Home > PPAR & PPAR & > Clofibric Acid

Clofibric Acid

4-氯苯氧异丁酸,氯贝酸

Clofibric Acid是PPARα激动剂,是一种降血脂剂。

目录号
EY1112
EY1112
纯度
99.57%
99.57%
规格
500 mg
1 g
原价
180
350
售价
180
350
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Clofibric acid is a PPARα agonist and hypolipidemic agent.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Muerhoff AS, et al. J Biol Chem, 1992, 267(27), 19051-19053.

    分子式
    C10H11ClO3
    分子量
    214.65
    CAS号
    882-09-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    41 mg/mL
    Water
    <1 mg/mL
    Ethanol
    41 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01527318 Neutral Lipid Storage Disease Drug: Fibrate treatment Maastricht University Medical Center Phase 4 2011-08-01 2013-05-13
    NCT00243672 Atherosclerosis Drug: Atorvastatin|Drug: Gemfibrozil University Hospital Muenster Phase 4 2005-10-01 2007-11-16
    NCT00491400 Diabetes Mellitus|Metabolic Syndrome Drug: Fenofibrate|Drug: Atorvastatin Boston University 2005-09-01 2012-09-24
    NCT00156169 Low HDL Cholesterol Drug: Dunaliella Sheba Medical Center Phase 3 2001-05-01 2009-08-10
    NCT02530827 HIV/AIDS|HIV Lipodystrophy Syndrome Drug: use of lipid-lowering drugs. University of Sao Paulo General Hospital|Fundao de Amparo Pesquisa do Estado de So Paulo 2013-03-01 2015-08-20
    NCT00728910 Dyslipidemia Drug: Atorvastatin|Drug: ABT335|Drug: ER Niacin University of Pennsylvania|Abbott Phase 2 2008-06-01 2016-01-28
    NCT01385020 Healthy Subjects Drug: Gemfibrozil & red yeast rice (LipoCol) National Taiwan University Hospital|National Science Council, Taiwan Phase 4 2011-07-01 2011-10-13
    NCT01654731 PBC Drug: Bezafibrate|Drug: placebo Assistance Publique - Hpitaux de Paris Phase 3 2012-10-01 2017-02-20
    NCT00458055 Coronary Arteriosclerosis|Hypoalphalipoproteinemias|Genetic Diseases, Inborn Drug: Atorvastatin; Fenofibrate; Niacin McGill University Health Center 2006-11-01 2008-06-02
    NCT01674712 Dyslipidemia Drug: Fixed Combination of Fenofibrate/simvastatin 145/20 mg|Drug: Simvastatin 20 mg|Drug: Fenofibrate 145 mg|Drug: Fixed Combination of Fenofibrate/simvastatin 145/40 mg|Drug: Simvastatin 40 mg Abbott Phase 3 2012-06-01 2014-11-24
    NCT00965315 Diabetes|CVD Drug: Rosuvastatin,SFC fenofibrate National Taiwan University Hospital
    2012-12-20
    NCT01477944 Hypercholesteremia AstraZeneca 2012-02-01 2012-02-20
    NCT01148004 HIV|Fenofibrate|Protease Inhibitors|Hypertriglyceridemia|Glucuronosyltransferase Drug: Fenofibrate|Drug: Ritonavir|Drug: Lopinavir/Ritonavir National Institutes of Health Clinical Center (CC) Phase 1 2010-05-13 2017-02-01
    NCT00037401 Atherosclerosis|Cardiovascular Diseases|Hypercholesterolemia|Heart Diseases National Heart, Lung, and Blood Institute (NHLBI) 2001-09-01 2016-02-17
    NCT01602913 Depression, Postpartum Drug: Pravastatin alone|Drug: Paroxetine alone|Drug: Pravastatin and paroxetine combined GlaxoSmithKline 2011-12-01 2014-06-30
    NCT01025492 Dyslipidemia Drug: Trilipix|Drug: placebo University of Utah|Abbott Phase 4 2009-11-01 2016-07-19
    NCT00362206 Hyperlipidemia Drug: Fenofibrate/Simvastatin|Drug: Fenofibrate/Simvastatin|Drug: Pravastatin Solvay Pharmaceuticals Phase 3 2006-09-01 2009-07-07
    NCT00352183 Cardiovascular Diseases Drug: Fenofibrate/Simvastatin|Drug: Simvastatin Solvay Pharmaceuticals Phase 3 2006-01-01 2009-07-07
    NCT00349375 Hyperlipidemia Drug: Fenofibrate/Simvastatin|Drug: Fenofibrate/Simvastatin|Drug: Simvastatin Solvay Pharmaceuticals Phase 3 2005-11-01 2009-07-07
    NCT01462877 Dyslipidemias|Cardiovascular Diseases|Hypertriglyceridemia Drug: fenofibrate Abbott|Rundo International Pharmaceutical Research & Development Co.,Ltd. Phase 4 2011-10-01 2015-02-25
    NCT00362934 Hyperlipidemia Drug: fenofibrate / simvastatin|Drug: Atorvastatin Solvay Pharmaceuticals Phase 3 2006-10-01 2009-07-07
    NCT00934219 Hypertriglyceridemia Drug: Omega-3-Acid Ethyl Esters Jewish Hospital, Cincinnati, Ohio|GlaxoSmithKline Phase 4 2009-07-01 2009-07-07

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :