J Biol Chem, 1992, 267(27), 19051-19053.
分子式 C10H11ClO3 |
分子量 214.65 |
CAS号 882-09-7 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 41 mg/mL |
Water <1 mg/mL |
Ethanol 41 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01527318 | Neutral Lipid Storage Disease | Drug: Fibrate treatment | Maastricht University Medical Center | Phase 4 | 2011-08-01 | 2013-05-13 |
NCT00243672 | Atherosclerosis | Drug: Atorvastatin|Drug: Gemfibrozil | University Hospital Muenster | Phase 4 | 2005-10-01 | 2007-11-16 |
NCT00491400 | Diabetes Mellitus|Metabolic Syndrome | Drug: Fenofibrate|Drug: Atorvastatin | Boston University | 2005-09-01 | 2012-09-24 | |
NCT00156169 | Low HDL Cholesterol | Drug: Dunaliella | Sheba Medical Center | Phase 3 | 2001-05-01 | 2009-08-10 |
NCT02530827 | HIV/AIDS|HIV Lipodystrophy Syndrome | Drug: use of lipid-lowering drugs. | University of Sao Paulo General Hospital|Fundao de Amparo Pesquisa do Estado de So Paulo | 2013-03-01 | 2015-08-20 | |
NCT00728910 | Dyslipidemia | Drug: Atorvastatin|Drug: ABT335|Drug: ER Niacin | University of Pennsylvania|Abbott | Phase 2 | 2008-06-01 | 2016-01-28 |
NCT01385020 | Healthy Subjects | Drug: Gemfibrozil & red yeast rice (LipoCol) | National Taiwan University Hospital|National Science Council, Taiwan | Phase 4 | 2011-07-01 | 2011-10-13 |
NCT01654731 | PBC | Drug: Bezafibrate|Drug: placebo | Assistance Publique - Hpitaux de Paris | Phase 3 | 2012-10-01 | 2017-02-20 |
NCT00458055 | Coronary Arteriosclerosis|Hypoalphalipoproteinemias|Genetic Diseases, Inborn | Drug: Atorvastatin; Fenofibrate; Niacin | McGill University Health Center | 2006-11-01 | 2008-06-02 | |
NCT01674712 | Dyslipidemia | Drug: Fixed Combination of Fenofibrate/simvastatin 145/20 mg|Drug: Simvastatin 20 mg|Drug: Fenofibrate 145 mg|Drug: Fixed Combination of Fenofibrate/simvastatin 145/40 mg|Drug: Simvastatin 40 mg | Abbott | Phase 3 | 2012-06-01 | 2014-11-24 |
NCT00965315 | Diabetes|CVD | Drug: Rosuvastatin,SFC fenofibrate | National Taiwan University Hospital | | 2012-12-20 | |
NCT01477944 | Hypercholesteremia | AstraZeneca | 2012-02-01 | 2012-02-20 | ||
NCT01148004 | HIV|Fenofibrate|Protease Inhibitors|Hypertriglyceridemia|Glucuronosyltransferase | Drug: Fenofibrate|Drug: Ritonavir|Drug: Lopinavir/Ritonavir | National Institutes of Health Clinical Center (CC) | Phase 1 | 2010-05-13 | 2017-02-01 |
NCT00037401 | Atherosclerosis|Cardiovascular Diseases|Hypercholesterolemia|Heart Diseases | National Heart, Lung, and Blood Institute (NHLBI) | 2001-09-01 | 2016-02-17 | ||
NCT01602913 | Depression, Postpartum | Drug: Pravastatin alone|Drug: Paroxetine alone|Drug: Pravastatin and paroxetine combined | GlaxoSmithKline | 2011-12-01 | 2014-06-30 | |
NCT01025492 | Dyslipidemia | Drug: Trilipix|Drug: placebo | University of Utah|Abbott | Phase 4 | 2009-11-01 | 2016-07-19 |
NCT00362206 | Hyperlipidemia | Drug: Fenofibrate/Simvastatin|Drug: Fenofibrate/Simvastatin|Drug: Pravastatin | Solvay Pharmaceuticals | Phase 3 | 2006-09-01 | 2009-07-07 |
NCT00352183 | Cardiovascular Diseases | Drug: Fenofibrate/Simvastatin|Drug: Simvastatin | Solvay Pharmaceuticals | Phase 3 | 2006-01-01 | 2009-07-07 |
NCT00349375 | Hyperlipidemia | Drug: Fenofibrate/Simvastatin|Drug: Fenofibrate/Simvastatin|Drug: Simvastatin | Solvay Pharmaceuticals | Phase 3 | 2005-11-01 | 2009-07-07 |
NCT01462877 | Dyslipidemias|Cardiovascular Diseases|Hypertriglyceridemia | Drug: fenofibrate | Abbott|Rundo International Pharmaceutical Research & Development Co.,Ltd. | Phase 4 | 2011-10-01 | 2015-02-25 |
NCT00362934 | Hyperlipidemia | Drug: fenofibrate / simvastatin|Drug: Atorvastatin | Solvay Pharmaceuticals | Phase 3 | 2006-10-01 | 2009-07-07 |
NCT00934219 | Hypertriglyceridemia | Drug: Omega-3-Acid Ethyl Esters | Jewish Hospital, Cincinnati, Ohio|GlaxoSmithKline | Phase 4 | 2009-07-01 | 2009-07-07 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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